Effects of oral administration of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 and its exopolysaccharides against influenza virus infection in mice

Nagai, Takayuki; Makino, Seiya; Ikegami, Shuji; Itoh, Hiroyuki; Yamada, Hideaki

doi:10.1016/j.intimp.2011.09.012

Cited by 125 publications

(114 citation statements)

References 29 publications

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“…For example, oral administration of acidic exopolysaccharide extracts of L. delbrueckii OLL1073R-1 to mice infected with IAV provided protection (30). In another study, the protective properties of L. plantarum strain LpYU against IAV were dependent on Toll-like receptor 2 (TLR2), which recognizes the peptidoglycan (PG) and the lipoteichoic acids (LTA) of Grampositive bacteria (29).…”

Section: Discussionmentioning

confidence: 99%

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Kechaou

Chain

Gratadoux

et al. 2013

Appl Environ Microbiol

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In this study, we developed a large-scale screening of bacterial strains in order to identify novel candidate probiotics with immunomodulatory properties. For this, 158 strains, including a majority of lactic acid bacteria (LAB), were screened by two different cellular models: tumor necrosis factor alpha (TNF-␣)-activated HT-29 cells and peripheral blood mononuclear cells (PBMCs). Different strains responsive to both models (pro-and anti-inflammatory strains) were selected, and their protective effects were tested in vivo in a murine model of influenza virus infection. Daily intragastric administrations during 10 days before and 10 days after viral challenge (100 PFU of influenza virus H1N1 strain A Puerto Rico/8/1934 [A/PR8/34]/mouse) of Lactobacillus plantarum CNRZ1997, one potentially proinflammatory probiotic strain, led to a significant improvement in mouse health by reducing weight loss, alleviating clinical symptoms, and inhibiting significantly virus proliferation in lungs. In conclusion, in this study, we have combined two cellular models to allow the screening of a large number of LAB for their immunomodulatory properties. Moreover, we identified a novel candidate probiotic strain, L. plantarum CNRZ1997, active against influenza virus infection in mice.

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Section: Discussionmentioning

confidence: 99%

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Kechaou

Chain

Gratadoux

et al. 2013

Appl Environ Microbiol

View full text Add to dashboard Cite

show abstract

“…Fermented foods and dairy products have been known contain a variety of probiotic LAB strains (Hanniffy et al, 2004;Drouault and Corthier, 2001;Parvez et al, 2006). It was demonstrated that LAB probiotic strains were able to protect against infectious diseases (Corr et al, 2007;Youn et al, 2012), and display anti-allergic effects on immune diseases in mice (Fujiwara et al, 2004;Nagai et al, 2011), chicken (Seo et al, 2012) and humans (Nagao et al, 2000;Ishida et al, 2005). However, it remains unknown whether treatments with LAB can confer improved protection.…”

Section: Introductionmentioning

confidence: 99%

Antiviral mode of action of Lactobacillus plantarum YML009 on Influenza virus H1N1

Rather

Choi

Bajpai

et al. 2015

Bangladesh J Pharmacol

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Isolation and identification of lactobacillus plantarum YML009LAB were isolated by homogenizing different types of Kimchi samples and then filtering the homogenate through a sieve (100 mesh). An appropriate volume of the filtered homogenate was diluted by decimal dilution and spread onto MRS agar (Difco laboratories, USA), followed by incubation at 37°C for 24 hours. AbstractThe development of resistance against antiviral agents has augmented a threat to public health sector. Consequently there is an expanding demand for the development of unconventional antiviral agents that could efficiently replace the existent in-use drugs. The probiotic strains of lactic acid bacteria (LAB) have earned the status of being efficient, economical and safe "nutraceutical" in health care armamentarium. A total of 2272 LAB strains were screened against H1N1 virus. The isolate YML009 displayed a pronounced antiviral activity. Sequencing and biochemical assays identified the isolate as Lactoballius plantarum which, exhibited resistance to the damage caused by the acidic conditions such as gastric juice and 5% bile salt. The anti-H1N1 activity of the strain was confirmed by hemagglutination assay and was found to display enhanced efficacy in comparison to the commercially available antiviral drug. This is a primary report on anti-influenza activity of a bacterium L. plantarum YML009.Article Info

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“…An exopolysaccharide isolated from a probiotic strain L. bulgaricus OLL1073R-1 showed potent immuno -stimulatory effect (Makino et al, 2006;NishimuraUemura et al, 2003). Further, the effect of yogurt fermented with OLL1073R-1 on the reduced risk of respiratory infections was visualized in elderly following cohort studies (Nagai et al, 2011;Makino et al, 2010). It was found that fermented yogurt augmented the NK cell activity in the subjects who had lower NK cell activity, confirming that administration of exopolysaccharide containing yogurt might have potential role to prevent the infections of influenza virus since lymphocyte natural killer cells of innate immune system have crucial role in the early host defense against various viral infections (Makino et al, 2010;Viver et al, 2008).…”

Section: Modes Of Actionmentioning

confidence: 89%

Exopolysaccharide and lactic acid bacteria: Perception, functionality and prospects

Bajpai

Rather

Majumder

et al. 2015

Bangladesh J Pharmacol

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Lactic acid bacteria exhibit the most effective potential to divert significant amount of fermentable sugars towards the biosynthesis of functional exopolysaccharide. Exopolysaccharides from lactic acid bacteria are receiving a renewed interest due to the claims of human health benefits. This review provides an update on multiple uses and production of exopolysaccharides with major emphasis on their chemical properties, characterization, and some other molecular strategies adopted for their genetics and biological tailoring to better understand the process of exopolysaccharide production along with their antiviral efficacy with multiple modes of action. Additionally, microbiological, biochemical, nutritional and biotechnological aspects of exopolysaccharide production have also been discussed. Moreover, appro-priate suggestions have been made on lactic acid bacteria improvements, leading to enhanced production with advanced modification and production process that may contribute to the economic soundness of applications in food and pharmacological industries with this promising group of biomolecules.

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Effects of oral administration of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 and its exopolysaccharides against influenza virus infection in mice

Cited by 125 publications

References 29 publications

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Antiviral mode of action of <i>Lactobacillus plantarum</i> YML009 on Influenza virus H1N1

Exopolysaccharide and lactic acid bacteria: Perception, functionality and prospects

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