Effects of Novel Cuproptosis-related Long Noncoding RNAs on the Prognosis and Immune Microenvironment of Wilms Tumor

Abstract

Purpose Unlike all other known types of regulated cell death, cuproptosis is a unique copper-dependent cell death pathway that is closely connected to mitochondria and metabolism. The pathogenesis of Wilms tumor (WT), a common pediatric abdominal tumor, has yet to be fully elucidated. However, studies on long noncoding RNAs related to cuproptosis in WT and the relationship between Wilms tumor, the microenvironment, and cuproptosis are still scarce. Results Our results showed that among individuals with WT, those included in the high-risk group identified using the signature were demonstrated poor survival outcomes. Moreover, we found that the high-risk group had a worse prognosis (P < 0.001) than the group of low-risk. The area under the curve value for this signature was 0.818, which was higher than that for age (0.524), sex (0.580), race (0.489), stage (0.673), and the modeling of ferroptosis-related lncRNAs (0.775). Individuals in the group of low-risk group had an elevated Tumor Immune Dysfunction and Exclusion scores and were more sensitive to 13 drugs, including BI-2536, EX-527, IspinesibMesylate, and KIN001-135. Conclusion Our model can precisely predict the prognosis of WT patients and differentiate between those at low and high risk. The current study introduces a novel approach for predicting clinical prognosis and determining the appropriate therapy for patients with WT.