Effects of Oral Alcohol on Superior Mesenteric Artery Blood Flow in Normal Man, Horizontal and Tilted

Abstract

1. The cardiovascular effects of oral alcohol (0.5 g/kg body weight diluted to 300 ml in sugar-free orange juice) were compared with those of placebo in 10 normal subjects. Measurements were made while the subjects were supine and horizontal for 45 min and after 10 min of 45 degrees head-up tilt. 2. After alcohol, plasma alcohol levels rose from 1.9 +/- 1.3 to 61.6 +/- 6.5 mg/100 ml. After placebo, plasma alcohol levels did not increase. After alcohol and placebo, supine blood pressure was unchanged; heart rate, both supine and during tilt, rose after alcohol only. 3. After alcohol, superior mesenteric artery and digital skin blood flow increased and calculated vascular resistances fell. There was no change after placebo. 4. Forearm blood flow, forearm vascular resistance and cardiac index did not change in either phase, except for a fall in cardiac index during tilt but only after alcohol. 5. In conclusion, the acute ingestion of 0.5 g of alcohol/kg body weight in normal subjects raised heart rate and actively dilated the superior mesenteric artery and digital skin vessels. There was no effect on blood pressure, cardiac output and skeletal muscle vascular tone. During head-up tilt after alcohol, there was a tendency for blood pressure to fall with a compensatory rise in heart rate.

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“…Within 15 min of food ingestion, SMA blood flow can double from 500 to 1000 ml/min [66], depending on caloric load [67], food volume and type. For example, oral alcohol causes an increased SMA blood flow compared with alcohol-free control [68]. Elevation in SMA blood flow correlates closely with amino-terminal neurotensin and norepiniphrine [67].…”

Ethanol monitoring of irrigating fluid absorption

“…Marked elevation concentration in fasting patients [57]. Ethanol increases the cutaneous and splanchnic blood flows, and a mild compensatory tachycardia Adverse effects of the ethanol or increase in cardiac output may be seen after oral The toxicology of ethanol is well established in intake of alcohol [59]. Therefore, an intravenous infusion of 5% glucose should be given slowly during the of glycine-ethanol.…”

Large-Artery Hemodynamics After Acute Alcohol Administration in Young, Healthy Volunteers

“…The effects of acute alcohol administration on blood flow and wall motion of conduit arteries in humans are disputed because both vasodilatation [1][2][3][4] and no effect 5,6 have been reported. Of importance may be the dose, mode of administration (orally versus intravenously), timing of hemodynamic measurements, and the age, gender, and health of subjects examined.…”

“…[7][8][9][10][11] A further difficulty in understanding the effects of alcohol on the hemodynamics of the conduit arteries in humans is that the few studies performed in this field have limited the investigation to the brachial artery. [1][2][3][4][5][6] Information on systemic hemodynamics and on that of other conduit arteries were not always provided or taken into account. We have previously shown that acute administration of small doses of alcohol causes carotid vasodilatation and reduction of shear stress.…”