Effects of Omental Wrap on Performance of Small-Caliber High-Porosity Expanded Polytetrafluoroethylene Grafts

Prosthetic vascular grafts: Wrong models, wrong questions and no healing

“…Until 10 years ago, approximately 90% of prostheses in large animal models were as short as 5.571.2 cm (Dacron and expended polytetrafluoroethylene (ePTFE)) and 4.571.7 cm polyurethanes (PU), with a median implantation periods of 91.8717.3 days for Dacron grafts, 60.079.36 days for polytetrafluoroethylene (PTFE) grafts [11] and 907127.1 days for PU grafts. In more recent years, slightly longer grafts were implanted (64% were still shorter than 7 cm) and observation periods became shorter (medians: 28.078.9 and 14.0718.7 for ePTFE and Dacron, respectively) [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. In the small proportion of studies where truly long prostheses were implanted, they were either aorto-aortic [30][31][32][33][34][35], aorto-iliac [36][37][38][39] or aorto-femoral [40].…”

Dual Role of VEGF in Pretreated Experimental ePTFE Arterial Grafts

“…Attempts to enhance the healing of arterial grafts have relied on native structures that are themselves a source of EC and on angiogenetic factors, like omentum or bone marrow [6,7] or substances that would facilitate the attachment of EC (like collagen, fibronectin, laminin, albumin) and may be adjusted with growth factors.…”

Surface microarchitectural design in biomedical applications:In vivo analysis of tissue ingrowth in excimer laser-directed micropored scaffold for cardiovascular tissue engineering

“…Therefore, the incorporation of designed porosity into a synthetic scaffold is essential for rapid tissue regeneration, both in artificial and hybrid organs. For example, the fate of implanted artificial grafts has been discussed over the years in terms of porosity [1][2][3][4][5][6][7][8][9][10][11][12][13] : Greater porosity enhances tissue regeneration via transmural cell migration and proliferation and subsequent production of extracellular matrix. [10][11][12][13][14][15] These morphogenetic events eventually lead to a higher patency rate.…”