Effects of omentin on flap viability: an experimental research on rats

Protective effect of modafinil on skin flap survival in the experimental random-pattern skin flap model in rats: The role of ATP-sensitive potassium channels and nitric oxide pathway

“…36 , 37 eNOS and iNOS have been shown to mediate the angiogenic effects of VEGF 36 , 38 and increase SFS by inducing vasodilation. 39 A study by Kane et al , showed that iNOS knockout mice experienced prolonged delay in angiogenesis compared with wild-type mice. 37 Here, we can propose that both iNOS and nNOS are important in the SFS, as the protective effect of modafinil was reversed by administering aminoguanidine and 7-NI.…”

The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization

“…Histological examination of the flaps demonstrated angiogenesis in the experimental group, suggesting that VEGF treatment hastened the process of autonomization. Pretreatment of the flap to promote autonomization has also been investigated, such as Efeo glu et al's paper investigating the subcutaneous application of omentin to flaps before their elevation [116]. Omentin was injected at one week preoperatively in one group of rats and both 2 days before and on the day of surgery in another group.…”

“…Efeoğlu et al's paper investigating the subcutaneous application of omentin to flaps before their elevation [116]. Omentin was injected at one week preoperatively in one group of rats and both 2 days before and on the day of surgery in another group.…”