Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population

Wang, Tao; Ma, Xiaojing; Peng, Danhong; Zhang, Rong; Sun, Xue; Chen, Miao; Yan, Jun; Wang, Shiyun; Yan, Dandan; He, Zhen; Jiang, Feng; Bao, Yuqian; Hu, Cheng; Jia, Weiping

doi:10.1038/srep20691

Cited by 56 publications

(52 citation statements)

References 42 publications

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“…The genetic contribution to obesity explains up to 84% of body mass index (BMI) [4]. Many genes have been implicated in obesity development by several genomewide association studies [17][18][19]. Indeed, currently, at least 190 gene loci have been found to be associated with general obesity and fat distribution [20].…”

Section: Introductionmentioning

confidence: 99%

Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity‐Related Genes

Hammad

Jones

2017

Lipids

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The prevalence of obesity is skyrocketing worldwide. The scientific evidence has associated obesity risk with many independent factors including the quality of dietary fat and genetics. Dietary fat exists as the main focus of dietary guidelines targeting obesity reduction. To prevent/minimize the adipogenic effect of dietary fatty acids (FA), intakes of long-chain saturated- and trans-FA should be reduced and substituted with unsaturated FA. The optimal proportions of dietary unsaturated FA are yet to be defined, along with a particular emphasis on the need to achieve a balanced ratio of n-3:n-6 polyunsaturated FA and to increase monounsaturated FA consumption at the expense of saturated FA. However, inter-individual variability in weight loss in response to a dietary intervention is evident, which highlights the importance of exploring gene-nutrient interactions that can further modulate the risk for obesity development. The quality of dietary fat was found to modulate obesity development by interacting with genes involved in fatty acid metabolism, adipogenesis, and the endocannabinoid system. This review summarizes the current knowledge on the effect of the quality of dietary fat on obesity phenotype and obesity-related genes. The evidence is not only supporting the modulatory effect of fat quality on obesity development but also presenting a number of interactions between obesity-related genes and the quality of dietary fat. The identified gene-FA interaction may have a clinical importance and holds a promise for the possibility of using genetically targeted dietary interventions to reduce obesity risk in the future.

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Section: Introductionmentioning

confidence: 99%

Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity‐Related Genes

Hammad

Jones

2017

Lipids

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“…Control of food intake involves a biochemical process that determines hunger and satiety including the determination of the type of food tastes, appetite, and food frequency. Large and [13].…”

Section: Discussionmentioning

confidence: 99%

“…α-MSH will bind to the receptor and give the effect satiety. Mutations of genes encoding leptin (leptin, POMC, and melanocortin 4 receptor), and signal transduction (signal hunger and satiety) will affect the control of food intake and lead to the onset of obesity [13]. Fig.…”

Section: Discussionmentioning

confidence: 99%

Antiobesity of Fractions Water Extract of Tamarind (Tamarindus Indica L.) in Male Wistar Rats Induced High Carbohydrate Diet

hidayah

Adnyana

Fisheri

et al. 2018

Asian J Pharm Clin Res

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Objective: The prevalence of obesity increases each year globally. Multifactorial etiology of obesity requires therapy management including changing of diet and medicines. Some of obesity drugs have shown ineffectiveness and safety. The previous study showed that water extract of tamarind could reduce body weight (bw). This study aimed to test the activity fraction of water extract tamarind as antiobesity using high carbohydrate diet. Method:The preventive research of antiobesity had done by given water fraction and ethyl acetate fraction of water extract tamarind following with induced high carbohydrate diet during 6 th weeks in male Wistar rats. The parameters had observed including consumption of food, body weight, weight of feces, volume of urine, total cholesterols, triglycerides, blood glucose, index of organs, and accumulation of body fat. Result:The ethyl acetate fraction at doses 4.5 mg/kg bw has shown significantly effect to decrease of total cholesterols level and decrease of triglycerides level at weeks 6 (p<0.05). All the tests of fraction have shown activity inhibition of increased body weight, decrease of appetite, total cholesterols, triglycerides, and blood glucose. Meanwhile, mechanism action of antiobesity as increase defecation, urination, and decrease index of organs and accumulation of body fat have not shown by all these test fractions. Conclusion:The ethyl acetate fraction at doses of 4.5 mg/kg bw can inhibit raising of body weight, decrease of total cholesterols, and triglycerides level greater than the other test groups, where increasing of these levels of blood biochemistry was closely related to the pathology of obesity.

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“…4). Genetic variants in ALDH2 exhibit association with visceral fat accumulation in male 51 and hypertension 52 , both mediated by alcohol consumption, and lead to lower gene expression levels in adipose tissue. Increased visceral adipose tissue (VAT) is a risk factor for carotid artery atherosclerosis, atrial fibrillation and stroke, and low VAT proportion associates with better outcomes in acute ischemic stroke patients 53 .…”

Section: Differential Expression Analysis Of Other Tissuesmentioning

confidence: 99%

Analysis of multi-tissue transcriptomes reveals candidate genes and pathways influenced by cerebrovascular diseases

Pan¹,

Chen²

2019

Preprint

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Cerebrovascular diseases (CVD) are a group of medical conditions that impair circulation of blood to the brain, including stroke, transient ischemic attack (TIA), embolism, aneurysm, and other circulatory disorders affecting the brain. Here, we investigated the effects of having CVD history on the molecular signature of brain regions by comparing gene expression profiles from several brain tissues between cohorts with and without CVD history. We first merged tissue samples from GTEx RNA-Seq dataset into clusters based on the overall gene expression similarity. Then we performed differential expression (DE) analyses for each cluster using a linear mixed model that controls covariates and the individual random effect. Cross-region DE genes were ranked by the combined q-values derived from the mixed model using Fisher's method. Functional enrichment analyses were performed using Gene Set Enrichment Analysis (GSEA) program. We identified hundreds of DE genes, and many of them are related to endothelial or brain functions and associated diseases. We found that STAB1 was highly overexpressed across brain regions in the CVD cohort, and the upregulation of STAB1 in brain tissues may contribute to weaker selfdefense mechanisms against lesions in the brain. Our results suggest a list of candidate genes and pathways that may be dysregulated in the brains of people with CVD history, implying that suffering from CVD could pose potential hazard to the brain.

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Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population

Cited by 56 publications

References 42 publications

Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity‐Related Genes

Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity‐Related Genes

Antiobesity of Fractions Water Extract of Tamarind (Tamarindus Indica L.) in Male Wistar Rats Induced High Carbohydrate Diet

Analysis of multi-tissue transcriptomes reveals candidate genes and pathways influenced by cerebrovascular diseases

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