Effects of octamethylcyclotetrasiloxane (D4) on the luteinizing hormone (LH) surge and levels of various reproductive hormones in female Sprague–Dawley rats

Quinn, Anne L.; Dalu, Abe; Meeker, Linda S.; Jean, Paul A.; Meeks, Robert G.; Crissman, James W.; Gallavan, Robert H.; Plotzke, Kathleen P.

doi:10.1016/j.reprotox.2007.02.005

Cited by 62 publications

(20 citation statements)

References 24 publications

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“…Cyclic siloxanes are mostly found in fuel additives, personal care products, and biomedical devices. Limited evidence suggests that cyclic siloxanes may be toxic for laboratory animals and can impair fertility and reproduction 39 – 42 . Our study is the first report of an association between cyclic siloxanes and sIUGR.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue

Wang

Han

Luo

et al. 2018

Sci Rep

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The selective intrauterine growth restriction (sIUGR) of monochorionic diamniotic (MCDC) twins causes phenotypic growth discordance, which is correlated with metabolomic pertubations. A global, untargeted identification of the metabolic fingerprint may help elucidate the etiology of sIUGR. Umbilical cord blood and placentas collected from 15 pairs of sIUGR monochorionic twins, 24 pairs of uncomplicated twins, and 14 singletons diagnosed with intrauterine growth restriction (IUGR) were subjected to gas chromatography-mass spectrometry based metabolomic analyses. Supervised multivariate regression analysis and pathway analysis were performed to compare control twins with sIUGR twins. A generalized estimating equation (GEE) model was utilized to explore metabolic differences within sIUGR co-twins. Linear logistic regression was applied to screen metabolites that significantly differed in concentration between control twins and sIUGR twins or IUGR singletons. Umbilical cord blood demonstrated better global metabolomic separation of sIUGR and control twins compared to the placenta. Disrupted amino acid and fatty acid metabolism as well as high levels of exposure to environmental xenobiotics were associated with sIUGR. The metabolic abnormalities in MCDA twins suggested that in utero growth discordance is caused by intrauterine and extrauterine environmental factors, rather than genetics. Thus, this study provides new therapeutic targets and strategies for sIUGR management and prevention.

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Section: Discussionmentioning

confidence: 99%

Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue

Wang

Han

Luo

et al. 2018

Sci Rep

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“…When administered to rats (0, 700, or 900 ppm) by whole-body vapor inhalation (and presumably dermal absorption) six hours per day over an estrous cycle, there was a complete suppression of the surge in 70% of the females given the higher dose (Quinn et al, 2007). When administered to rats (0, 700, or 900 ppm) by whole-body vapor inhalation (and presumably dermal absorption) six hours per day over an estrous cycle, there was a complete suppression of the surge in 70% of the females given the higher dose (Quinn et al, 2007).…”

Section: Impact Of Toxicants On Mechanisms Of Gnrh Secretionmentioning

confidence: 99%

Endocrine Toxicology

2016

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“…The greatest number of data have been published on the toxicity of D4, which puts people at risk primarily due to the use of cosmetic products. It is considered to have toxic effects on reproductive processes [38][39][40][41], as well as the liver and lungs [42]. The effect of D4 on the estrous cycle of rats and mice also has been found [18,43,44].…”

Section: Effects Of Silicones and Siloxanes On Living Organismsmentioning

confidence: 99%