Effects of oleanolic acid on inflammation and metabolism in diabetic rats

İskender, Hatice; Dokumacıoğlu, Eda; Kapakin, Kübra Asena Terim; Yenice, Güler; Mohtare, Behzat; Bolat, İsmail; Hayırlı, A.

doi:10.1080/10520295.2021.1954691

Cited by 16 publications

(9 citation statements)

References 40 publications

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“…Once the duplicates were removed, 2702 records were screened, from which 2645 were excluded. Then, 57 reports were sought for retrieval, and 5 of them were not retrieved [ 33 , 34 , 35 , 36 , 37 ]. Later, 52 full-text articles were read to assess their eligibility, and finally 16 studies were included.…”

Section: Resultsmentioning

confidence: 99%

Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review

et al. 2022

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Oleanolic acid (OA) is a natural triterpene widely found in olive leaves that possesses antioxidant, anti-inflammatory, and insulin-sensitizing properties, among others. These OA characteristics could be of special interest in the treatment and prevention of insulin resistance (IR), but greater in-depth knowledge on the pathways involved in these properties is still needed. We aimed to systematically review the effects of OA on the molecular mechanisms and signaling pathways involved in the development of IR and underlying oxidative stress in insulin-resistant animal models or cell lines. The bibliographic search was carried out on PubMed, Web of Science, Scopus, Cochrane, and CINHAL databases between January 2001 and May 2022. The electronic search produced 5034 articles but, after applying the inclusion criteria, 13 animal studies and 3 cell experiments were identified, using SYRCLE’s Risk of Bias for assessing the risk of bias of the animal studies. OA was found to enhance insulin sensitivity and glucose uptake, and was found to suppress the hepatic glucose production, probably by modulating the IRS/PI3K/Akt/FoxO1 signaling pathway and by mitigating oxidative stress through regulating MAPK pathways. Future randomized controlled clinical trials to assess the potential benefit of OA as new therapeutic and preventive strategies for IR are warranted.

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Section: Resultsmentioning

confidence: 99%

Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review

et al. 2022

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“…On the other hand, the consumption of both vegetable oils (OPO and SO) had no significant effect on serum MDA levels, a widely used marker of lipid peroxidation, in both study groups ( Supplementary Table S2 ). There are previous studies demonstrating how triterpenic acids (oleanolic, ursolic, and maslinic acids) [ 61 , 62 , 63 , 64 ] and squalene (components of OPO) [ 65 ] decrease MDA levels in various animal models of hypertension, inflammation, or diabetes. However, the high, pharmacological dose of pure triterpenic acids and squalene administered to the experimental animals, as well as the pathologies of the murine models used, limit potential comparisons with the present nutritional human intervention study.…”

Section: Discussionmentioning

confidence: 99%

Effect of Olive Pomace Oil on Cardiovascular Health and Associated Pathologies

et al. 2022

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Background: olive pomace oil (OPO) is a nutritionally relevant fat due to its high oleic acid content (C18:1) and the presence of a wide range of minor bioactive components. Although numerous in vitro and preclinical studies have been developed to study some of its characteristic components, the health effect of prolonged OPO consumption is unknown. Methods: a randomised, blinded, cross-over, controlled clinical trial was carried out in 31 normocholesterolemic and 37 hypercholesterolemic subjects. Participants consumed 45 g/day of OPO or sunflower oil (SO) for 4 weeks, each preceded by a 3-week run-in/wash-out phase with corn oil (CO). Results: regular consumption of OPO and SO had no statistically significant effect on any of the markers related to lipid profile, blood pressure, and endothelial function in both groups, except for eNOS levels, which were close to statistical significance due to the effect of oil (OPO and SO) (p = 0.083). A decrease in visceral fat (p = 0.028) in both groups was observed after OPO intake, accompanied by an increment of leptin (p = 0.017) in the hypercholesterolemic group. Conclusion: reducing visceral fat after prolonged OPO intake might contribute to improve cardiometabolic status, with a potentially positive effect on the vascular tone. Further clinical trials are needed to confirm the present results.

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“…In the NUTRAOLEUM study, an optimized virgin olive oil (OVOO) enriched in phenolic compounds and a functional olive oil (FOO) enriched in both phenolic compounds and triterpenes were compared with VOO in healthy adults; none of the oils showed any effect on TC or LDL-C after daily consumption of 30 mL for 3 weeks, and only OVOO caused a significant increase in HDL-C [13]. Trials in several animal models have also reported reductions in serum TC, TG, LDL-C or VLDL-C and/or increased HDL-C concentrations following oral administration of different doses (15-100 mg/kg/d) of MA [reviewed in 26], OA (5-25 mg/kg/d) [25][26][27][28][29] or high (200 mg/kg/d) but not low (50 mg/kg/d) doses of ursolic acid (UA) [30]. However, results from these animal studies cannot be extrapolated to humans, since the amounts of triterpenic acids fed to experimental animals were much higher than those consumed by the volunteers in the present study, amounting to less than 10 mg/d.…”

Section: Discussionmentioning

confidence: 99%

Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers

et al. 2022

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Purpose This study aimed to assess the effect of dietary consumption of olive pomace oil (OPO) on blood lipids (primary outcome) and other cardiovascular disease (CVD) risk factors (blood pressure, inflammation and endothelial function as secondary outcomes). Methods A randomized, controlled, blind, crossover intervention was carried out in healthy and at-risk (hypercholesterolemic) subjects. Participants consumed daily 45 g of OPO or high-oleic acid sunflower oil (HOSO) as control oil during 4 weeks. Results OPO significantly reduced low-density lipoprotein cholesterol (LDL-C; P = 0.003) and apolipoprotein B (Apo B; P = 0.022) serum concentrations, and LDL/HDL ratio (P = 0.027) in healthy and at-risk volunteers. These effects were not observed with HOSO. Blood pressure, peripheral artery tonometry (PAT), endothelial function and inflammation biomarkers were not affected. Conclusions Regular consumption of OPO in the diet could have hypolipidemic actions in subjects at cardiovascular risk as well as in healthy consumers, contributing to CVD prevention. Clinical trial registry NCT04997122, August 8, 2021, retrospectively registered.

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Effects of oleanolic acid on inflammation and metabolism in diabetic rats

Cited by 16 publications

References 40 publications

Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review

Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review

Effect of Olive Pomace Oil on Cardiovascular Health and Associated Pathologies

Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers

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