Effects of nutrition on tumor growth and tolerance to chemotherapy

Steiger, Ezra; Oram-Smith, Jeffrey C.; Miller, Elizabeth E.; Kuo, Lawrence C.; Vars, Harry M.

doi:10.1016/0022-4804(75)90109-2

Cited by 136 publications

(21 citation statements)

References 15 publications

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“…6) nor increase in host body weight (Fig. 7) were observed ; these facts are similar to those reported by Steiger (Steiger et al 1975). These findings imply that tumor growth is not directly related to calorie dosage but rather depends on the kind of amino acids administred.…”

Section: Resultssupporting

confidence: 91%

Anti-cancer therapy with valine-depleted amino acid imbalance solution.

Nishihira

Takagi

Kawarabayashi

et al. 1988

Tohoku J. Exp. Med.

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For the purpose of developing amino acid imbalance solution applicable to cancer treatment, we prepared seven kinds of amino acid imbalance solutions based on a 10% balanced amino acid solution and investigated the anti-tumor effects of each solution. The administration of valine-depleted amino acid solution for 8 days at a daily dose of 53 ml/rat (79.5 kcal/rat) resulted in the most significant inhibitory effects on the growth of hepatoma (AH109A) and mammary tumors (MRMT-1), the rate being 82.8% and 90.8%, respectively. Side effects observed were inhibition of increases in host body weight , weight loss of the spleen and thymus, loss of hair, and a decrease in the amounts of total plasma protein and albumin. When the daily dosage of valine-depleted amino acid solution was reduced to 40 ml/rat (58.3 kcal/rat), anti-tumor effects were still noticed , while side effects were abated. These findings indicate that side effects accompanying the use of this solution can be alleviated by controlling the ingredients of the solution as well as the amount administered. It is thus suggested that valine-depleted amino acid imbalance solution is a valuable tool in the treatment of cancer.amino acid imbalance; valine; isoleucine; total parenteral nutrition Attempts to inhibit tumor growth by the use of amino acid solution from which a certain essential amino acid has been removed (amino acid imbalance solution) have been carried out by many researchers (Drummond 1917;Skipper and Johnson 1958;Sugimura et al. 1959;Lorincz and Kuttner 1965;Theuer 1971) Since the administration of such imbalance solution was carried out orally or through the stomach in these studies, the amount of intake tended to decrease or dosage was inevitably limited, and therefore, it was almost impossible to maintain a good state of nutrition.For this reason, it was quite difficult to determine whether anti-tumor effects obtained were induced by the poor state of

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Section: Resultssupporting

confidence: 91%

Anti-cancer therapy with valine-depleted amino acid imbalance solution.

Nishihira

Takagi

Kawarabayashi

et al. 1988

Tohoku J. Exp. Med.

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“…It has been stated that parenteral nutri tional support may not only benefit the pa tient, since it also increases tumor growth [20]: the rate of tumor growth paralleled that of the host [21], However, even if nutritional repletion does stimulate tumor growth, che motherapeutic agents should be most effec tive when their administration coincides with accelerated tumor cell replication [22,23], No stimulation of tumor growth has been ob served in malnourished patients during short periods of nutritional repletion [24], Altogether, parenteral nutrition appears to somewhat benefit the healing of anastomoses in the intestine constructed during cytostatics administration. It also seems likely that the deleterious effects of cytostatics are lessened, to a certain degree, by intravenous saline alone.…”

Section: Discussionmentioning

confidence: 99%

Cytostatics and Anastomotic Healing in the Intestine: an Experimental Study on the Effect of Parenteral Nutrition

Zuidewijn¹,

Hendriks²,

Wobbes³

et al. 1992

Eur Surg Res

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The effects of parenteral nutrition on the healing of experimental ileal and colonic anastomoses constructed on the 3rd day of a 5-day cytostatics course were investigated. Intravenous saline alone already reduced weight loss induced by cytostatics while parenteral nutrition almost completely prevented postoperative loss of weight. A negative effect of cytostatics on anastomotic bursting strength was found in the ileum 7 days after operation. Parenteral feeding negated this effect but had no positive effect on anastomotic hydroxyproline content. Thus, parenteral nutrition increases the strength of intestinal anastomoses, constructed during a cytostatics regimen, but intravenous saline alone also appears to have a similar effect.

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“…Many chemotherapeutic agents induce anorexia, diarrhea or nausea, and although those effects might decrease nutrient balance, little consideration has been given to the effect of selective chemotherapeutic agents on protein metabolism in experimental studies. In healthy rats treated with daily injection of 5-fluorouracil, N balance decreased after initiation of treatment and became progressively negative [7]. Similarly, a single injection of 4-epidoxorubicin reduced N balance by 55% over a 5-day study in tumor-bearing rats, but not in healthy animals [8].…”

Section: Treated Tumor-bearing Animal Modelsmentioning

confidence: 99%

Animal Models for Nutrition in Cancer

Baracos¹,

Bricon²

2000

Cancer &Amp; Nutrition

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167 Selection of a model is central to the design of an animal study of carcinogenesis and cancer progression or metastasis. Cancer-associated malnutrition and its dietary therapy in animals is the subject of literature which is marked by the lack of a consensus approach to the use of models and dietary design. There is no single ideal animal model and valuable insights are available from a diversity of animal models. Animal models offer a great advantage in terms of standardization of study conditions, and this is countered by the very great difficulty in extrapolation of results to humans in clinical situations. Most of the work to date has addressed nutritional effects on growth of already established tumors. Treatment by chemotherapy or other approaches has not been extensively integrated into nutritional models to date.The reader is referred to an excellent review by Birt [1], which touches upon methodologic issues, theoretical considerations and design criteria for experimental studies of nutrition and cancer. Although written with particular reference to the fat level and composition of the diet, many important considerations for all types of nutritional experimentation in the cancer area are raised, including models of carcinogenesis and transplantable tumors, and considerations for dietary design. This review focuses on a subset of literature reflecting the authors' experience with models of cancer cachexia and negative nitrogen balance, mediators of protein anabolism and catabolism, and amino acid nutrition in cancer.

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Effects of nutrition on tumor growth and tolerance to chemotherapy

Cited by 136 publications

References 15 publications

Anti-cancer therapy with valine-depleted amino acid imbalance solution.

Anti-cancer therapy with valine-depleted amino acid imbalance solution.

Cytostatics and Anastomotic Healing in the Intestine: an Experimental Study on the Effect of Parenteral Nutrition

Animal Models for Nutrition in Cancer

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