Effects of Oral ATP Supplementation on Anaerobic Power and Muscular Strength

Jordan, Alexander N.; Jurča, Radim; Abraham, Edward; Salikhova, Anna Y.; Mann, Julia; Morss, Gina M.; Church, Timothy S.; Lucía, Alejandro; Earnest, Conrad P.

doi:10.1249/01.mss.0000128198.97260.8b

Cited by 34 publications

(69 citation statements)

References 29 publications

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“…Adenosine-5=-triphosphate (ATP) and ATP metabolites are involved in a myriad of biological processes including cardiac function, neurotransmission, blood flow, and muscle contraction (Agteresch et al 1999;Kushmerick and Conley 2002), and it is strongly suggested that increased ATP levels correlate with improved health and performance (Jordan et al 2004;Herda et al 2008;Swamy et al 2011). Direct supplementation with exogenous ATP has produced mixed results in terms of increasing ATP when measured in whole blood (Jordan et al 2004;Arts et al 2012;Burnstock et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men

Joy

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Vogel

et al. 2015

Appl. Physiol. Nutr. Metab.

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Adenosine-5=-triphosphate (ATP) is primarily known as a cellular source of energy. Increased ATP levels may have the potential to enhance body composition. A novel, proprietary blend of ancient peat and apple extracts has been reported to increase ATP levels, potentially by enhancing mitochondrial ATP production. Therefore, the purpose of this investigation was to determine the supplement's effects on body composition when consumed during 12 weeks of resistance training. Twenty-five healthy, resistance-trained, male subjects (age, 27.7 ± 4.8 years; height, 176.0 ± 6.5 cm; body mass, 83.2 ± 12.1 kg) completed this study. Subjects supplemented once daily with either 1 serving (150 mg) of a proprietary blend of ancient peat and apple extracts (TRT) or placebo (PLA). Supervised resistance training consisted of 8 weeks of daily undulating periodized training followed by a 2-week overreach and a 2-week taper phase. Body composition was assessed using dual-energy X-ray absorptiometry and ultrasound at weeks 0, 4, 8, 10, and 12. Vital signs and blood markers were assessed at weeks 0, 8, and 12. Significant group × time (p < 0.05) interactions were present for ultrasound-determined cross-sectional area, which increased in TRT (+0.91 cm 2 ) versus PLA (-0.08 cm 2 ), as well as muscle thickness (TRT: +0.46; PLA: +0.04 cm). A significant group × time (p < 0.05) interaction existed for creatinine (TRT: +0.06; PLA: +0.15 mg/dL), triglycerides (TRT: +24.1; PLA: -20.2 mg/dL), and very-low-density lipoprotein (TRT: +4.9; PLA: -3.9 mg/dL), which remained within clinical ranges. Supplementation with a proprietary blend of ancient peat and apple extracts may enhance resistance training-induced skeletal muscle hypertrophy without affecting fat mass or blood chemistry in healthy males.Key words: ElevATP, strength training, weight lifting, muscle mass, fat mass, blood chemistry, safety, periodization, sports nutrition, sport. On observe une interaction groupe-temps significative (p < 0,05) de la surface de section transversale mesurée par ultrasonographie, laquelle augmente dans le groupe TRT (+0,91 cm 2 ) vs PLA (-0,08 cm 2 ); il en est de même de l'épaisseur du muscle (TRT : +0,46 cm; PLA: +0,04 cm). On observe aussi une interaction groupe-temps significative (p < 0,05) en ce qui concerne la créatinine (TRT : +0,06; PLA : +0,15 mg/dL), les triglycérides (TRT : +24,1; PLA : -20,2 mg/dL) et les VLDL (TRT : +4,9; PLA : -3,9 mg/dL) dont les valeurs demeurent dans la normale clinique. La supplémentation au moyen d'un mélange exclusif d'extraits de tourbe ancienne et de pomme peut améliorer l'hypertrophie du muscle squelettique causée par un entraînement contre résistance, et ce, sans modifier la masse adipeuse et la chimie sanguine d'hommes en bonne santé. [Traduit par la Rédaction]

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Section: Introductionmentioning

confidence: 99%

“…Direct supplementation with exogenous ATP has produced mixed results in terms of increasing ATP when measured in whole blood (Jordan et al 2004;Arts et al 2012;Burnstock et al 2012). Therefore, an indirect approach for increasing endogenous ATP levels may be desirable.…”

Section: Introductionmentioning

confidence: 99%

Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men

Joy

Falcone

Vogel

et al. 2015

Appl. Physiol. Nutr. Metab.

