Effects of Nutritional Supplementation on Prealbumin Concentrations in Pediatric Burn Patients: A Randomized, Controlled Trial

Abstract

Abstract:Introduction: This prospective, randomized study was designed to measure the effect of nutritional supplementation on serum prealbumin (transthyretin) in pediatric burn patients in seven burn centers in Russia. The primary measure was change in serum prealbumin from baseline to Day 7.Methods: Fifty-four children age 1-10 years with a TBSA burn of at least 15% were enrolled into this study. Patients had baseline serum prealbumin levels < 10 mg/dL and were capable of exclusive oral feeding within 72 hours of hospitalization. One-hundred-sixteen children were screened, with 54 meeting eligibility criteria, 28 subjects in the control group and 26 in the supplement group. Patients were randomized to receive the typical hospital diet for mild to moderate burn patients or the same diet plus additional oral nutritional supplementation. The additional enteral supplementation was 299 kcal/day for most of the subjects.Results: Nutritional supplementation significantly increased serum prealbumin levels of the subjects from baseline to Day 7. At Day 7, children consuming the supplementation had a mean ± standard error change in prealbumin concentration of 8.44 ± 1.13 mg/dL and children on hospital diet only had a change of 5.47 ± 0.80 mg/dL, with a difference of 2.97 mg/dL (p=0.0265). There were no significant differences in baseline serum prealbumin concentration, nor were there differences for adverse events or safety concerns related to study product. Conclusions:The increase of prealbumin related to enteral supplementation may provide future guidance for nutritional management of pediatric burn patients or patients with increased energy and protein needs.

Investigating the Effect of Two Methods of Continuous and Bolus Enteral Nutrition on Serum Albumin and Prealbumin levels in Patient with Mechanical Ventilation: A randomized clinical trial

“…A total of 64 patients were assessed in terms of entry criteria, and 7 patients were excluded as they did not meet the entry criteria. Of the 51 patients who were randomly assigned to the intervention group (26) and control (25), 17 participants were excluded from the study due to various reasons; 7 patients due to death, 5 due to intolerance, 3 due to cessation of feeding, and 2 due to changes in the feeding method during the intervention(Figure 1). So, nally 34 participants (17 people in the intervention group (7 men and 10 women) and 17 patients in the control group (9 men and 8 Women) completed the study for a week and were statistically analyzed.…”

“…However, our study is the rst study to compare albumin responses to two methods of continuous feeding and bolus feeding. In a study of burn patients, Williams et al [25] showed that nutritional adequacy can be measured by increasing prealbumin levels. In trauma and burn patients, prealbumin level is the most reliable indicator of nutritional adequacy [25].…”

Comparison of the effects of enteral feeding through the bolus and continuous methods on blood sugar and prealbumin levels in ICU inpatients

“…[ 25 ] In a clinical trial (2011) on burned children in Russia, it was shown that appropriate nutrition was accompanied with an increase in the prealbumin level. [ 15 ] In another study on the ICU patients, a notable increase in the level of patients’ prealbumin level was observed after adequate and appropriate nutrition, compared with the subjects without adequate nutrition. [ 26 ]…”

“…Serial measurements of prealbumin, as a precise monitoring tool, and evaluation of nutrition are applicable to modify the condition. [ 15 ]…”

Factor structure of the Persian version of general, social, and negative self-consciousness of appearance domains of Derriford Appearance Scale 59: an application in the field of burn injuries

“…Approximately 90% of burn injuries occur in low- to middle-income countries 8. Specifically, burn injury has been considered a major health problem in Iran 9…”