Effects of Oral Magnesium Therapy on Exercise Tolerance, Exercise-Induced Chest Pain, and Quality of Life in Patients With Coronary Artery Disease

Shechter, Michael; Merz, C. Noel Bairey; Stuehlinger, Hermann Georg; Slaný, J; Pachinger, Otmar; Rabinowitz, Babeth

doi:10.1016/s0002-9149(02)03297-6

Cited by 34 publications

(22 citation statements)

References 17 publications

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“…However, controversial clinical data exist on the potential benefits of oral Mg substitution. Although Mg substitution was found to improve endothelial function and exercise tolerance in patients with stable coronary artery disease as well as after acute myocardial infarction, [32][33][34][35] others found no significant clinical improvement in patients with Mg therapy. 36,37 Our data support the view that it at least may be worth considering Mg substitution for patients with low Mg serum levels who are at high risk for neurological events.…”

Section: Amighi Et Al Magnesium and Neurological Events 25mentioning

confidence: 99%

Low Serum Magnesium Predicts Neurological Events in Patients With Advanced Atherosclerosis

Amighi

Sabeti

Schlager

et al. 2004

Stroke

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Background and Purpose-Magnesium (Mg) deficiency is thought to be a risk factor for cerebrovascular atherosclerosis and complications. We investigated the prognostic impact of Mg serum levels with respect to the occurrence of neurological events in patients with advanced atherosclerosis. Methods-We prospectively studied 323 patients with symptomatic peripheral artery disease and intermittent claudication (197 men; median age, 68 years). Serum Mg was determined, and patients were followed for a median of 20 months (interquartile range, 12 to 25 months) for the occurrence of neurological events, defined as ischemic stroke and/or carotid revascularization (carotid endarterectomy or carotid stenting). Multivariate Cox proportional hazards analysis was applied to assess the association of serum Mg (in tertiles) and neurological events. Results-Neurological events occurred in 35 patients (11%) (15 patients with stroke, 13 with carotid revascularization, and 7 with stroke and subsequent revascularization

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Section: Amighi Et Al Magnesium and Neurological Events 25mentioning

confidence: 99%

Low Serum Magnesium Predicts Neurological Events in Patients With Advanced Atherosclerosis

Amighi

Sabeti

Schlager

et al. 2004

Stroke

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“…Oral magnesium therapy (365 mg twice daily for 6 months) in 187 patients with CAD demonstrated a 14% improvement in exercise duration combined with a decrease in exercise-induced chest pain compared to no change in the placebo group (169). In patients with congestive heart failure (CHF), a population at high risk for magnesium deficiency, oral magnesium replacement decreases the frequency of ventricular arrhythmias (170).…”

Section: Folic Acid Vitamin B 6 and Vitamin B 12mentioning

confidence: 99%

Integrating Complementary Medicine Into Cardiovascular Medicine

Vogel¹,

Bolling²,

Costello³

et al. 2005

Journal of the American College of Cardiology

118

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“…Mg ϩϩ (EXAtest) correlating with clinical data, has demonstrated that Mg ϩϩ supplementation improves endothelial function in patients with coronary artery disease (CAD). However, the impact on clinical outcomes, such as exercise-induced chest pain, exercise tolerance, and quality of life, was not established a study in 2003 [17].…”

Section: Exercise Tolerance Chest Pain and Quality Of Lifementioning

confidence: 99%

“…Mg ϩϩ concentration, exercise tolerance, exercise-induced chest pain, and quality of life, suggesting a potential mechanism whereby Mg ϩϩ therapy and use of the i.c. EXAtest could beneficially alter outcomes in patients with CAD [17] (Figs. 9, 10).…”

Section: Exercise Tolerance Chest Pain and Quality Of Lifementioning

confidence: 99%

Development of Cellular Magnesium Nano-Analysis in Treatment of Clinical Magnesium Deficiency

Silver

2004

Journal of the American College of Nutrition

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A novel technique, using energy dispersive X-ray microanalysis (EXAtm), for noninvasive intracellular (i.c.) measurement of magnesium [Mg2+]i has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Since only 1% of total body Mg2+ is found in the intravascular space, serum levels of Mg2+ give little information about a patient's overall Mg2+ status with respect to this essential mineral. Using the EXAtm analysis it has shown been determined that Mg2+ levels are significantly reduced in many physiological states which may lead to serious pathological conditions [15]. Description of the methodology and examples of data as well as potential applications will focus on intracellular (i.c.) [Mg2+]i determinations obtained in cells from subjects with cardiovascular disease (CVD) syndromes related to Mg2+ deficiency. Examples of the application of EXAtm evaluation include examination of intracellular magnesium and other minerals in a wide spectrum of conditions which include cardiovascular conditions, arrhythmias, heart failure, myocardial infarction, and bypass surgery. Standardization of control values were performed at NASA.

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Effects of Oral Magnesium Therapy on Exercise Tolerance, Exercise-Induced Chest Pain, and Quality of Life in Patients With Coronary Artery Disease

Cited by 34 publications

References 17 publications

Low Serum Magnesium Predicts Neurological Events in Patients With Advanced Atherosclerosis

Low Serum Magnesium Predicts Neurological Events in Patients With Advanced Atherosclerosis

Integrating Complementary Medicine Into Cardiovascular Medicine

Development of Cellular Magnesium Nano-Analysis in Treatment of Clinical Magnesium Deficiency

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