Effects of one year high vs low dose oral vitamin D3 supplementation on the vitamin D status in 100 patients with postmenopausal osteoporosis

Grigorie, Daniel; Şucaliuc, Alina; Neacşu, Elena; Ivan, Mirela; Diaconescu, A.; Coles, D. R.

doi:10.1016/j.bone.2011.03.498

Cited by 3 publications

(3 citation statements)

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“…All our recruited postmenopausal women were vitamin D insufficient, suggesting that no attention is accorded to vitamin D levels, or the adherence to a prophylactic treatment is low.Even lower 25 OH vitamin D mean values in postmenopausal women with osteoporosis and MetSyn that in osteoporotic women point that the presence of MetSyn augments vitamin D insufficiency (11,12).…”

Section: Discussionmentioning

confidence: 98%

Does Obesity Protect Postmenopausal Women Against Osteoporosis?

Oros¹

2012

Acta Endo (Buc)

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Section: Discussionmentioning

confidence: 98%

Does Obesity Protect Postmenopausal Women Against Osteoporosis?

Oros¹

2012

Acta Endo (Buc)

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“…Patients with vertebral fractures had mean TBS values in the degraded range, significantly lower than those without vertebral fractures. Only 9.7% of patients with degraded or partially degraded TBS microarchitecture had normal lumbar spine T-Score scores, none with vertebral fractures [27].…”

Section: Why Should We Use the Trabecular Bone Score (Tbs) As An Eval...mentioning

confidence: 94%

“…In individuals with HPTP, the TBS is able to assess bone microarchitecture and predict fracture risk [27]. One study evaluated the significant correlation between TSB and parameters measured on HRpQCT [28].…”

Section: Why Should We Use the Trabecular Bone Score (Tbs) As An Eval...mentioning

confidence: 99%

TBS (Trabecular Bone Score) Used for Evaluation of Patients with Primary and Secondary Hyperparathyroidism

Santos¹,

Orozco²

2023

Parathyroid Glands - New Aspects

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The increase in parathyroid hormone (PTH) is related to a worse quality of bone mass. Bone densitometry, as an areal bone measurement, is not always able to assess bone microarchitecture. TBS (trabecular bone score) is a software that evaluates bone microarchitecture from the image of the lumbar spine obtained by bone densitometry. The articles have shown an excellent correlation of TBS with the risk of fragility fracture, especially in the individual who has primary hyperparathyroidism. We suggest that TBS may be an excellent method for assessing bone fragility in patients with hyperparathyroidism, especially if TBS is associated with bone densitometry.

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Comparison of Long Term Oral Supplementation With Two Dosages of Cholecalciferol on Serum 25 – Hydroxyvitamin D in Patients With Postmenopausal Osteoporosis

Grigorie¹

2019

FARMACIA

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This study reports on the efficacy of two different daily oral doses of cholecalciferol supplementation (high dose group 1000 IU/day and low dose group 500 IU/day) for one year to 100 patients with postmenopausal osteoporosis (PMO) to achieve serum concentration of 25-hydroxyvitamin D (25OHD) of 20 ng/mL and 30 ng/mL. Two thirds of the whole study group (66%) had values below 20 ng/mL and 90% had < 30ng/mL at baseline. After one year of supplementation, in the high dose group none was deficient, 85.1% had values above 20 ng/mL, half had ≥ 30 ng/mL and the mean serum 25OHD increased from 17.9 to 29.2 ng/mL (p << 0.0001). In the low dose group, 4% of the patients were still deficient, 65.2% had values above 20 ng/mL, 19% above 30 ng/mL and 25OHD increased from 19.3 to 23 ng/mL (p = 0.06). Oral cholecalciferol supplementation for one year with 1000 IU/day is adequate to achieve serum 25OHD concentrations higher than 20 ng/mL for most of the patients. If the target concentration was 30 ng/mL, the treatment is successful only for half of the patients. No vitamin D deficiency was recorded for patients under this dosage after one year. RezumatAcest studiu raportează eficacitatea suplimentării orale cu două doze diferite de colecalciferol (1000 UI și 500 UI) timp de un an la 100 de paciente cu osteoporoză de postmenopauză cu scopul de a atinge concentrații serice ale 25OHD de 20 ng/mL și 30 ng/mL. Două treimi din grupul studiat (66%) au avut valori serice ale 25OHD sub 20 ng/mL și 90% au avut valori sub 30 ng/mL. După un an de suplimentare în grupul cu doză mare niciun pacient nu a fost deficitar, 85,1% au avut valori peste 20 ng/mL, jumătate având valori ≥ 30 ng/mL, cu o creștere medie a 25OHD serice de la 17,9 ng/mL la 29,2 ng/mL (p << 0,0001). În grupul cu doză mică 4% dintre pacienți aveau încă deficit, 65,2% au avut valori peste 20 ng/mL și 19% valori peste 30 ng/mL, cu o creștere medie a 25OHD serice de la 19,3 ng/mL la 23 ng/mL (p = 0,06). Suplimentarea orală zilnică timp de un an cu 1000 UI colecalciferol este adecvată în majoritatea cazurilor pentru atingerea concentrațiilor serice de 25OHD > 20 ng/mL, iar 50% ating concentrații serice > 3 0 ng/mL.

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Effects of one year high vs low dose oral vitamin D3 supplementation on the vitamin D status in 100 patients with postmenopausal osteoporosis

Cited by 3 publications

References 0 publications

Does Obesity Protect Postmenopausal Women Against Osteoporosis?

Does Obesity Protect Postmenopausal Women Against Osteoporosis?

TBS (Trabecular Bone Score) Used for Evaluation of Patients with Primary and Secondary Hyperparathyroidism

Comparison of Long Term Oral Supplementation With Two Dosages of Cholecalciferol on Serum 25 – Hydroxyvitamin D in Patients With Postmenopausal Osteoporosis

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