Effects of olprinone, a new phosphodiesterase inhibitor, on gastric intramucosal acidosis and systemic inflammatory responses following hypothermic cardiopulmonary bypass

Yamaura, Ken; Akiyoshi, Kozaburo; Irita, Kazuo; Taniyama, Takuro; Takahashi, Shosuke

doi:10.1034/j.1399-6576.2001.045004427.x

Cited by 12 publications

(6 citation statements)

References 58 publications

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“…Yamaura examined the systemic inflammatory responses of serum interleukin-6, serum interleukin-10, and leukocyte counts in 23 patients undergoing cardiac surgery with cardiopulmonary bypass [51]. Olprinone at 0.2 µg/kg/min significantly increased levels of serum interleukin-10 and reduced the extent of leukocytosis, but did not affect serum interleukin-6 levels.…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

“…Yamaura et al [51] proposed that olprinone could suppress gastric intramucosal acidosis in 23 patients undergoing cardiac surgery with cardiopulmonary bypass. The gastric intramucosal pH, which showed a transient decrease after cardiopulmonary bypass, did not show significant changes with the administration either olprinone or milrinone [51,54].…”

Section: Splanchnic Organsmentioning

confidence: 99%

“…The PDE 3 inhibitors olprinone and milrinone inhibit systemic inflammation by directly inhibiting macrophages, which are known to exhibit high PDE 3 activity [51,54,69,70]. Yamaura examined the systemic inflammatory responses of serum interleukin-6, serum interleukin-10, and leukocyte counts in 23 patients undergoing cardiac surgery with cardiopulmonary bypass [51].…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

“…Inadequate oxygen delivery to splanchnic organs can impair liver and intestinal mucous function, resulting in high mortality [46][47][48]. Hepatic venous oxygen saturation and gastric intramucosal pH, both of which decline under stress, have been reported to be useful indices of oxygen balance in hepatosplanchnic organs [49][50][51]. One important factor in maintaining adequate oxygen delivery is increased cardiac output.…”

Section: Splanchnic Organsmentioning

confidence: 99%

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The Effects of Olprinone, a Phosphodiesterase 3 Inhibitor, on Systemic and Cerebral Circulation

Ueda¹,

Mizushige

2006

CVP

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Olprinone, a phosphodiesterase (PDE) 3 inhibitor, is used to treat heart failure due to its positive inotropic and vasodilative effects. Selective inhibition of the PDE 3 isozyme increases intracellular adenosine 3;5;-cyclic monophosphate and enhances Ca(2+) influx into cardiac muscle cells. The most significant advantage of PDE 3 inhibitors is their ability not only to enhance myocardial contraction, but to reduce, through vasodilatory action, the stress to which the heart is subjected. In peripheral vessels, the decrease of cytosolic free Ca(2+) induces the vasorelaxation of vascular smooth muscle cells. In this way, olprinone reduces mean aortic and pulmonary artery pressures. Additionally, olprinone exerts differential vasodilatory effects on peripheral vessels in each organ, based on the differences in the distribution of PDE 3 among the organs. With respect to the cerebral circulation, olprinone augments blood flow in the cerebral cortex through direct vasodilatory effects on small cerebral arteries or arterioles. Olprinone increases hepatosplanchnic blood flow and improves oxygen supply. While long-term therapy with PDE 3 inhibitors in patients with chronic heart failure may accelerate the progress of the underlying disease and provoke serious ventricular arrhythmia, olprinone shows good potential for short-term treatment in patients who have experienced severe heart failure or patients who have undergone cardiac surgery.

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Section: Anti-inflammatory Effectmentioning

confidence: 99%

Section: Splanchnic Organsmentioning

confidence: 99%

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Section: Splanchnic Organsmentioning

confidence: 99%

See 2 more Smart Citations

The Effects of Olprinone, a Phosphodiesterase 3 Inhibitor, on Systemic and Cerebral Circulation

Ueda¹,

Mizushige

2006

CVP

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“…26 The use of the newly developed olprinone was associated with reduced IL-10 levels and moderate reduction in gastric acidosis intraoperatively. 27 Pentoxifylline, a methyl xanthine derivative, is known for its protective effects on endothelium. When given to cardiac surgical patients in the perioperative period, its use was associated with reduced production of cytokines, reduced leukocyte activation and sequestration in the lungs and improvement in indices of pulmonary injury.…”

Section: Phosphodiesterase Inhibitorsmentioning

confidence: 99%

A review of anti-inflammatory strategies in cardiac surgery

Asimakopoulos¹,

Gourlay

2003

Perfusion

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It is generally accepted that cardiac surgery is frequently associated with the development of systemic inflammatory response. This phenomenon is very variable clinically, and can be detected by measuring plasma concentrations of certain inflammatory markers. Complement component, cytokines and adhesion molecules are examples of these markers. Systemic inflammation can be potentially damaging to major organs. Several anti-inflammatory strategies have been used in recent years, aiming to attenuate the development of systemic inflammatory response. This article summarizes recently published literature concerning the use of anti-inflammatory techniques and pharmacological agents in cardiac surgery. In particular, the anti-inflammatory effects of off-pump surgery, leukocyte filtration, corticosteroids, aprotinin, phosphodiesterase inhibitors, dpoexamine, H2 antagonists and ACE inhibitors are reviewed. The overall conclusion is that although certain strategies reduce plasma levels of inflammatory mediators, convincing evidence of significant clinical benefits is yet to come.

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Pretreatment with olprinone hydrochloride, a phosphodiesterase III inhibitor, attenuates lipopolysaccharide-induced lung injury via an anti-inflammatory effect

Koike

Qutab

Tsuchida

et al. 2008

Pulmonary Pharmacology & Therapeutics

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Effects of olprinone, a new phosphodiesterase inhibitor, on gastric intramucosal acidosis and systemic inflammatory responses following hypothermic cardiopulmonary bypass

Abstract: Our results suggest that olprinone at 0.2 microg x kg(-1) x min(-1) suppresses gastric intramucosal acidosis and systemic inflammation following CPB.

Cited by 12 publications

References 58 publications

The Effects of Olprinone, a Phosphodiesterase 3 Inhibitor, on Systemic and Cerebral Circulation

The Effects of Olprinone, a Phosphodiesterase 3 Inhibitor, on Systemic and Cerebral Circulation

A review of anti-inflammatory strategies in cardiac surgery

Pretreatment with olprinone hydrochloride, a phosphodiesterase III inhibitor, attenuates lipopolysaccharide-induced lung injury via an anti-inflammatory effect

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