Effects of oral d-aspartate on sperm quality in B6N mice

Raspa, Marcello; Mahabir, Esther; Paoletti, Renata; Protti, Michele; Mercolini, Laura; Schiller, Petra; Scavizzi, Ferdinando

doi:10.1016/j.theriogenology.2018.07.040

Cited by 10 publications

(24 citation statements)

References 46 publications

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“…In Table 3, we have reported the effects of chronic administration of D-Asp (long-term experiments) on mice and rats. Sexually immature (seven-week-old) male mice C57BL/6NT (B6N) were treated with a dose of 20 mM D-Asp in drinking water [48]. Parameters such as efficiency of in vitro fertilization (IVF), the quality of frozen-thawed sperm, as well as luteinizing hormone (LH), epitestosterone, and T levels were investigated.…”

Section: Laboratory Animalsmentioning

confidence: 99%

D-Aspartic Acid in Vertebrate Reproduction: Animal Models and Experimental Designs

et al. 2019

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This article reviews the animal models and experimental designs that have been used during the past twenty years to demonstrate the prominent role played by D-aspartate (D-Asp) in the reproduction of vertebrates, from amphibians to humans. We have tabulated the findings of in vivo and in vitro experiments that demonstrate the effects of D-Asp uptake on hormone production and gametogenesis in vertebrate animal models. The contribution of each animal model to the existing knowledge on the role of D-Asp in reproductive processes has been discussed. A critical analysis of experimental designs has also been carried out. Experiments performed on wild animal species suggest a role of D-Asp in the mechanisms that regulate the reproductive cycle. Several in vivo and in vitro studies carried out on mouse and rat models have facilitated an understanding of the molecular pathways activated by D-Asp in both steroidogenesis and spermatogenesis, with particular emphasis on testosterone biosynthesis. Some attempts using D-Asp for the improvement of reproductive activity in animals of commercial interest have yielded mixed results. The increased transcriptome activity of enzymes and receptors involved in the reproductive activity in D-Asp-treated broiler roosters revealed further details on the mechanism of action of D-Asp on the reproductive processes. The close relationship between D-Asp and reproductive activity has emerged, particularly in relation to its effects exerted on semen quality, proposing therapeutic applications of this amino acid in andrology and in medically-assisted procreation techniques.

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Section: Laboratory Animalsmentioning

confidence: 99%

D-Aspartic Acid in Vertebrate Reproduction: Animal Models and Experimental Designs

et al. 2019

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“…An increase in serum androstenedione and progesterone levels has also been detected [93,103,117,123,124]. Similarly, treatment with D-Asp in mice induced a significant increase in serum and testis LH, testosterone, and epitestosterone [18,19]. The increase in sex steroid hormone levels results from the effect of this D-amino acid on the transcription of the acute steroidogenic regulatory protein (StAR), which is a primary regulatory protein for the biosynthesis of testosterone in the testis as well as of steroidogenic enzymes (Figure 1) [117,124].…”

Section: D-asp Administration On the Hypothalamus-pituitary-testis Axismentioning

confidence: 72%

“…Experimental studies performed in various animal models have shown that D-Asp acts at all levels of the hypothalamic-pituitary-testis axis, which suggests that this D-amino acid plays a role also in vertebrate reproductive processes [16][17][18][19]91]. D-Asp has been found in substantial amounts in the mammalian pituitary gland [92,100,110,119,120].…”

Section: D-asp Administration On the Hypothalamus-pituitary-testis Axismentioning

confidence: 99%

“…Finally, experiments on isolated mouse spermatozoa showed that D-Asp improved total and progressive sperm motility [18,19]. Furthermore, treatment with a commercial mixture of Coenzyme Q10, zinc, and D-Asp (CZA) exerts a protective effect on bovine spermatozoa, since it counteracts the loss of motility by acting on the mitochondrial membrane potential (MMP) and DNA fragmentation [17,139].…”

Section: D-asp Administration On the Hypothalamus-pituitary-testis Axismentioning

confidence: 99%

“…Furthermore, D-Asp regulates the synthesis and release of testosterone by promoting the release of gonadotropin-releasing hormone (GnRH) in the hypothalamus and luteinizing hormone (LH) in the pituitary. D-Asp can promote animal reproduction also by directly activating spermatogonia proliferation and improving sperm quality [18,19].…”

Section: Introductionmentioning

confidence: 99%

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New Evidence on the Role of D-Aspartate Metabolism in Regulating Brain and Endocrine System Physiology: From Preclinical Observations to Clinical Applications

Usiello

Fiore

Rosa

et al. 2020

IJMS

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The endogenous amino acids serine and aspartate occur at high concentrations in free D-form in mammalian organs, including the central nervous system and endocrine glands. D-serine (D-Ser) is largely localized in the forebrain structures throughout pre and postnatal life. Pharmacologically, D-Ser plays a functional role by acting as an endogenous coagonist at N-methyl-D-aspartate receptors (NMDARs). Less is known about the role of free D-aspartate (D-Asp) in mammals. Notably, D-Asp has a specific temporal pattern of occurrence. In fact, free D-Asp is abundant during prenatal life and decreases greatly after birth in concomitance with the postnatal onset of D-Asp oxidase expression, which is the only enzyme known to control endogenous levels of this molecule. Conversely, in the endocrine system, D-Asp concentrations enhance after birth during its functional development, thereby suggesting an involvement of the amino acid in the regulation of hormone biosynthesis. The substantial binding affinity for the NMDAR glutamate site has led us to investigate the in vivo implications of D-Asp on NMDAR-mediated responses. Herein we review the physiological function of free D-Asp and of its metabolizing enzyme in regulating the functions of the brain and of the neuroendocrine system based on recent genetic and pharmacological human and animal studies.

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2020

Biological Chirality

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Effects of oral d-aspartate on sperm quality in B6N mice

Cited by 10 publications

References 46 publications

D-Aspartic Acid in Vertebrate Reproduction: Animal Models and Experimental Designs

D-Aspartic Acid in Vertebrate Reproduction: Animal Models and Experimental Designs

New Evidence on the Role of D-Aspartate Metabolism in Regulating Brain and Endocrine System Physiology: From Preclinical Observations to Clinical Applications

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