Effects of orbital prefrontal cortex dopamine depletion on inter-temporal choice: a quantitative analysis

Kheramin, S.; Body, S.; Ho, M.-Y.; Velázquez-Martínez, David N.; Bradshaw, C. M.; Szabadi, E.; Deakin, Bill; Anderson, Ian M.

doi:10.1007/s00213-004-1813-y

Cited by 116 publications

(104 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rats in both the AcbC-and shamlesioned groups shifted their preference from the larger to the smaller reinforcer as the delay to the larger of the two reinforcers (d B ) was progressively increased during a session. This is consistent with previous studies that have used this schedule Ryan 1996, 1999;Cardinal et al 2000Cardinal et al , 2001Kheramin et al 2002Kheramin et al , 2003Kheramin et al , 2004Winstanley et al 2004Winstanley et al , 2005.…”

Section: Discussionsupporting

confidence: 92%

“…This suggests that the ideal preference function should be a step function, %B falling precipitously from near 100% to near 0% around the point at which V A =V B . However, the preference functions in Figure 1 show a gradual reduction of preference as a function of d B , a result that appears to be common to all previous studies employing Evenden and Ryan's (1996) protocol Ryan 1996, 1999;Cardinal et al 2000Cardinal et al , 2001Kheramin et al 2002Kheramin et al , 2003Kheramin et al , 2004Winstanley et al 2004Winstanley et al , 2005). This is not simply an artefact of averaging step functions derived from several individuals, because individual rats also show progesssive declines in preference as a function of d B (see below).…”

Section: Discussionsupporting

confidence: 76%

“…As in previous experiments (Kheramin et al 2002(Kheramin et al , 2003(Kheramin et al , 2004 (Ho et al 1999), allows formal separation of the parameters that represent the rate of delay discounting and sensitivity to reinforcer magnitude (see below).…”

Section: Discussionmentioning

confidence: 99%

“…Cresyl violet staining-The procedure was the same as that described by Kheramin et al (2002). Alternate sections were mounted on gelatine-coated slides, and dried in formaldehyde vapour for 24 hours.…”

Section: Histologymentioning

confidence: 99%

See 3 more Smart Citations

Effects of quinolinic acid-induced lesions of the nucleus accumbens core on inter-temporal choice: a quantitative analysis

et al. 2007

Self Cite

View full text Add to dashboard Cite

Rationale-There is evidence that lesions of the nucleus accumbens core (AcbC) promote preference for smaller earlier reinforcers over larger delayed reinforcers in inter-temporal choice paradigms. It is not known whether this reflects an effect of the lesion on the rate of delay discounting, on sensitivity to reinforcer magnitude, or both.Aim-We examined the effect of AcbC lesions on inter-temporal choice using a quantitative method that allows effects on delay discounting to be distinguished from effects on sensitivity to reinforcer size. B(50) increased linearly with d A (r 2 >0.95 in each group). The intercept of the indifference function was lower in the lesioned than the sham-lesioned group; slope did not differ between groups. The lesioned rats had extensive neuronal loss in the AcbC. Results-d Conclusions-The results confirm that lesions of the AcbC promote preference for smaller, earlier reinforcers and suggest that this reflects an effect of the lesion on the rate of delay discounting.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Histologymentioning

confidence: 99%

See 2 more Smart Citations

Effects of quinolinic acid-induced lesions of the nucleus accumbens core on inter-temporal choice: a quantitative analysis

et al. 2007

Self Cite

View full text Add to dashboard Cite

show abstract

“…The ventral tegmental area (VTA) sends dopaminergic projections to the OFC (Berger et al, 1991;Dunnett and Robbins, 1992;Frankle et al, 2006;Geisler et al, 2007;Sesack and Grace, 2010). Furthermore, dopaminergic neurotransmission in the frontal cortices critically regulates higher-order cognitive function, including reward-related processing by the OFC that likely facilitates cocaine-seeking behavior (Cetin et al, 2004;Dalley et al, 2004;Kheramin et al, 2004;Ragozzino et al, 1999;Ward et al, 2009;Winter et al, 2009). Systemic dopamine D1-like receptor antagonism impairs drug context-induced cocaine-seeking behavior (Crombag et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Contribution of a Mesocorticolimbic Subcircuit to Drug Context-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

Lasseter

Xie

Arguello

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

Cocaine-seeking behavior triggered by drug-paired environmental context exposure is dependent on orbitofrontal cortex (OFC)-basolateral amygdala (BLA) interactions. Here, we present evidence supporting the hypothesis that dopaminergic input from the ventral tegmental area (VTA) to the OFC critically regulates these interactions. In experiment 1, we employed site-specific pharmacological manipulations to show that dopamine D1-like receptor stimulation in the OFC is required for drug context-induced reinstatement of cocaine-seeking behavior following extinction training in an alternate context. Intra-OFC pretreatment with the dopamine D1-like receptor antagonist, SCH23390, dose-dependently attenuated cocaine-seeking behavior in an anatomically selective manner, without altering motor performance. Furthermore, the effects of SCH23390 could be surmounted by co-administration of a sub-threshold dose of the D1-like receptor agonist, SKF81297. In experiment 2, we examined effects of D1-like receptor antagonism in the OFC on OFC-BLA interactions using a functional disconnection manipulation. Unilateral SCH23390 administration into the OFC plus GABA agonist-induced neural inactivation of the contralateral or ipsilateral BLA disrupted drug context-induced cocaine-seeking behavior relative to vehicle, while independent unilateral manipulations of these brain regions were without effect. Finally, in experiment 3, we used fluorescent retrograde tracers to demonstrate that the VTA, but not the substantia nigra, sends dense intra-and interhemispheric projections to the OFC, which in turn has reciprocal bi-hemispheric connections with the BLA. These findings support that dopaminergic input from the VTA, via dopamine D1-like receptor stimulation in the OFC, is required for OFC-BLA functional interactions. Thus, a VTA-OFC-BLA neural circuit promotes drug context-induced motivated behavior.

show abstract

Delay Discounting and Impulsive Choice in the Rat

Mar

Robbins

2007

CP Neuroscience

View full text Add to dashboard Cite

Delay discounting refers to the degree to which immediate outcomes exhibit more influence over behavior than outcomes which are delayed. Impulsive choice, in the context of delay discounting, is generally considered as an increased preference for immediate over delayed outcomes, even where the delayed outcomes are more advantageous. In the past decade, there has been increasing use of delay-discounting paradigms to elucidate the physiological, pharmacological, and behavioral aspects of the putative neural circuitry underlying impulsive choice. This unit describes the assessment of impulsive choice in the rat using a delay-discounting procedure involving an operant response choice between a small reinforcer delivered immediately and a larger reinforcer delivered after a delay, which is progressively increased within a session. Variations of some of the main task parameters are also discussed, as well as their significance and interpretation.

show abstract

Effects of orbital prefrontal cortex dopamine depletion on inter-temporal choice: a quantitative analysis

Abstract: The results indicate that dopaminergic afferents to the OPFC contribute to the regulation of inter-temporal choice behaviour due to their role in determining organisms' sensitivity both to reinforcer size and to delay of reinforcement.

Cited by 116 publications

References 47 publications

Effects of quinolinic acid-induced lesions of the nucleus accumbens core on inter-temporal choice: a quantitative analysis

Effects of quinolinic acid-induced lesions of the nucleus accumbens core on inter-temporal choice: a quantitative analysis

Contribution of a Mesocorticolimbic Subcircuit to Drug Context-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

Delay Discounting and Impulsive Choice in the Rat

Contact Info

Product

Resources

About