Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men

Luderer, Ulrike; Bushley, Abigail W.; Stover, Bert; Bremner, William J.; Faustman, Elaine M.; Takaro, Timothy; Checkoway, Harvey; Brodkin, Carl A.

doi:10.1002/ajim.20100

Cited by 23 publications

(4 citation statements)

References 46 publications

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“…[2][3][4] Increased BMI may also be associated with low testosterone and sex hormonebinding globulin or alterations in luteinizing hormone. 4,5,[15][16][17] Other studies have found that weight loss in men can change hormone levels. 16,18 It is also possible that high BMI is associated with higher scrotal temperatures, and this can have adverse effects on spermatogenesis.…”

Section: Discussionmentioning

confidence: 96%

Reduced Fertility Among Overweight and Obese Men

Sallmén¹,

Sandler²,

Hoppin³

et al. 2006

Epidemiology

316

177

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Section: Discussionmentioning

confidence: 96%

Reduced Fertility Among Overweight and Obese Men

Sallmén¹,

Sandler²,

Hoppin³

et al. 2006

Epidemiology

316

177

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“…Further questions asked about exposure to organic solvents or paint, welding or torch-cutting or working with the hull and lead. These types of exposure were considered because of the possible effects on reproductive health [24][25][26][27][28]. Each of these six work exposure items was asked separately for exposure in the Navy and for exposure at other workplaces or at leisure.…”

Section: Questionnairesmentioning

confidence: 99%

Radiofrequency electromagnetic fields; male infertility and sex ratio of offspring

2008

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Concern is growing about exposure to electromagnetic fields and male reproductive health. The authors performed a cross-sectional study among military men employed in the Royal Norwegian Navy, including information about work close to equipment emitting radiofrequency electromagnetic fields, one-year infertility, children and sex of the offspring. Among 10,497 respondents, 22% had worked close to high-frequency aerials to a "high" or "very high" degree. Infertility increased significantly along with increasing self-reported exposure to radiofrequency electromagnetic fields. In a logistic regression, odds ratio (OR) for infertility among those who had worked closer than 10 m from high-frequency aerials to a "very high" degree relative to those who reported no work near high-frequency aerials was 1.86 (95% confidence interval (CI): 1.46-2.37), adjusted for age, smoking habits, alcohol consumption and exposure to organic solvents, welding and lead. Similar adjusted OR for those exposed to a "high", "some" and "low" degree were 1.93 (95% CI: 1.55-2.40), 1.52 (95% CI: 1.25-1.84), and 1.39 (95% CI: 1.15-1.68), respectively. In all age groups there were significant linear trends with higher prevalence of involuntary childlessness with higher self-reported exposure to radiofrequency fields. However, the degree of exposure to radiofrequency radiation and the number of children were not associated. For self-reported exposure both to high-frequency aerials and communication equipment there were significant linear trends with lower ratio of boys to girls at birth when the father reported a higher degree of radiofrequency electromagnetic exposure.

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“…There are many kinds of organic solvents, and different organic solvents affect them through diverse ways. Benzene has been demonstrated in mice testicular atrophy, oligospermia and sperm deformity, sex hormone levels decreased by [17] . Endocrine disrupting chemicals.…”

Section: Common Physical Chemical Natural Environmentmentioning

confidence: 99%

The influence of environmental factors on male fertility and its research progress

Li¹,

Li²

2017

Proceedings of the 2017 3rd International Conference on Economics, Social Science, Arts, Education and Management Engineering (

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Abstract. Male fertility in recent years decreased rapidly, people gradually pay more attention to environmental factors, which is one of the important reasons, in order to explore and analyze the different effects of environmental factors on male fertility, of all kinds of factors, suggesting that people try to avoid damaging the environment function, pay attention to protect their fertility, prevent or slow down the process of male fertility decline. By analyzing various environmental factors leading to the decrease of male fertility, it is concluded that the reduction of male fertility is due to the combined effects of many factors, among which environmental pollution is the most important factor.There are numerous factors that lead to male infertility, including congenital or acquired urogenital malformations, urogenital infections, endocrine disorders, genetic diseases, immunological factors, and environmental factors. But there are still 30% -40% of patients with unknown cause of disease [1]. The decline of human fertility is a gradual process. As people go deep into the study, they gradually give attention to the influence of environment on fertility. Effects of alcohol and tobacco on male fertilityEffects of cigarette smoking on male fertility. There are about 37% [2] of the men of childbearing age smoking, smoking people in our country, the number of about 350 million, suffering from the hazards of passive smoking as high as 540 million numbers [3] . Testicular function is vulnerable to harmful substances in cigarettes, including the sperm DNA integrity and semen quality and sexual function, smoking increases ROS, resulting in oxidative stress, damage sperm function, there is evidence for a genetic and epigenetic Table [4] shows that smoking can eventually lead to male infertility.Influences of alcohol consumption on male fertility. Drinking will also affect male fertility, the regulating effects of neuroendocrine gonadal axis, through direct effects on testis spermatogenic and hormone produced in the environment affected by the effects on sperm quality led to a decline in the number of hormone levels decreased by [5] . Studies have shown that the incidence of [6] male infertility is associated with heavy drinking, and alcohol consumption may be one of the principal causes of male infertility. Common physical, chemical, natural environmentRadiations. Thermal radiation. Spermatogenesis is highly sensitive to temperature changes, and the temperature of the scrotum increases by 1-2 DEG C, which inhibits sperm production by [7]. High temperature (> 36 C) inhibited the proliferation of Sertoli cells, integrity between Sertoli cells by high value-added and value-added cells or his contact between cells, reduce the male fertility of [8], leading to sperm maturity is not enough, affect the survival rate of sperm.Cold conditions also have an impact on them. A study of therapy shows that [9] low temperatures can cause Leydig cells and Sertoli cells to undergo proliferation, and a large number of B type spermatogo...

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Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men

Abstract: The significant associations between FSH levels and solvent exposure indices suggest the potential for adverse effects of solvent exposures on reproductive function in men.

Cited by 23 publications

References 46 publications

Reduced Fertility Among Overweight and Obese Men

Reduced Fertility Among Overweight and Obese Men

Radiofrequency electromagnetic fields; male infertility and sex ratio of offspring

The influence of environmental factors on male fertility and its research progress

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