Effects of Oestrogen Treatment on Skeletal Response to Exercise in the Hips and Spine in Postmenopausal Women: A Meta-Analysis

Zhao, Rongsheng; Xu, Zhengang; Zhao, Meihua

doi:10.1007/s40279-015-0338-3

Cited by 17 publications

(8 citation statements)

References 43 publications

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“…In this population, hormone replacement improves muscle mass and function by improving muscle repair, and the response to feeding and exercise. Bone mass and function is also improved by HRT (Zhao et al, 2015). The problem is that long term HRT use is associated with decreased tendon cross-sectional area, especially in an active population (Cook et al, 2007).…”

Section: Practical Considerations To Maximize Performance and Minimizmentioning

confidence: 99%

Effect of Estrogen on Musculoskeletal Performance and Injury Risk

2019

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Estrogen has a dramatic effect on musculoskeletal function. Beyond the known relationship between estrogen and bone, it directly affects the structure and function of other musculoskeletal tissues such as muscle, tendon, and ligament. In these other musculoskeletal tissues, estrogen improves muscle mass and strength, and increases the collagen content of connective tissues. However, unlike bone and muscle where estrogen improves function, in tendons and ligaments estrogen decreases stiffness, and this directly affects performance and injury rates. High estrogen levels can decrease power and performance and make women more prone for catastrophic ligament injury. The goal of the current work is to review the research that forms the basis of our understanding how estrogen affects muscle, tendon, and ligament and how hormonal manipulation can be used to optimize performance and promote female participation in an active lifestyle at any age.

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Section: Practical Considerations To Maximize Performance and Minimizmentioning

confidence: 99%

Effect of Estrogen on Musculoskeletal Performance and Injury Risk

2019

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“…In part support of this notion, a meta-analysis of six intervention trials in postmenopausal women aged 52 to 68 years found that combined hormone replacement therapy (HRT) and exercise was associated with greater improvements in femoral neck and lumbar spine BMD than exercise alone. 63 The mixed findings with regard to the effects of weightbearing exercise on bone may be related to differences in the exercises prescribed and/or technique used, the non-progressive nature of some programs, a failure to incorporate multi-directional or novel loading activities and/or compliance issues associated with other comorbidities (e.g. pain from osteoarthritis).…”

Section: Weight-bearing Impact Exercisementioning

confidence: 99%

Exercise for the prevention of osteoporosis in postmenopausal women: an evidence-based guide to the optimal prescription

Daly

Via

Duckham

et al. 2019

Brazilian Journal of Physical Therapy

157

112

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Background: Osteoporosis and related fragility fractures are a global public health problem in which pharmaceutical agents targeting bone mineral density (BMD) are the first line of treatment. However, pharmaceuticals have no effect on improving other key fracture risk factors, including low muscle strength, power and functional capacity, all of which are associated with an increased risk for falls and fracture, independent of BMD. Targeted exercise training is the only strategy that can simultaneously improve multiple skeletal and fall-related risk factors, but it must be appropriately prescribed and tailored to the desired outcome(s) and the specified target group. Objectives: In this review, we provide an overview of the general principles of training and specific loading characteristics underlying current exercise guidelines for the prevention of osteoporosis, and an update on the latest scientific evidence with regard to the type and dose of exercise shown to positively influence bone mass, structure and strength and reduce fracture risk in postmenopausal women.

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“…However, because mechanical responsiveness decreases with age, determining whether these differences are due solely to estrogen status is difficult. Estrogen treatment and exercise increase bone mass more than exercise alone among postmenopausal women, but how these differences compare to premenopausal women is unclear …”

Section: Introductionmentioning

confidence: 99%

“…Estrogen treatment and exercise increase bone mass more than exercise alone among postmenopausal women, but how these differences compare to premenopausal women is unclear. 17 Animal models of menopause and hormone depletion are useful tools for studying the role of estrogen and other hormones in mechanical adaptation, and include ovariectomy (OVX) and orchidectomy (ORX). In rats, for instance, estrogen treatment reduced skeletal responsiveness to exercise and mechanical loading, 18 and OVX-induced estrogen loss increased responsiveness.…”

Section: Introductionmentioning

confidence: 99%

Mouse models to evaluate the role of estrogen receptor α in skeletal maintenance and adaptation

Rooney

Meulen

2017

Annals of the New York Academy of Sciences

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Estrogen signaling and mechanical loading have individual and combined effects on skeletal maintenance and adaptation. Previous work investigating estrogen signaling both in vitro and in vivo using global estrogen receptor α (ERα) gene knockout mouse models has provided information regarding the role of ERα in regulating bone mass and adaptation to mechanical stimulation. However, these models have inherent limitations that confound interpretation of the data. Therefore, recent studies have focused on mice with targeted deletion of ERα from specific bone cells and their precursors. Cell stage, tissue type, and mouse sex all influence the effects of ERα gene deletion. Lack of ERα in osteoblast progenitor and precursor cells generally affects the periosteum of female and male mice. The absence of ERα in differentiated osteoblasts, osteocytes, and osteoclasts in mice generally resulted in reduced cancellous bone mass, with differing reports of the effect by animal sex and greater deficiencies in bone mass typically occurring in cancellous bone in female mice. Limited data exist for the role of bone cell-specific ERα in skeletal adaptation in vivo. Cell-specific ERα gene knockout mice provide an excellent platform for investigating the function of ERα in regulating skeletal phenotype and response to mechanical loading by sex and age.

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Effects of Oestrogen Treatment on Skeletal Response to Exercise in the Hips and Spine in Postmenopausal Women: A Meta-Analysis

Abstract: Our findings indicate that oestrogen treatment significantly increases the skeletal response to exercise training in both the hips and the spine in postmenopausal women, which implies that the combination of oestrogen administration and exercise may generate greater effects.

Cited by 17 publications

References 43 publications

Effect of Estrogen on Musculoskeletal Performance and Injury Risk

Effect of Estrogen on Musculoskeletal Performance and Injury Risk

Exercise for the prevention of osteoporosis in postmenopausal women: an evidence-based guide to the optimal prescription

Mouse models to evaluate the role of estrogen receptor α in skeletal maintenance and adaptation

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