Effects of Omega-3 in the treatment of violent schizophrenia patients

Qiao, Yi; Man, Yi; Han, Huiqin; Liu, FengJu; Yang, Xiao; Shao, Yi; Xie, Bin; Lü, Bin

doi:10.1016/j.schres.2017.08.026

Cited by 31 publications

(24 citation statements)

References 19 publications

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“…This founding is consistent with previous studies reporting the lower fatty acid levels might be related to violence [23,59]. Although earlier studies have reported the serum cholesterol, a subclass of lipid [60], is uncorrelated with violence [61,62], more recent studies have consistently found the increased violence risk is correlated with low cholesterol concentration [19,20,63] and polyunsaturated fatty acid [26,59]. Omega-3 supplement can reduce violent behaviours in children [25], young men [64], schizophrenia patients [26] and adult prisoners [23].…”

Section: Discussionsupporting

confidence: 90%

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Dysregulation of amino acids and lipids metabolism in schizophrenia with violence

Chen

Tang³

et al. 2020

BMC Psychiatry

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Background: Many studies have related biochemical characteristics to violence and have reported schizophrenia could elevated the risk of violent behaviour. However, the metabolic characteristics of schizophrenia patients with violence (V.SC) are unclear. Methods: To explore the metabolic characteristics of schizophrenia with violence and to identify potential biomarkers, untargeted metabolomics was performed by using gas chromatography time-of-flight mass spectrometry to analyse the plasma metabolites of fifty-three V.SC and twenty-four schizophrenia patients without violence (NV.SC). Multivariate and univariate analyses were performed to identify differential metabolites and biomarkers. Violence was assessed by the MacArthur Violence Assessment Study method. Psychiatric symptoms were assessed by the Positive and Negative Syndrome Scale. Results: Multivariate analysis was unable to distinguish V.SC from NV.SC. Glycerolipid metabolism and phenylalanine, tyrosine and tryptophan biosynthesis were the differential metabolic pathways between V.SC and NV.SC. We confirmed ten metabolites and five metabolites as metabolic biomarkers of V.SC by random forest and support vector machine analysis, respectively. The biomarker panel, including the ratio of L-asparagine to L-aspartic acid, vanillylmandelic acid and glutaric acid, yielded an area under the receiver operating characteristic curve of 0.808. Conclusions: This study gives a holistic view of the metabolic phenotype of schizophrenia with violence which is characterized by the dysregulation of lipids and amino acids. These results might provide information for the aetiological understanding and management of violence in schizophrenia; however, this is a preliminary metabolomics study about schizophrenia with violence, which needs to be repeated in future studies.

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Section: Discussionsupporting

confidence: 90%

“…In addition, low levels of cholesterol associated with aggression are frequently reported [19][20][21][22]. Recently, many studies have found dietary omega-3 supplementation can reduce violent behaviours in children, young men and schizophrenia patients [23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Dysregulation of amino acids and lipids metabolism in schizophrenia with violence

Chen

Tang³

et al. 2020

BMC Psychiatry

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“…[ 33,132 ] A number of clinical trials have implicated omega‐3 PUFAs in the prevention or treatment of SCZ. [ 133,134 ] When tested in ultra‐high‐risk cohorts, omega‐3 PUFAs showed mixed results in preventing or delaying the onset of psychosis. [ 135,136 ] When used as an adjuvant treatment of antipsychotic medication, omega‐3 PUFAs could significantly improve the symptoms of SCZ.…”

Section: Mitochondrial Function As a Potential Therapeutic Target Formentioning

confidence: 99%

Mitochondrial Dysfunction in Schizophrenia

Chung

2020

BioEssays

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Schizophrenia (SCZ) is a severe neurodevelopmental disorder affecting 1% of populations worldwide with a grave disability and socioeconomic burden. Current antipsychotic medications are effective treatments for positive symptoms, but poorly address negative symptoms and cognitive symptoms, warranting the development of better treatment options. Further understanding of SCZ pathogenesis is critical in these endeavors. Accumulating evidence has pointed to the role of mitochondria and metabolic dysregulation in SCZ pathogenesis. This review critically summarizes recent studies associating a compromised mitochondrial function with people with SCZ, including postmortem studies, imaging studies, genetic studies, and induced pluripotent stem cell studies. This review also discusses animal models with mitochondrial dysfunction resulting in SCZ-relevant neurobehavioral abnormalities, as well as restoration of mitochondrial function as potential therapeutic targets. Further understanding of mitochondrial dysfunction in SCZ may open the door to develop novel therapeutic strategies that can address the symptoms that cannot be adequately addressed by current antipsychotics alone.

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“…These initial promising findings allow us to take into consideration the use of non-pharmacological compounds for early interventions in young people at risk for psychosis [42]. The results obtained so far about PUFAs as an add-on strategy in the treatment of schizophrenia are controversial; while several studies [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] produced favorable data, some others [58][59][60][61] showed no significant differences in clinical outcomes.…”

Section: Psychotic Symptomsmentioning

confidence: 99%

“…Studies that evaluated the effects of PUFAs on impulsivity and aggressiveness in major psychiatric disorders indicated that the addition of rather low doses of omega-3 fatty acids (EPA 0.54 g/day + DHA 0.36 g/day) to antipsychotic treatment might reduce agitation and violent behaviors in inpatients with schizophrenia in the chronic phase [61]. Single therapy with omega -3 fatty acids (EPA 0.93 g/day + DHA 0.29 g/day) showed an improvement of impulsive dyscontrol and aggressiveness in patients affected by ADHD (attention deficit hyperactivity disorder) [151,152] and in patients affected by BPD [133,134].…”

Section: Impulsive and Aggressive Symptomsmentioning

confidence: 99%

Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology

Bozzatello

Rosa

Rocca

et al. 2020

IJMS

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The usefulness of polyunsaturated fatty acids on inflammatory, cardiovascular, and the nervous system was studied in the last decades, but the mechanisms underlying their benefic properties are still partially unknown. These agents seem to express their action on the membrane phospholipid composition and permeability and modulation of second messenger cascades. In psychiatry, the efficacy and tolerability of omega-3 fatty acids were investigated in several psychiatric disorders, including major depression, bipolar disorder, personality disorders, high-risk conditions to develop psychosis, attention-deficit hyperactivity disorder, and autism spectrum disorders. Initial findings in this field are promising, and some relevant questions need to be addressed. In particular, the effects of these agents on the main symptom dimensions have to be investigated in a trans-diagnostic perspective. The present systematic review is aimed to examine the available data on the efficacy of omega-3 fatty acids on domains of psychotic symptoms, affective symptoms, impulsivity, and aggressiveness, and harmful behaviors, and suicide risk.

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Effects of Omega-3 in the treatment of violent schizophrenia patients

Cited by 31 publications

References 19 publications

Dysregulation of amino acids and lipids metabolism in schizophrenia with violence

Dysregulation of amino acids and lipids metabolism in schizophrenia with violence

Mitochondrial Dysfunction in Schizophrenia

Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology

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