Effects of Olopatadine Hydrochloride on the Cutaneous Vascular Hyperpermeability and the Scratching Behavior Induced by Poly-L-Arginine in Rats

Abstract

Intradermal injections of poly-L-arginine induce cutaneous vascular hyperpermeability and scratching behavior in rats. Recently, we elucidated that the plasma extravasation involved both histamine and substance P, while the scratching behavior involved substance P, but not histamine. This study examined the effects of olopatadine hydrochloride (olopatadine), an antiallergic drug with histamine H1-antagonistic action, on the poly-L-arginine-induced responses. Olopatadine (1 mg/kg, p.o.) significantly inhibited both the plasma extravasation and the scratching behavior, suggesting that its inhibitory effects are mediated by the suppression of neuropeptidergic action as well as histaminic action. Olopatadine seems to be a novel-type drug for the treatment of dermatitis.

Olopatadine hydrochloride suppresses the rebound phenomenon after discontinuation of treatment with a topical steroid in mice with chronic contact hypersensitivity

“…Indeed, olopatadine has been shown to inhibit the expression of IL‐4 mRNA in rat basophilic leukemia (RBL)‐2 mast cells [21]. In addition, olopatadine inhibits pruritus by reducing the tachykinin release from peripheral sensory nerve endings [22] as well as by blocking the action of histamine on its receptors in the skin.…”

“…Indeed, olopatadine has been shown to inhibit the expression of IL-4 mRNA in rat basophilic leukemia (RBL)-2 mast cells [21]. In addition, olopatadine inhibits pruritus by reducing the tachykinin release from peripheral sensory nerve endings [22] as well as by blocking the action of histamine on its receptors in the skin. Kimata [23] described the increased expression of Th2 cytokine mRNA in peripheral blood mononuclear cells obtained from patients with AD during the rebound phenomenon after discontinuation of the treatment with a topical steroid.…”

Effect of Olopatadine and Other Histamine H₁ Receptor Antagonists on the Skin Inflammation Induced by Repeated Topical Application of Oxazolone in Mice

“…In addition to its potent histamine H 1 receptor antagonistic effect, previous studies have demonstrated that olopatadine inhibits the release of tachykinin [6] , interleukin (IL)-6, IL-8 [7] and tumor necrosis factor-␣ [8] .…”

Synergetic Effects of Prednisolone and Olopatadine on Atopic Dermatitis Model of Hairless Mice

“…In clinical settings, chlorpheniramine is regarded as ineffective against itching and/or scratching in atopic dermatitis patients [17] . On the other hand, olopatadine decreased the production of various cytokines, and tachykinin and chemical mediator release had inhibitory effects [18][19][20][21] . Therefore, the inhibition of scratching behavior by olopatadine induced by TNCB might have been generated by the above pharmacological properties.…”