Effects of nutrition, growth hormone disturbances, training, altitude and sleep on lung volumes

Gaultier, Claude; Crapo, Robert O.

doi:10.1183/09031936.97.10122913

Cited by 29 publications

(21 citation statements)

References 77 publications

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“…Consistent with previous studies (3,6,7,21,(36)(37)(38)40), we obtained a rather low R 2 and high SEE in the LV prediction, i.e., a substantial percentage of the LV variance could not be explained by the variables analyzed (Table 5). These results are consistent with the traditional notion that LV are far less reproducible than spirometric variables, reinforcing the necessity of using accurate and representative reference values.…”

Section: Discussionsupporting

confidence: 79%

“…Conversely, it is more reasonable to hypothesize that taller, younger and more active subjects present both a higher LV and fitness level. Whether this higher LV could provide an advantage in terms of physical performance has been demonstrated thus far only for competitive athletes and for specific modalities; in sedentary subjects this theoretical handicap seems to be improbable (40).…”

Section: Discussionmentioning

confidence: 99%

“…Another variable which has been linked to LV is the level of physical fitness (40). Although it is accepted that there is no true pulmonary/ventilatory limitation of maximal dynamic exercise, at least in non-athlete subjects at sea level, some studies have shown a moderate relationship between LV and indexes of fitness (41,42).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Reference values for lung function tests: I. Static volumes

Neder

Andreoni

Castelo-Filho

et al. 1999

Braz J Med Biol Res

256

175

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Static lung volume (LV) measurements have a number of clinical and research applications; however, no previous studies have provided reference values for such tests using a healthy sample of the adult Brazilian population. With this as our main purpose, we prospectively evaluated 100 non-smoking subjects (50 males and 50 females), 20 to 80 years old, randomly selected from more than 8,000 individuals. Gender-specific linear prediction equations were developed by multiple regression analysis with total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), RV/TLC ratio and inspiratory capacity (IC) as dependent variables, and with age, height, weight, lean body mass and indexes of physical fitness as independent ones. Simpler demographic and anthropometric variables were as useful as more complex measurements in predicting LV values, independent of gender and age (R 2 values ranging from 0.49 to 0.78, P<0.001). Interestingly, prediction equations from North American and European studies overestimated the LV at low volumes and underestimated them at high volumes (P<0.05). Our results, therefore, provide a more appropriate frame of reference to evaluate the normalcy of static lung volume values in Brazilian males and females aged 20 to 80 years.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Reference values for lung function tests: I. Static volumes

Neder

Andreoni

Castelo-Filho

et al. 1999

Braz J Med Biol Res

256

175

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“…Evidence of the effects of acute exposure to hypoxia on RV and TLC suggests that both increase on initial exposure to altitude but return to baseline after around a month at altitude (12). An increase in RV or a fall in TLC could produce a fall in FVC, but as both these volumes increase they would tend to cancel each other out, making it unlikely that changes in lung volume are a sufficient explanation for the observed impedance changes.…”

Section: Discussionmentioning

confidence: 95%

Serial changes in nasal potential difference and lung electrical impedance tomography at high altitude

Mason¹,

Petersen

Mélot

et al. 2003

Journal of Applied Physiology

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Mason, Nicholas P., Merete Petersen, Christian Mé lot, Bakyt Imanow, Olga Matveykine, Marie-Therese Gautier, Akpay Sarybaev, Almaz Aldashev, Mirsaid M. Mirrakhimov, Brian H. Brown, Andrew D. Leathard, and Robert Naeije. Serial changes in nasal potential difference and lung electrical impedance tomography at high altitude. J Appl Physiol 94: 2043-2050, 2003. First published December 6, 2002 10.1152 10. /japplphysiol.00777.2002 work suggests that treatment with inhaled ␤2-agonists reduces the incidence of high-altitude pulmonary edema in susceptible subjects by increasing respiratory epithelial sodium transport. We estimated respiratory epithelial ion transport by transepithelial nasal potential difference (NPD) measurements in 20 normal male subjects before, during, and after a stay at 3,800 m. NPD hyperpolarized on ascent to 3,800 m (P Ͻ 0.05), but the change in potential difference with superperfusion of amiloride or isoprenaline was unaffected. Vital capacity (VC) fell on ascent to 3,800 m (P Ͻ 0.05), as did the normalized change in electrical impedance (NCI) measured over the right lung parenchyma (P Ͻ 0.05) suggestive of an increase in extravascular lung water. EchoDoppler-estimated pulmonary artery pressure increases were insufficient to cause clinical pulmonary edema. There was a positive correlation between VC and NCI (R 2 ϭ 0.633) and between NPD and both VC and NCI (R 2 ϭ 0.267 and 0.418). These changes suggest that altered respiratory epithelial ion transport might play a role in the development of subclinical pulmonary edema at high altitude in normal subjects. pulmonary edema; hypobaric hypoxia ALTHOUGH ONLY A MINORITY OF those who go to high altitude develop the potentially fatal condition of highaltitude pulmonary edema (HAPE), there is increasing evidence that the majority of people ascending to altitude may develop subclinical pulmonary edema (9). Forced vital capacity (FVC) falls on ascent to high altitude and is thought to be primarily due to subclinical pulmonary edema (32). The control of pulmonary extravascular lung water (EVLW) has traditionally been attributed to the interplay of Starling forces, with the pulmonary capillary pressure attributed the major regulatory role. It is now realized that sodium transport across the respiratory epithelium plays an important role in the removal of alveolar water (34) and that an intact epithelial barrier is necessary for the resolution of alveolar edema (35). Hypoxia reduces epithelial sodium transport in cultured rat alveolar epithelial monolayers (29) and decreases the expression of alveolar epithelial ion transport proteins (8). In addition, treatment of HAPE-susceptible individuals with inhaled ␤ 2 -agonists, which are known to increase transepithelial sodium transport, decreases pulmonary edema without any effect on pulmonary hemodynamics (44).Measurement of alveolar ion transport in vivo in human subjects is not feasible; however, measurement of the potential difference (PD) generated by ion transport in the nasal mucosa can be used as a marker...

