Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial

MacAllister, Charles G.; Sifferman, R. L.; McClure, Scott R.; White, Gary W.; Vatistas, Nicholas J.; Holste, J. E.; Ericcson, G. F.; Cox, Jennifer L.

doi:10.1111/j.2042-3306.1999.tb05175.x

Cited by 65 publications

(67 citation statements)

References 15 publications

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“…The findings relating to the efficacy of omeprazole at day 30, concur with previous work [13,14,[29][30][31]. However, this is the first study, to the author's knowledge that has identified a reduced efficacy of omeprazole after more than 2-months of treatment.…”

Section: Discussionsupporting

confidence: 75%

A Comparison Between Omeprazole and a Dietary Supplement for the Management of Squamous Gastric Ulceration in Horses

Kerbyson

Knottenbelt

Carslake

et al. 2016

Journal of Equine Veterinary Science

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Although several studies have assessed the short-term effect of dietary supplements on the treatment and prevention of gastric ulceration in horses, few have assessed the response over a duration of more than 30 days. 2A blinded randomised non-inferiority clinical trial was conducted using forty-two Thoroughbred horses in race training with squamous ulceration of ≥ grade 2/4, randomly assigned to one of two treatment groups for a period of 90 days: omeprazole at the full label dose of 4mg/kg or the Succeed® digestive conditioning supplement. Non-inferiority analyses and Wilcoxon sign rank tests were used to analyse the data.At day 90, Succeed® was non-inferior to 4mg/kg omeprazole administered daily in terms of the proportion of horses with complete resolution of squamous ulceration.At day 30, Succeed® was found to be inferior to omeprazole in terms of the proportion of horses with grade ≤1/4 squamous ulceration. The proportion of horses with reducing squamous ulcer score (compared with day 0) was statistically significant for both treatments at days 30 and 60. At day 90 of the 17 horses on Succeed®, nine had a reducing squamous ulcer score (p-value = 0.049) and of the 19 horses on omeprazole, 10 had a reducing squamous ulcer score at day 90 (p-value = 0.091).The non-inferiority of Succeed® compared to omeprazole at 90 days for the complete resolution of squamous ulceration and the reduced efficacy of omeprazole following 90 days of treatment are likely to be of interest to practitioners managing gastric ulceration in performance horses.

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Section: Discussionsupporting

confidence: 75%

A Comparison Between Omeprazole and a Dietary Supplement for the Management of Squamous Gastric Ulceration in Horses

Kerbyson

Knottenbelt

Carslake

et al. 2016

Journal of Equine Veterinary Science

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“…Spontaneous improvement rates of 32% compared to 99% improvement in horses treated with omeprazole were found after 28 days in a similar study. The overall healing rate was 8.9% and 87% respectively in the control and omeprazole treated groups in the same study [11]. In that study the personnel that administered the medication was not able to observe the examination.…”

Section: Discussionmentioning

confidence: 95%

“…The proton pump inhibitor omeprazole has been found safe and highly efficient in both treating and preventing recurrence of gastric ulcers in horses [8-11] at dose ranges from 1–4 mg/kg. Comparison of omeprazole and histamine 2 antagonists shows superior effect of omeprazole [12,13].…”

Section: Introductionmentioning

confidence: 99%

ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses

Hellings

Larsen

2014

Acta Vet Scand

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BackgroundGastric ulceration is highly prevalent in horses, and there is a large commercial market for feed-additives and non-licenced products that claim effect for prevention and treatment of gastric ulceration. ImproWin® has been used as a feed additive in horses with anecdotal evidence that it may have some positive effects on gastric ulceration.The aim of this study was to investigate the effect of ImproWin® treatment on spontaneously occurring gastric ulcers of the squamous mucosa in Standardbred and Coldblooded trotting racehorses.The study was performed as a randomised, double-blinded, single centre study with stratified semi cross-over design with breed as stratification factors. The horses were clinically and endoscopically examined prior to start and after three weeks of treatment. The ulcerations were scored in accordance with Equine Gastric Ulcer Council (EGUC) recommendations on a 5 point scale and on a 10 cm Visual Analogue Scale (VAS). The patients were responder-classified after 3 weeks. Responders in need of ulcer treatment were randomly allocated to 2 or 4 weeks of additional treatment. Non-responders to placebo were crossed to ImproWin®.ResultsThe 5-point EGUC score and VAS recorded score was significantly reduced (P ≤ 0.01) in both groups after 3 weeks of treatment. From 3 weeks to the end of treatment the score was further significantly reduced in the ImproWin® group (P ≤ 0.05).At the end of treatment, 78% in the ImproWin® group and 54.8% in the placebo group were classified as responders. The difference was significant (P = 0.04).ConclusionsImproWin® may aid the healing process of ulcers of the gastric squamous mucosa of trotters.

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“…Regardless of the lesion type omeprazole is recommended as the treatment of choice [1] and is widely used for this purpose. Its efficacy in the treatment of ESGD in a number of clinical studies [4][5][6] appeared to support this conclusion. Its efficacy in the treatment of ESGD in a number of clinical studies [4][5][6] appeared to support this conclusion.…”

Section: Introductionmentioning

confidence: 85%

The effects of dose and diet on the pharmacodynamics of omeprazole in the horse

Sykes

Underwood

Greer

et al. 2016

Equine Veterinary Journal

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The overall efficacy of omeprazole in raising ventral gastric pH was less than previously reported. Both dose and diet may play a role in the efficacy of omeprazole in the horse. Therefore, the use of singular dosing recommendations that encompass all horse types and management conditions may not be appropriate and dosing recommendations that take into account the diet of the horse may be advantageous.

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Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial

Cited by 65 publications

References 15 publications

A Comparison Between Omeprazole and a Dietary Supplement for the Management of Squamous Gastric Ulceration in Horses

A Comparison Between Omeprazole and a Dietary Supplement for the Management of Squamous Gastric Ulceration in Horses

ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses

The effects of dose and diet on the pharmacodynamics of omeprazole in the horse

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