Effects of oral pretreatment with metoprolol on left ventricular wall motion, infarct size, hemodynamics, and regional myocardial blood flow in anesthetized dogs during thrombotic coronary artery occlusion and reperfusion

Żmudka, Krzysztof; Dubiel, J; Vanhaecke, Johan; Flameng, Willem; Geest, H De

doi:10.1007/bf00877926

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…Although TTC staining to discriminate between VIT and NIT may require a certain period of reperfusion [37], it does allow for sensitive and specific determination of infarct size [38]. We and other authors have previously shown the validity of TTC staining in this and other models [18,39,40]. Isoflurane is known to have a protective effect in terms of preconditioning [25].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Multimeric Tyrosine-O-Sulfate as a Cytoprotectant in an in vivo Model of Acute Myocardial Infarction in Pigs

Banz

Hess²,

Meier³

et al. 2012

Cardiology

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Objectives: Intracoronary administration of glycosaminoglycan analogs, including the complement inhibitor dextran sulfate, attenuates myocardial ischemia/reperfusion injury (I/R injury). However, dextran sulfate has a distinct anticoagulatory effect, possibly limiting its use in specific situations in vivo. We therefore developed multimeric tyrosine sulfate (sTyr-PAA), a novel, minimally anticoagulatory, fully synthetic non-carbohydrate-containing polyacrylamide conjugate, for in vivo testing in an acute closed-chest porcine model of acute myocardial infarction. Methods: Following balloon occlusion of the left anterior descending artery just after the first diagonal branch (60-minute ischemia), sTyr-PAA (approx. 10 mg/kg bodyweight, fraction with strongest complement-inhibitory and minimal anticoagulatory properties, n = 11) or phosphate-buffered saline (controls, n = 9) was administered intracoronarily into ischemic myocardium prior to 120 min of reperfusion. Results: sTyr-PAA significantly reduced infarct size (from 61.0 ± 12.0% of the ischemic area at risk to 39.4 ± 17.0%), plasma creatine kinase, local complement deposition and tissue factor upregulation, without affecting systemic coagulation. Protection was associated with significantly reduced myocardial neutrophil extravasation and translated into a significant improvement of ejection fraction and left ventricular enddiastolic pressure. Conclusions: sTyr-PAA protected significantly against myocardial I/R injury without substantially affecting systemic coagulation. Local intravascular sTyr-PAA administration may prove advantageous in situations where bleeding complications are likely or are to be avoided at all costs.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Multimeric Tyrosine-O-Sulfate as a Cytoprotectant in an in vivo Model of Acute Myocardial Infarction in Pigs

Banz

Hess²,

Meier³

et al. 2012

Cardiology

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Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction

Heusch

Skyschally

Gres

et al. 2008

European Heart Journal

126

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Evaluation antianginös wirkender Kanal- und Rezeptorblocker in einem koronaren Arteriogenesemodell der Ratte

Güc¹

2016

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Effects of oral pretreatment with metoprolol on left ventricular wall motion, infarct size, hemodynamics, and regional myocardial blood flow in anesthetized dogs during thrombotic coronary artery occlusion and reperfusion

Abstract: Oral pretreatment with metoprolol limited infarct size and improved regional left ventricular function, probably due to its negative chronotropic and inotropic effects, and also due to an enhancement of collateral flow fr

Cited by 3 publications

References 33 publications

Evaluation of Multimeric Tyrosine-O-Sulfate as a Cytoprotectant in an in vivo Model of Acute Myocardial Infarction in Pigs

Evaluation of Multimeric Tyrosine-O-Sulfate as a Cytoprotectant in an in vivo Model of Acute Myocardial Infarction in Pigs

Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction

Evaluation antianginös wirkender Kanal- und Rezeptorblocker in einem koronaren Arteriogenesemodell der Ratte

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