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“…Además, se ha encontrado que la ubicación geográfica, la nutrición y la exposición ambiental influyen sobre la función pulmonar (4,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21).…”

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Valores de referencia para parámetros de espirometría en la población adulta residente en Bogotá, D. C., Colombia

Rojas

Dennis

2010

biomedica

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Nombre de la institución donde se llevó a cabo el trabajo:Departamento de Epidemiología Clínica y Bioestadística, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, D.C., ColombiaIntroducción. Los valores de referencia para parámetros de la función pulmonar aplicables a otras poblaciones, han mostrado ser poco válidos en la interpretación de las pruebas de función pulmonar en la población adulta residente en Bogotá. Objetivo. Identificar cuál de cuatro modelos de predicción generados en poblaciones con características étnicas similares a la población colombiana, es el más adecuado para utilizar en adultos de Bogotá. Materiales y métodos. Se reclutaron 534 sujetos de ambos sexos entre los 18 y los 65 años de edad, no fumadores, libres de alteraciones pulmonares, trabajadores de tres empresas privadas y residentes en Bogotá por más de cinco años. La función pulmonar se midió por curva de flujo volumen. Se estimaron las diferencias observadas entre valores predichos y observados, y se calcularon los límites por el método de Bland y Altman. Se aceptaron como válidos los modelos que presentaron un error de predicción promedio máximo de 5% del valor observado en cada parámetro. Resultados. Demostraron ser válidos en esta población los modelos: Crapo para capacidad vital forzada (CVF) en hombres; Pérez-Padilla, para CVF en mujeres y para la relación con el volumen espiratorio forzado en el primer segundo (VEF 1 /CVF) en ambos grupos y los de Hankinson para mexicano-americanos para todos los parámetros en ambos sexos. Conclusiones. Los modelos de Hankinson demostraron ser los más adecuados para predecir todos los parámetros de la espirometría; sin embargo, dejan un porcentaje de mala clasificación promedio de 7%. Se requiere generar modelos propios con mayor precisión pronóstica en la población de Bogotá.Palabras clave: estudios de validación, valores de referencia, pruebas de función respiratoria, modelos lineales, adulto, altitud. Reference values for respiratory parameters in the adult population of Bogotá, D.C., ColombiaIntroduction. Reference values for pulmonary function parameters, generally applicable to most populations, have shown little validity in the correct interpretation of pulmonary function tests when applied to the adult population in Bogotá. Objective. To identify which of four prediction models generated for use in populations of a similar ethnic background to that found in Colombia is the most accurate for use in adults in Bogotá. Materials and methods. 534 subjects (male and female) between 18 and 65 years of age were recruited from a pool of workers employed by three private Bogotá companies. All subjects had resided in Bogotá for at least five years before the initiation of the study. Smokers and those with altered pulmonary function were excluded. Pulmonary function parameters were measured by flow volume curve. The results were analyzed (specifically, the difference between predicted and observed values) and the limits were calculated using the Bland & Altman method. A maximum aver...

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Effects of nutrition, growth hormone disturbances, training, altitude and sleep on lung volumes

Cited by 29 publications

References 77 publications

Reference values for lung function tests: I. Static volumes

Reference values for lung function tests: I. Static volumes

Serial changes in nasal potential difference and lung electrical impedance tomography at high altitude

Valores de referencia para parámetros de espirometría en la población adulta residente en Bogotá, D. C., Colombia

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