Effects of octreotide on jejunal hypersensitivity triggered by Cryptosporidium parvum intestinal infection in an immunocompetent suckling rat model

Bai, Jie; Khaldi, Samira; Gargala, Gilles; Baishanbo, A.; Audigier, François; Ballet, J.; Ducrotté, Philippe; Fioramonti, Jean; Favennec, Loïc; Goff, Laëtitia Le

doi:10.1111/j.1365-2982.2011.01680.x

Cited by 9 publications

(5 citation statements)

References 79 publications

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“…Newborn rats infected by Cp displayed jejunal hypersensitivity to jejunal distension 120 days post-infection which was associated with increase in activated mast cells. 88, 89 Treatment with octreotide, 10 days post-infection, normalized visceral hypersensitivity, immune cells numbers and changes in the structure of the enteric nervous system. 89 No changes in intestinal motility or permeability in the post-infection stage were reported in this model.…”

Section: Animal Modelsmentioning

confidence: 99%

Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome

et al. 2019

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Background & Aims The existence of post-infection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence has not been well summarized and there is little guidance for diagnosis and treatment of PI-IBS. The ROME Foundation has produced a working team report was to summarize the available evidence on the pathophysiology of PI-IBS and provide guidance for diagnosis and treatment, based upon findings reported in the literature and clinical experience. Methods The working team conducted an evidence-based review of publication databases for articles describing the clinical features (diagnosis), pathophysiology (intestinal sensorimotor function, microbiota, immune dysregulation, barrier dysfunction, enteroendocrine pathways and genetics), and animal models of PI-IBS. We used a Delphi-based consensus system to create guidelines for management of PI-IBS and a developed treatment algorithm based on published findings and experiences of team members. Results PI-IBS develops in about 10% of patients with infectious enteritis. Risk factors include female sex, younger age, psychological distress during or prior to acute gastroenteritis, and severity of the acute episode. The pathogenesis of PI-PBS appears to involve changes in the intestinal microbiome as well as epithelial, serotonergic, and immune system factors. However, these mechanisms are incompletely understood. There is no evidence- based effective pharmacologic strategies for treatment of PI-IBS. We provide a consensus-based treatment algorithm, based on clinical presentation and potential disease mechanisms. Conclusions Based on a systematic review of the literature and team experience, we summarize the clinical features, pathophysiology (from animal models and human studies), and progression of PI-IBS. Based on these findings, we present an algorithm for diagnosis and treatment of PI-IBS based upon team consensus. We also propose areas for investigations.

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Section: Animal Modelsmentioning

confidence: 99%

Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome

et al. 2019

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“…29 Recently, an immunecompetent suckling rat model was established. 1,22 In these studies, C. parvum infections were able to induce digestive hypersensitivity (a key pathophysiological factor in functional digestive disorders, such as irritable bowel syndrome), and the intestinal hypersensitivity was closely associated with intestinally activated mast cell accumulation. To date, there are no reports of the role of mast cells during C. parvum infection in cattle.…”

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confidence: 99%

Infection of Cattle With Cryptosporidium parvum

Yang

et al. 2013

Vet Pathol

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Mast cells might play an important role as the major effector cells in the immune response against Cryptosporidium parvum. C. parvum is a protozoan parasite that causes cryptosporidiosis in animals and humans worldwide. To investigate the interaction between C. parvum and mast cells during infection, nine 3-day-old male calves were orally challenged with 10 6 oocysts of C. parvum per calf. The distribution of mast cells in the mucosa of the small intestine was analyzed by toluidine blue staining. The concentrations of histamine and the cytokines interferon-g, interleukin-4, interleukin-2, and interleukin-12 were measured in the serum, and the histamine levels were also determined from the intestinal contents. The following clinical signs were monitored: nausea, watery diarrhea, dehydration, and weight loss. Oocysts were shed in the feces during the infection period. C. parvum infection induced an increase in mast cell numbers in the mucosa of the small intestine in distinct temporal and spatial patterns. Infection with C. parvum can induce mastocytosis in the entire small intestinal mucosa in immune-competent calves, and the presence of the parasites influences the distribution profile of the mast cells.

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“…The severity of infection and the onset of jejunal hypersensition are different which indicated that they are isolate dependent. Besides, Bai et al [44] also confirmed this model's reliability and found that the agonist of somatostatin could prevent the development of jejunal hypersensitivity in cryptosporidiosis. Trichinella spiralis (T. spiralis) is also a commonly used parasite to establish the PI-IBS model.…”

Section: Parasite Infection Induced Animal Modelmentioning

confidence: 83%