Effects of omethoate on certain oxidative biomarkers in various tissues of frogs (<i>Rana ridibunda</i>) at acute exposure

Isnas, Musa; Yeğin, Eşref; Çelik, İsmail

doi:10.1177/0748233711403191

Cited by 10 publications

(5 citation statements)

References 37 publications

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“…Tadpoles are particularly useful in environmental monitoring because they develop a complete immune system and a complex circulatory system that both mature within days, rather than the years these systems take to develop in humans. Amphibians such as Bufo boreas and Rana sylvatica have been shown to be sensitive indicators of wetland quality [14], and antioxidative responses and oxidative stress levels in toads have been used as bio-indicators for pollutant exposure [15,16]. Environmental pollution is currently believed to be one of the main factors contributing to declining populations and increasing malformation rates in amphibians [17].…”

Section: Introductionmentioning

confidence: 99%

Heavy Metal Removal in a Constructed Wetland and Benefits for the Development of the Toad Bufo raddei

Si¹,

Zhang²,

Lv³

et al. 2014

Pol. J. Environ. Stud.

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Heavy metal (HM) pollution in aquatic environments is of worldwide concern because of the toxicities of HMs in animals and humans. Constructed wetlands (CWs) have successfully been used as cost-effective natural systems to remove various contaminants. However, the effects of CW on the survival of animals have not been studied in any depth. We established a CW to remove HMs from water in Baiyin City, in the upper Yellow River (YR) region, which has a highly developed mining industry. The HM removal efficiency of CW as well as its effect on the development of the toad Bufo raddei were studied. The HM removal efficiencies by the CW were in the order Cd>Pb>Zn>Cu, and the decrease of the HM concentrations in the water also caused the decrease of the HM concentrations in B. raddei toads living in the CW. The toads in the CW had larger body sizes and less oxidative stress than toads living in the YR, and no malformations were found in the toads living in the CW. These results indicate that CW systems such as that used in this study could protect amphibians from developmental problems caused by HM pollution. We recommend that CW systems are used to treat polluted water and protect amphibians.

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Section: Introductionmentioning

confidence: 99%

Heavy Metal Removal in a Constructed Wetland and Benefits for the Development of the Toad Bufo raddei

Si¹,

Zhang²,

Lv³

et al. 2014

Pol. J. Environ. Stud.

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“…Sublethal concentrations of malathion (0.006 mg/L) induced intestinal degenerative changes of the absorptive surface (villi) of the intestine of cricket frogs ( Fejervarya limnocharis ) at 10 d post exposure . Exposure of marsh frog ( Pelophylax ridibundus ) to 10 and 20 mg/L fenthion or dimethoate for 4 d increased malondialdehyde combined with a fluctuating antioxidant defense system, such as reduced glutathione levels and reduced glutathione peroxidase, glutathione‐S‐transferase, and superoxide dismutase activities in the liver, kidney, heart, and brain . Celik et al showed that the same doses of fenthion and dimethoate administed for 4 d caused fluctuations in brain acetylcholinesterase and butyrylcholinesterase activities, in addition to increased tissue myeloperoxidase, which was indicative of immunotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of an acute oral gavage method for assessment of pesticide toxicity in terrestrial amphibians

Fort

Mathis

Kee³

et al. 2017

Enviro Toxic and Chemistry

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Development of an acute oral toxicity test with a terrestrial-phase amphibian was considered necessary to remove the uncertainty within the field of agrochemical risk assessments. The bullfrog (Lithobates catesbeianus) was selected for use as it is a representative of the family Ranidae and historically this species has been used as an amphibian test model species. Prior to definitive study, oral gavage methods were developed with fenthion and tetraethyl pyrophosphate. Dimethoate and malathion were subsequently tested with both male and female juvenile bullfrogs in comprehensive acute oral median lethal dose (LD50) studies. Juvenile bullfrogs were administered a single dose of the test article via oral gavage of a single gelatin capsule of dimethoate technical (dimethoate) or neat liquid Fyfanon Technical (synonym malathion), returned to their respective aquaria, and monitored for survival for 14 d. The primary endpoint was mortality, whereas behavioral responses, food consumption, body weight, and snout-vent length (SVL) were used to evaluate indications of sublethal toxicity (secondary endpoints). Acute oral LD50 values (95% fiducial interval) for dimethoate were 1459 (1176-1810, males) and 1528 (1275-1831, females), and for malathion they were 1829 (1480-2259, males) and 1672 (1280-2183, females) mg active substance/kg body weight, respectively. Based on the results of these studies, the methodology for the acute oral gavage administration of test items to terrestrial-phase amphibians was demonstrated as being a practical method of providing data for risk assessments. Environ Toxicol Chem 2018;37:436-450. © 2017 SETAC.

