Effects of nystatin, fluconazole and propolis on poly(methyl methacrylate) resin surface

Silva, Wander José da; Rached, Rodrigo Nunes; Rosalen, Pedro Luis; Cury, Altair Antoninha Del Bel

doi:10.1590/s0103-64402008000300003

Cited by 20 publications

(23 citation statements)

References 19 publications

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“…Silva et al evaluated the effects of 10% EEP on acrylic resin surfaces, and reported an increase in the hardness of resin accumulating on the surface. They proposed that this could act as a barrier for adhesion of Candida species (7).…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the most commonly used concentration of propolis (10% EEP) was selected for testing (7,25,26), and its effectiveness was found to be limited when compared to the other chemical disinfectants.…”

Section: Discussionmentioning

confidence: 99%

“…It has been stated that microbial adherence of C. albicans to the PMMA surface may be attributed to non-specific interactions (electrostatic or hydrophobic interactions) initially, followed by subsequent specific interactions (receptor ligand binding) (6,7). Although some studies have suggested that the adhesion ability of yeasts to polymeric surfaces is modulated by hydrophobic forces, others found no correlation between hydrophobicity and Candida adhesion (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, chemical solutions are not recommended for daily prosthesis disinfection, and natural products have become increasingly popular as an alternative for the prevention of oral diseases. Of these, Propolis, which is a resin extracted from plants by bees (7,24), is considered to be the most promising option. Its various biological activities and therapeutic properties have recently become the focus of research (25), with several studies reporting the inhibitory effects of ethanol extract of propolis (EEP) on Candida species (7,(24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

“…Of these, Propolis, which is a resin extracted from plants by bees (7,24), is considered to be the most promising option. Its various biological activities and therapeutic properties have recently become the focus of research (25), with several studies reporting the inhibitory effects of ethanol extract of propolis (EEP) on Candida species (7,(24)(25)(26). Santos et al stated that 10% EEP was as effective as nystatin in the treatment of patients with denture stomatitis (26).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effectiveness of disinfectants on the adherence of <i>Candida albicans</i> to denture base resins with different surface textures

Karakış¹,

Akay

Oncul³

et al. 2016

J Oral Sci

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Abstract:The aim of the present study was to compare the effects of some disinfectants, including ethanol extract of propolis (EEP), on the adhesion of Candida albicans to denture base resins. Seventy-two acrylic resin samples were prepared, half of which was polished and the other half was roughened. C. albicans strain ATCC 10231 was incubated on Sabouraud dextrose agar (SDA) at 37°C for 48 h. The adhesion period was completed by keeping the cells in this suspension for 90 min at 37°C. Specimens were then immersed in the following solutions: 1%, 2%, and 5% sodium hypochlorite; 4% chlorhexidine gluconate; and 10% EEP. Quantification of the antifungal activity of the chemical solutions was performed using the colorimetric MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay test. One-way ANOVA and post-hoc Tukey tests were performed to evaluate the effectiveness of chemical agents. Polished and roughened surfaces were compared using independent sample t-test. The mean surface roughness value was 0.35 (±0.04) µm for the polished group and 1.2 (±0.2) µm for the roughened group. The contact angles of both surfaces showed statistically significant difference, and 10% EEP solution exhibited significantly less removal of adherent viable C. albicans cells in both groups. All forms of sodium hypochlorite solutions yielded higher efficiency than 4% chlorhexidine gluconate and EEP solutions (P < 0.05). (J Oral Sci 58, 431-437, 2016)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effectiveness of disinfectants on the adherence of <i>Candida albicans</i> to denture base resins with different surface textures

Karakış¹,

Akay

Oncul³

et al. 2016

J Oral Sci

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Bioactivity and architecture of Candida albicans biofilms developed on poly(methyl methacrylate) resin surface

et al. 2010

Self Cite

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The aim of this study was to evaluate the bioactivity and architecture of Candida albicans biofilms developed on the surface of poly(methyl methacrylate) (PMMA) resin. To do this, surface roughness (SR) and surface free energy of PMMA specimens were measured. Next, the biofilms of two different C. albicans strains (ATCC 90028 and SC5314) were allowed to develop on the PMMA surface and evaluated at 24, 48, and 72 h after adhesion. The bioactivity of the biofilms was measured by the XTT reduction assay. Biofilm topography was evaluated by scanning electron microscopy. Confocal microscopy was used to evaluate the architectural properties of bio-volume, average thickness, biofilm roughness, surface area/volume ratio and the proportion of live/dead cells in the different biofilm development stages. SR and SFE had no influence on biofilm development. Each strain exhibited a different biofilm activity (P < 0.001). Confocal images showed different architectures for the different biofilm development stages. We conclude that the main differences detected in biofilm bioactivity and architecture were related to the characteristics of each C. albicans strain and to biofilm development time.

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One‐pot synthesis of a new antifungal polymerisable monomer and its characterisation by coordination‐ion spray mass spectrometry

Zerbib

Amigoni

Givenchy

et al. 2011

Rapid Comm Mass Spectrometry

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We have investigated the synthesis of a new antifungal agent with a polymerisable moiety for the prevention of denture stomatisis. Nystatin (antifungal polyene) is modified in one step by reaction with isocyanatoethylmethacrylate to afford a new polymerisable antifungal agent in good yield (90%). In order to prove the monografting of the acrylate derivative and to localise the new group in the skeleton of the molecule, a rapid and efficient analytical method involving electrospray ionisation mass spectrometry (ESI-MS) was developed for the study. In view of the structures of such antifungal agents, their complexation with metal cations was investigated by Coordination-Ion Spray Mass Spectrometry (CIS-MS). This mass spectrometry study covers two aspects: improving the MS signal to overcome the low ionisation efficiency in ESI-MS and exploring the complexation behaviour of the induced structure to optimise the antifungal properties.

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Effects of nystatin, fluconazole and propolis on poly(methyl methacrylate) resin surface

Cited by 20 publications

References 19 publications

Effectiveness of disinfectants on the adherence of <i>Candida albicans</i> to denture base resins with different surface textures

Effectiveness of disinfectants on the adherence of <i>Candida albicans</i> to denture base resins with different surface textures

Bioactivity and architecture of Candida albicans biofilms developed on poly(methyl methacrylate) resin surface

One‐pot synthesis of a new antifungal polymerisable monomer and its characterisation by coordination‐ion spray mass spectrometry

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