Effects of nutritional supplementation combined with low-intensity exercise in malnourished patients with COPD

Sugawara, Keiyu; Takahashi, Hitomi; Kasai, Chikage; Kiyokawa, Noritaka; Watanabe, Tohru; Fujii, Sayaka; Kashiwagura, Takeshi; Honma, Mitsunobu; Satake, Masahiro; Shioya, Takanobu

doi:10.1016/j.rmed.2010.05.008

Cited by 113 publications

(93 citation statements)

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“…A recent study suggested that pulmonary rehabilitation had a positive impact on functional status and quality of life for interstitial lung disease patients including those with IPF [35,36]. In addition, it was proposed that the combination of nutritional support and rehabilitation was beneficial for improving exercise capacity and the quality of life in COPD [37]. Considering this, studies evaluating the efficacy of rehabilitation integrated with nutritional support are expected in the future.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Significance of Body Weight Loss in Idiopathic Pulmonary Fibrosis Patients

et al. 2018

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Background: The significance of the nutritional status in idiopathic pulmonary fibrosis (IPF) is largely unknown. Temporal body weight (BW) change, a dynamic index of nutrition status, can detect the malnutrition more accurately than the conventional single-point body mass index evaluation. Objective: To investigate how the temporal BW change influences the clinical courses of IPF. Methods: This multicenter study enrolled IPF patients from four referral hospitals of interstitial lung diseases in Japan (the Japanese cohort, the derivation cohort) and the Royal Brompton Hospital (the UK cohort, the validation cohort). The annual rate of BW change from the initial presentation was evaluated. A > 5% decrease of BW was defined as a significant BW loss. Results: Twenty-seven out of 124 patients in the Japanese cohort and 13 out of 86 patients in the UK cohort showed significant BW loss. Patients with BW loss showed significantly worse survival in both cohorts. Multivariate analyses revealed that BW loss was an independent factor for decreased survival (Japanese cohort: p = 0.047, UK cohort: p = 0.013). A 6.1% loss of BW was chosen as the optimal cutoff value to predict the 2-year mortality from the initial presentation. The stratified analysis revealed that a 6.1% or greater BW loss could predict worse survival specifically in cases without a greater than 10% decline in forced vital capacity (FVC). Conclusions: BW loss is independently associated with the survival of IPF patients, particularly when a decline in the FVC was not observed. Further studies are needed to understand the mechanisms underlying BW loss in IPF.

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Section: Discussionmentioning

confidence: 99%

The Clinical Significance of Body Weight Loss in Idiopathic Pulmonary Fibrosis Patients

et al. 2018

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“…In two studies, patients in the intervention group were offered nutritional support as part of pulmonary rehabilitation including exercise, while the control group was offered usual care [41,42]. All except one study [44] used oral nutritional supplements (ONS).…”

Section: Data Extraction Synthesis Of Data and Statistical Analysis mentioning

confidence: 99%

Danish evidence-based clinical guideline for use of nutritional support in pulmonary rehabilitation of undernourished patients with stable COPD

Beck

Iepsen

Tobberup

et al. 2015

Clinical Nutrition ESPEN

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“…[14] Another study also indicated an increase in average BMI after 12 weeks of nutrition support. [15] An increase in weight is inferred from BMI changes after the nutrition therapy. The present study showed an increase in average weight, from 51.9 kg to 52.8 kg.…”

Section: Resultsmentioning

confidence: 99%

Effect of Ophiocephalus striatus Extract on the Levels of TNF-α, CRP, Leptin, Adiponectin, and COPD Assessment Test (CAT) Score in Stable COPD Patients with Muscle Wasting

Djajalaksana¹,

Kusumawardhani²,

Rahayu³

2018

Turk J Immunol

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Effects of nutritional supplementation combined with low-intensity exercise in malnourished patients with COPD

Cited by 113 publications

References 41 publications

The Clinical Significance of Body Weight Loss in Idiopathic Pulmonary Fibrosis Patients

The Clinical Significance of Body Weight Loss in Idiopathic Pulmonary Fibrosis Patients

Danish evidence-based clinical guideline for use of nutritional support in pulmonary rehabilitation of undernourished patients with stable COPD

Effect of Ophiocephalus striatus Extract on the Levels of TNF-α, CRP, Leptin, Adiponectin, and COPD Assessment Test (CAT) Score in Stable COPD Patients with Muscle Wasting

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