Effects of Nyctanthes Arbor-Tristis and Colchicine on the Growth of Uric Acid Crystals

Saul, Sugantha

doi:10.5958/2231-5675.2017.00014.x

Asian Jour. Pharmac. Anal.

2017

DOI: 10.5958/2231-5675.2017.00014.x

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Effects of Nyctanthes Arbor-Tristis and Colchicine on the Growth of Uric Acid Crystals

Sugantha Saul¹

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Investigation of Aspartame effects on some blood parameters after oral administration in Balb-c mice

Alkhalil

Yasein

2021

RJPT

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No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake. Aspartame is a methyl ester of a dipeptide used as a synthetic nonnutritive sweetener in over 90 countries worldwide in over 6000 products. It was first approved by the US Food and Drug Administration (FDA) in 1981. Aspartame is metabolized to phenylalanine, aspartic acid, and methanol. these metabolites have some health risks specially on PKU (Phenyl Ketone Urea) patients who can’t metabolize the amino acid phenyl alanine. This study aims to investigate the health effects of aspartame on Balb-c mice. 16 Balb-c mice were given physiological solution by oral gavage(control) and the study groups were given the recommended ADI (Acceptable Daily Intake) for mice (ADI = 250mg/kg/body weight) of Aspartame diluted in water for 15days, 30days. Glucose blood level, lipid profile, marker enzymes (ALT.AST.ALP, γGT) and uric acid were determined at the end of the experiment. The results of this study show that oral administration of aspartame (250mg/kg body weight) was correlated to a significant increase in the lipid profile, fasting blood glucose and some marker enzymes and this increase is time related.

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Investigation of Aspartame effects on some blood parameters after oral administration in Balb-c mice

Alkhalil

Yasein

2021

RJPT

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Total Phenolic content and Potential of Black Betel Leaf (Piper betle L.var Nigra) Extract as an Antioxidant and Anti-Gout

Irawan,

Rochaeni,

Suhartini

et al. 2024

RJPT

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Research to find antioxidants and anti-gout has been done using black betel leaf. The sample was extracted at room temperature for 30 minutes using the Ultrasound-Assisted Extraction (UAE) method, and a yield of 8.47% was obtained. Phytochemical screening was carried out on the ethanol extract of black betel leaves and showed the presence of secondary metabolite compounds consisting of alkaloids, phenolics, saponins, tannins, and steroid glycosides, with a total phenolic content of 758,534±0.003mg GAE per gram of sample. Antioxidant activity analysis was carried out using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) methods, which showed IC50 and EC50 values of 115.562±0.14mg/L and 119.273±0.385 mg/L, respectively. The antioxidant activity of black betel leaf extract is in the medium category (100–150 mg/L). The anti-gout activity test was carried out using allopurinol as a control, which showed the ability of black betel leaf extract to reduce uric acid up to 14.48±0.01%. The ability of black betel leaf extract as an anti-uric acid is five times better than allopurinol, which is commonly used as a gout drug. The research results obtained opened up the opportunity to find a natural medicine for gout.

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Effects of Nyctanthes Arbor-Tristis and Colchicine on the Growth of Uric Acid Crystals

Cited by 2 publications

References 0 publications

Investigation of Aspartame effects on some blood parameters after oral administration in Balb-c mice

Investigation of Aspartame effects on some blood parameters after oral administration in Balb-c mice

Total Phenolic content and Potential of Black Betel Leaf (Piper betle L.var Nigra) Extract as an Antioxidant and Anti-Gout

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