Effects of omega-3 fatty acids and metformin combination on diabetic cardiomyopathy in rats through autophagic pathway

Eraky, Salma M.; Ramadan, Nehal M.

doi:10.1016/j.jnutbio.2021.108798

Cited by 9 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drug therapy for patients with DMT2 includes the use of drugs such as metformin, which improves insulin sensitivity in tissues such as the liver and skeletal muscle. N-3 PUFAs supplementation alone or in combination with metformin restores metabolism by increasing the PGC-1α expression, preventing mitochondrial degeneration, having a hypoglycemic effect, and improving the myocardial structure to prevent cardiomyopathies in rats [50]. Depending on the genes altered in DMT2, the response to n-3 PUFA supplementation may vary.…”

Section: Nutrigenomic Effects Of Dietary Lipids On Pparγ and Plin1mentioning

confidence: 99%

PPARγ Gene as a Possible Link between Acquired and Congenital Lipodystrophy and its Modulation by Dietary Fatty Acids

et al. 2022

View full text Add to dashboard Cite

Lipodystrophy syndromes are rare diseases that could be of genetic or acquired origin. The main complication of lipodystrophy is the dysfunction of adipose tissue, which leads to an ectopic accumulation of triglycerides in tissues such as the liver, pancreas and skeletal muscle. This abnormal fat distribution is associated with hypertriglyceridemia, insulin resistance, liver steatosis, cardiomyopathies and chronic inflammation. Although the origin of acquired lipodystrophies remains unclear, patients show alterations in genes related to genetic lipodystrophy, suggesting that this disease could be improved or aggravated by orchestrating gene activity, for example by diet. Nowadays, the main reason for adipose tissue dysfunction is an imbalance in metabolism, caused in other pathologies associated with adipose tissue dysfunction by high-fat diets. However, not all dietary fats have the same health implications. Therefore, this article aims to summarize the main genes involved in the pathophysiology of lipodystrophy, identify connections between them and provide a systematic review of studies published between January 2017 and January 2022 of the dietary fats that can modulate the development of lipodystrophy through transcriptional regulation or the regulation of protein expression in adipocytes.

show abstract

Section: Nutrigenomic Effects Of Dietary Lipids On Pparγ and Plin1mentioning

confidence: 99%

PPARγ Gene as a Possible Link between Acquired and Congenital Lipodystrophy and its Modulation by Dietary Fatty Acids

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Over the past few years, a various research demonstrated the e cacy of omega 3 supplementation in treating various diseases as adding omega-3 to simvastatin with dietary modi cations improved non-HDL-C and other lipid and lipoprotein parameters more than using simvastatin alone in patients with elevated serum triglyceride (TG) [14]. Omega 3 have a synergistic cardio-protection when added to metformin by improving myocardial ultrastructure and its autophagic activity [15]. Other studies reported that high dose omega-3 fatty acid administration ameliorates acute and chronic vascular in ammation and may lower the incidence of heart failure [16,17], slows down the progression of atherosclerosis [18] and might have anti-in ammatory effects against CVD in HD patients [19].…”

Section: Introductionmentioning

confidence: 99%

Omega 3 fatty acids effect on the vascular calcification biomarkers fetuin A and osteoprotegerin in hemodialysis patients

et al. 2021

View full text Add to dashboard Cite

Chronic Renal failure patients on dialysis are at a high risk of death due to vascular calci cation (VC).This study aimed at investigating the effect of omega3-fatty acids on the vascular calci cation biomarkers fetuin-A and Osteoprotegerin (OPG) in patients with chronic renal failure (CRF) who are undergoing hemodialysis. This prospective, open-label, controlled, parallel study included 60 hemodialysis patients who were randomized to receive either omega-3 fatty acids capsule along with their standard care of treatment (omega-3 group) or their standard care of treatment only (control group).Serum levels of fetuin-A, OPG, calcium, phosphorus, hemoglobin, parathyroid hormone (PTH), blood urea nitrogen (BUN), albumin (ALB), serum creatinine (SCr), and serum triglycerides (TG) were measured at baseline and after six months of intervention and follow-up of both groups. Signi cantly increased levels of fetuin-A and OPG (p<0.001) were observed in the omega-3 group six months after the intervention compared with the control group. Levels of calcium, phosphorous, hemoglobin, parathyroid hormone, BUN, albumin, SCr, and TG were not signi cantly changed in the omega-3 group or the control group after six months of intervention. Our study concluded that omega-3 may have a clinically bene cial effect in decreasing cardiovascular events by increasing the levels of the protective vascular calci cation inhibitors fetuin-A and osteoprotegerin in chronic renal failure patients who are undergoing hemodialysis.

show abstract

Secreted frizzled-related protein 2 ameliorates diabetic cardiomyopathy by activating mitophagy

Zheng,

Li,

Huang

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

Effects of omega-3 fatty acids and metformin combination on diabetic cardiomyopathy in rats through autophagic pathway

Cited by 9 publications

References 61 publications

PPARγ Gene as a Possible Link between Acquired and Congenital Lipodystrophy and its Modulation by Dietary Fatty Acids

PPARγ Gene as a Possible Link between Acquired and Congenital Lipodystrophy and its Modulation by Dietary Fatty Acids

Omega 3 fatty acids effect on the vascular calcification biomarkers fetuin A and osteoprotegerin in hemodialysis patients

Secreted frizzled-related protein 2 ameliorates diabetic cardiomyopathy by activating mitophagy

Contact Info

Product

Resources

About