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“…The first studies with direct oral ATP found low to nonsignificant performance improvements likely due to dose, amount, and timing of ingestion relative to exercise. However, Jordan et al observed increases in within-group 1 repetition maximum (nearly 7%) and lifting volume (18.5%) with 225 mg of ATP in only 14 days of supplementation with untrained individuals who did nothing in the interim [10]. Recently, at a higher dose (400 mg), Rathmacher et al observed improvement in low peak torque in set 2 with 400 mg of ATP compared to the placebo in only 15 days [11].…”

Section: Effects Of Atp Supplementation On Peak Power and Muscle Excimentioning

confidence: 99%

“…Low-dose ATP supplementation (150 or 225 mg enteric-coated ATP per day) for 15 days did not alter bench press strength and endurance or peak or average Wingate power. However, ATP supplementation resulted in increased total bench press lifting volume (i.e., setsrepetitionsload) as well as within-group set 1 repetitions to failure [10]. Higher dose (400 mg per day for 15 days) ATP supplementation in form of the uncoated disodium salt increased minimum peak torque for the final 2 sets of a dynamometer test [11] and postexercise blood flow (400 mg ATP as disodium salt per day for 12 weeks) [12].…”

Section: Introductionmentioning

confidence: 99%

Oral Adenosine-5′-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout

Purpura¹,

Rathmacher

Sharp

et al. 2017

Journal of the American College of Nutrition

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Objective: Oral adenosine-5 0 -triphosphate (ATP) administration has failed to increase plasma ATP levels; however, chronic supplementation with ATP has shown to increase power, strength, lean body mass, and blood flow in trained athletes. The purpose of this study was to investigate the effects of ATP supplementation on postexercise ATP levels and on muscle activation and excitability and power following a repeated sprint bout. Methods: In a double-blind, placebo-controlled, randomized design, 42 healthy male individuals were given either 400 mg of ATP as disodium salt or placebo for 2 weeks prior to an exercise bout. During the exercise bout, muscle activation and excitability (ME, ratio of power output to muscle activation) and Wingate test peak power were measured during all sprints. ATP and metabolites were measured at baseline, after supplementation, and immediately following exercise. Results: Oral ATP supplementation prevented a drop in ATP, adenosine-5 0 -diphosphate (ADP), and adenosine-5 0 -monophosphate (AMP) levels postexercise (p < 0.05). No group by time interaction was observed for muscle activation. Following the supplementation period, muscle excitability significantly decreased in later bouts 8, 9, and 10 in the placebo group (¡30.5, ¡28.3, and ¡27.9%, respectively; p < 0.02), whereas ATP supplementation prevented the decline in later bouts. ATP significantly increased Wingate peak power in later bouts compared to baseline (bout 8: C18.3%, bout 10: C16.3%). Conclusions: Oral ATP administration prevents exercise-induced declines in ATP and its metabolite and enhances peak power and muscular excitability, which may be beneficial for sports requiring repeated high-intensity sprinting bouts.

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“…ATP released from the cell represents less than 1% of the intracellular ATP pool, which indicates that extracellular ATP signaling can be achieved without compromising cellular metabolism or any other essential intracellular reactions. ATP released by cells is typically in response to various stimuli, such as mechanical pressure, or after treatment with agonists, such as serotonin and acetylcholine [5]. Extracellular ATP is a requirement for several physiological processes, such as neurotransmission, clot formation, cell recognition and expansion and immune responses [6].…”

Section: Introductionmentioning

confidence: 99%

Acute Effect of MCRC on Selected Blood Parameters - A Placebo-controlled Acute Clinical Study

Reyes-Izquierdo¹,

Nemzer²,

Zhou³

et al. 2012

Am. J. Biomed. Sci.

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Acute clinical testing was performed on healthy human subjects to verify whether a single 150mg dose of a proprietary formula marketed under the trade name "Mitochroma TM " (MCRC) can actually increase blood levels of ATP. Sera and blood were collected immediately prior to treatment and at times 30, 60, and 90 minutes after treatment to measure amounts of blood ATP, lactate, ROS, and pO 2 . Additionally, whole blood was collected at 270 minutes after treatment to measure expression of selected cytokines and chemokines. In comparison to the placebo group, samples collected from subjects treated with MCRC showed increased levels of total blood ATP by 12.5% on average and reduced levels of lactate up to 13%. Blood levels of ROS and pO 2 were found unchanged under these experimental conditions. Analyses of blood collected at 270 minutes showed reduced levels of MCP-1 by up to 21%, and increased levels of Interferonalpha up to 16%. In summary, collected data shows that treatment with a single dose of MCRC resulted in an acute increase in blood levels of total blood ATP. These results justify further clinical studies on MCRC in order to determine the effects on a more narrowly selected subject population with reduced blood levels of ATP and increased blood levels of MCP-1.

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Effects of Oral ATP Supplementation on Anaerobic Power and Muscular Strength

Abstract: We conclude that enterically coated oral ATP supplementation may provide small ergogenic effects on muscular strength under some treatment conditions.

Cited by 34 publications

References 29 publications

Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men

Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men

Oral Adenosine-5′-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout

Acute Effect of MCRC on Selected Blood Parameters - A Placebo-controlled Acute Clinical Study

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