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“…After assessing for inclusion (Figure S1), we extracted 2,012 effect sizes from 86 studies (Acquaroni et al, 2021; Anguiano et al, 2001; Attademo et al, 2016; Awadalla et al, 2019; Barreto et al, 2020; Bhuyan et al, 2020; Burraco and Gomez-Mestre, 2016; Carvalho et al, 2020; Chai et al, 2017; Cheng et al, 2017; Cheron et al, 2022; Costa et al, 2008; Czarniewska et al, 2003; da Silva et al, 2021; David et al, 2012; De Lima Coltro et al, 2017; Dornelles and Oliveira, 2016; Ejilibe et al, 2018; Ezemonye and Tongo, 2010; Falfushynska et al, 2015; Falfushynska et al, 2017; Ferrari et al, 2008; Ferrari et al, 2009; Ferrari et al, 2011; Freitas et al, 2017; Gillardin et al, 2009; Huang et al, 2007; Isnas et al, 2012; Jiang et al, 2019; Jones et al, 2010; Kanter and Celik, 2012; Kostaropoulos et al, 2005; Lajmanovich et al, 2018b; Lajmanovich et al, 2018a; Lajmanovich et al, 2022; Li et al, 2017; Li et al, 2018a; Li et al, 2018b; Liendro et al, 2015; Liu et al, 2006; Liu et al, 2021; Loumbourdis, 2006; Lu et al, 2021; Mardirosian et al, 2015; Marques et al, 2013; Martins et al, 2017; Melvin, 2016; Mussi and Calcaterra, 2010; Naab et al, 2001; Nascimento et al, 2021; Nasia et al, 2018; Özkol et al, 2012; Pal et al, 2018; Papadimitriou and Loumbourdis, 2002; Peltzer et al, 2019; Radovanović et al, 2017; Radovanović et al, 2021; Rosenbaum et al, 2012; Rutkoski et al, 2020; Rutkoski et al, 2021; Saad et al, 2022; Salvaterra et al, 2013; Saria et al, 2014; Shi et al, 2018; Sotomayor et al, 2015; Svartz et al, 2020; Tang et al, 2018; Trachantong et al, 2017;…”

Section: Methodsmentioning

confidence: 99%

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

Martin,

Capilla-Lasheras,

Monaghan

et al. 2023

Preprint

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Among human actions threatening biodiversity, the release of anthropogenic chemical pollutants -which have become ubiquitous in the environment- is a major concern. Chemical pollution can induce oxidative stress and damage by causing the overproduction of reactive oxygen species (ROS), and affecting the antioxidant system. In species undergoing metamorphosis (~80% of all extant animal species), antioxidant responses to chemical pollution may differ between pre- and post-metamorphic stages. Here, we meta-analysed (N = 86 studies, k = 2,012 estimates) the impact of chemical pollution on the redox balance across the three major amphibian life stages (embryo, larva, adult). Before metamorphosis, embryos and larvae activate their antioxidant pathways and do not show increased oxidative damage. In contrast, post-metamorphic individuals show unnoticeable antioxidant responses, and a marked oxidative damage in lipids. Also, type of pollutant (i.e., organic vs inorganic) promotes contrasting effects across amphibian life stages. Our findings show a divergent evolution of the redox balance in response to pollutants across life transitions of metamorphosing amphibians, likely linked to the characteristics of each life stage. Further comparative mechanistic approaches to wildlife responses to global changes will improve our understanding of these eco-evo-devo processes.

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Effects of omethoate on certain oxidative biomarkers in various tissues of frogs (Rana ridibunda) at acute exposure

Cited by 10 publications

References 37 publications

Heavy Metal Removal in a Constructed Wetland and Benefits for the Development of the Toad Bufo raddei

Heavy Metal Removal in a Constructed Wetland and Benefits for the Development of the Toad Bufo raddei

Evaluation of an acute oral gavage method for assessment of pesticide toxicity in terrestrial amphibians

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

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