Effects of oestradiol on sex hormone binding globulin

Odlind, Viveca; Elamsson, Kerstin; Englund, D. E.; Victor, Arne; Johansson, Elof D. B.

doi:10.1530/acta.0.1010248

Cited by 54 publications

(24 citation statements)

References 9 publications

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“…Our results are consistent with those of previous investigators [1,4,5] but differ from those who reported SHBG levels were increased during the preovulatory and luteal phases of the normal menstrual cycle [6]. The discrepancy regarding SHBG production appears to reflect the individual's metabolic and nutritional status, growth, and aging rather than temporary fluctuations in sex steroids [21], and/or is explained by genetic factors [22,23].…”

Section: Discussionsupporting

confidence: 88%

“…The plasma concentration of SHBG reflects the balance between estrogen and androgen. No changes in SHBG have been reported to occur during a normal menstrual cycle despite significant increases in preovulatory E 2 levels [1,4,5], however, conflicting findings have been reported [6].…”

mentioning

confidence: 99%

“…A pronounced increase in SHBG levels has been documented in nonpregnant women when circulating E 2 is increased to particularly high levels, as during gonadotropin treatment [4,5,7]. Follicular fluid also has high levels of SHBG during ovulation induction, presumably to regulate the bioactivity of ovarian steroids for follicular and embryo development and maturation [8][9][10][11].…”

mentioning

confidence: 99%

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Relationship between Sex Hormone-Binding Globulin and Pregnancy Outcome in Women Undergoing Controlled Ovarian Hyperstimulation for Assisted Reproduction

Lin

Sun

2005

Endocr J

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Abstract. The purpose of this study was to determine whether the changes of sex hormone-binding globulin (SHBG) affect the pregnancy outcome in women undergoing controlled ovarian hyperstimulation (COH) for assisted reproduction. Forty-five infertile women who were undergoing pituitary desensitization and COH for in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) and 19 women with normal menstrual cycles participated in the study. Fasting blood samples of the follicular and luteal phases, including follicular fluid during oocyte retrieval, were obtained for determination of estradiol (E 2 ), progesterone (P 4 ), testosterone (T), and SHBG concentrations. The SHBG levels increased progressively during the course of COH, but remained constant throughout normal menstrual cycles. A positive correlation existed between E 2 and SHBG levels in both the follicular and luteal phases. The mean plasma SHBG concentration and E 2 /T ratio were significantly higher, while the level of T and the free androgen index were significantly lower, in the luteal phase of women who conceived than in those who did not conceive following COH. The changes of follicular fluid SHBG level and E 2 /T ratio were similar to those in plasma. We concluded, therefore, that increases in SHBG in the follicular and luteal phases may be a reflection of the functional state of ovarian stimulation, and further that such elevations may influence the pregnancy outcome through the modulation of circulating estrogen and androgen balance during down-regulated COH cycles for IVF/ICSI.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Relationship between Sex Hormone-Binding Globulin and Pregnancy Outcome in Women Undergoing Controlled Ovarian Hyperstimulation for Assisted Reproduction

Lin

Sun

2005

Endocr J

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“…However, Odlind et at. 26 have observed that there are no cyclical changes in plasma SHBG during the normal menstrual cycle and that extraordinarily high oestradiol levels (150Q-..40(){} pmollL) were required to increase plasma SHBG levels. Clomiphene citrate, an anti-oestrogen, results in a moderate increase in plasma SHBG in men, although this may be mediated by increased plasma oestradiolY Other reported effects of hormones on plasma SHBG levels include elevation of levels following administration of tri-iodothyroninel'' and suppression of elevated SHBG levels by high doses of glucocorticoids in patients with chronic iasthmatic bronchitis?…”

Section: Discussionmentioning

confidence: 99%

“…and only a markedly elevated level of oestradiol is associated with increased SHBG levels. 26 Therefore, suppressed SHBG levels in obese amenorrhoeic women may be attributable to increased levels of free testosterone, but additional influences cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Sex Steroids and Sex-Hormone-Binding Globulin in Plasma in Physiological and Pathological Conditions

et al. 1985

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SUMMARY. Physiological and many pathological changes in plasma sex-hormonebinding globulin (SHBG) levels have been attributed to the opposing effects of androgens which lower, and oestrogens which elevate, levels. We examined four clinical situations in which changes in SHBG levels may not be explained by sex steroid alterations. (1) Dexamethasone caused an increase in SHBG levels in hyperandrogenaemic hirsute women whether or not androgens were suppressed. (2) In male patients with untreated isolated gonadotrophin deficiency there was a highly significant correlation between SHBG levels and age, but there was no relationship between the levels of SHBG and those of plasma testosterone, androstenedione or DHEAS. (3) Two 46-XY siblings, phenotypic female subjects with complete androgen insensitivity, demonstrated a marked decline in SHBG levels between the ages of 9-13 and 12-16 years. (4) SHBG was suppressed in obese oligomenorrhoeic women while plasma concentrations of testosterone, androstenedione and oestradiol were normal and that of oestrone was elevated; however, the testosterone:SHBG ratio, an index of free testosterone, was elevated. These observations indicate that the decline in SHBG levels which normally occurs in men during the second decade of life is independent of androgen activity and is under the influence of as yet unidentified factors. Glucocorticoids in small doses increase SHBG levels independently of sex steroid alterations while elevated free testosterone concentration may contribute to suppression of SHBG in obesity.More than 98% of circulating testosterone and oestradiol are bound to plasma proteins; the free fraction of these steroids, which is widely believed to be the biologically active component, is thus only 1-2% of the total plasma concentration.l" Sex-hormone-binding globulin (SHBG) binds testosterone, dihydrotestosterone and oestradiol reversibly and with high affinity, I, 5 and is the predominant binding protein in plasma for testosterone and probably also for oestradiol. 3 The concentration of SHBG in plasma influences the proportion of testosterone and oestradiol which is nonprotein-bound or free.

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Effects of prednisolone on sex hormone binding globulin during primary endocrine treatment of advanced breast cancer

Wang

Rubens

Clark

et al. 1988

Breast Cancer Res Tr

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Serum sex hormone binding globulin (SHBG) was measured in 21 pre and 39 postmenopausal women with advanced breast cancer before treatment and 1, 3, 6, 9 and 12 months after ovarian irradiation or during continuous administration of tamoxifen at a dose of 10 mg twice daily, respectively; some patients received additional prednisolone at a dose of 5 mg twice a day. Ovarian irradiation was associated with a 25% reduction in serum SHBG levels 3 to 6 months after treatment whilst patients on tamoxifen experienced a rise of about 80% in serum SHBG levels after 1 to 3 months. In postmenopausal women prednisolone markedly dampened the effect of tamoxifen, reducing a 80% rise to about 20%. There was no relationship between SHBG levels and response to treatment.

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Effects of oestradiol on sex hormone binding globulin

Cited by 54 publications

References 9 publications

Relationship between Sex Hormone-Binding Globulin and Pregnancy Outcome in Women Undergoing Controlled Ovarian Hyperstimulation for Assisted Reproduction

Relationship between Sex Hormone-Binding Globulin and Pregnancy Outcome in Women Undergoing Controlled Ovarian Hyperstimulation for Assisted Reproduction

The Relationship between Sex Steroids and Sex-Hormone-Binding Globulin in Plasma in Physiological and Pathological Conditions

Effects of prednisolone on sex hormone binding globulin during primary endocrine treatment of advanced breast cancer

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