Effects of organophosphates on glucose and urea net production in isolated perfused rat liver

0.426 mg/kg Paraoxon was applicated to female Sprague-Dawley rats. 4, 10 and 24 h after poisoning, cholesterol, glyceride and phospholipid content was measured in liver plasma membranes and mitochondria. After 4 h, cholesterol content of plasma membranes was significantly lower. Phospholipid content of plasma membranes was significantly higher than control values at all times of investigation, contents of neutral lipids and glycerides were also higher, but not significantly. In mitochondria, no significant difference of cholesterol content could be detected. Glyceride content was lower after 4 and 10 h, but phospholipid content higher at all experimental times. Differences found in cholesterol and phospholipid content of plasma membranes are discussed also in view of higher serum GOT, GPT and CPK activities known from other investigations. The differences in cholesterol and phospholipid content, their degree and their timing, which agrees with the timing of enzyme leakage, suggest that lipid composition of the plasma membrane may be one of the parameters which determine membrane permeability after organophosphate poisoning.

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Glucose metabolism in hepatopancreas and gill of Lamellidens marginallis during methyl parathion toxicity

Moorthy

Reddy

Swami

et al. 1985

Pesticide Biochemistry and Physiology

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Effects of organophosphates on glucose and urea net production in isolated perfused rat liver

Cited by 5 publications

References 21 publications

Untersuchungen zur Lebertoxicität von Nitrostigmin (Parathion, E 605) an der perfundierten Rattenleber

Untersuchungen zur Lebertoxicität von Nitrostigmin (Parathion, E 605) an der perfundierten Rattenleber

Lipide der Plasmamembranen und der Mitochondrien aus Rattenleber nach Paraoxon-Intoxikation

Glucose metabolism in hepatopancreas and gill of Lamellidens marginallis during methyl parathion toxicity

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