Effects of olfactory bulb ablation upon emotionality and muricidal behavior in four rat strains.

The effects of colony differences and olfactory bulb lesions on muricide in rats

“…The subjects were then decapitated, the tops of the skulls were removed, and the entire heads were placed in formalin for at least 1 week prior to removal of brains. The extent of damage was assessed by comparison to line drawings using the method described by Thorne et al (1973).…”

“…The results did not provide conclusive evidence for an artifact. The overall results were discussed in terms of generalizing from studies employing rats from different colonies, and suggestions for improving generality were made.Recently, the strain of rat used in research has been found to be an important variable (e.g., Richman, Gulkin, & Knoblock, 1972; Thorne, Aaron, & Latham, 1973;Wilcock & Broadhurst, 1967). For example, Thome et al (I973) found differences between strains in emotionality and in the rate of mouse killing observed after olfactory bulb (OB) damage.…”

“…Recently, the strain of rat used in research has been found to be an important variable (e.g., Richman, Gulkin, & Knoblock, 1972; Thorne, Aaron, & Latham, 1973; Wilcock & Broadhurst, 1967). For example,Thome et al (I973) found differences between strains in emotionality and in the rate of mouse killing observed after olfactory bulb (OB) damage.…”

The effect of time of test on muricide, irritability, and open-field activity in the rat

“…The home cage was then carried to a table on which the handling test was administered. The test consisted of rating the animals on a five-item scale used by Thorne, Aaron, and Latham (1973). Each of the five measures was rated on a 4-point scale (0-3), and the ratings of the components were summed to give a daily total.…”

The effects of simultaneous and serial lesions of the olfactory bulbs on muricide, irritability, and open-field activity in Long-Evans female rats

“…For example, OB damage has been found to increase muricide in nonkiller rats (e.g., Kar!i, Vergnes, & Didiergeorges, 1969;Malick, 1970;Thorne, Aaron, & Latham, 1973, 1974, produce hyperirritability (e.g., Douglas, Isaacson, & Moss, 1969;Malick, 1970), and cause hyperactivity in the open-field test (e.g., Burge & Edwards, 1976;Klein & Brown, 1969;Sieck, 1972). There is evidence that hyperirritability is a function of the extent of damage to the olfactory system, and destruction of the olfactory bulbs alone often results in no change in irritability (e.g., Bandler & Chi, 1972;Phillips, 1970;Thorne et al, ,1974.…”