Effects of Olive Oil and Grape Seed Oil on Lipid Profile and Blood Pressure in Patients with Hyperlipidemia: A Randomized Clinical Trial

Abstract

Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil; 2) consume 20 ml/day grape seed oil; 3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald's formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m 2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.

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“…Therefore, grape seed oil has been reported as a suitable dietary supplement that may prevent or improve physiological disorders related to chronic diseases [ 35 , 109 ]. Notably, many questions related to bioavailability, dose response, and side effects in humans are still to be answered [ 125 , 126 ]. Nevertheless, we will address the main nutraceutical activities with the responsible oil components.…”

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Review Article: Biochemical Hypolipidemic Action of Some Herbs and Medicinal Plants

“…Both seeds and fruit of the grape are commonly used as functional medicinal plant caused by anti dyslipidemic effect and antioxidant activities via free radical scavenging [25]. Red grape seed extract involves oligomeric proanthocynaidins and procyanidins as a major class of The pivotal biochemical action of grape seeds refleted by not only the rich content of polyphenols but also the replacement of saturated fatty acids by polyunsaturated fatty acids whereby all grape seeds has high percent of linoleic acid (60%-75%) and it is recognized for shifting lipid profile towards balance [24].…”