Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications

Snitker, Søren; Fujishima, Yoshiyuki; Shen, Haiqing; Ott, Sandy; Pi‐Sunyer, Xavier; Furuhata, Yasufumi; Sato, Hitoshi; Takahashi, Michio

doi:10.3945/ajcn.2008.26561

Cited by 239 publications

(196 citation statements)

References 28 publications

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“…They were ineffective in reducing body fat in a 6-week study [87], but reduced abdominal fat in a 12-week study [89].…”

Section: Cold Capsaicin and Nicotinementioning

confidence: 91%

Horizons in the Pharmacotherapy of Obesity

Arch

2015

Curr Obes Rep

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Abstract:Obesity drugs have had a chequered history. In the recent past, only the low efficacy, pancreatic lipase inhibitor orlistat was available worldwide and it was little used. The 5HT2C agonist lorcaserin, and two combinations of old drugs have been approved in the United States but not in Europe. The diabetes drug liraglutide has been approved in both the US and Europe and seems likely to be most widely accepted. In view of regulators' caution in approving obesity drugs, some (like beloranib) may initially be progressed for niche obesity markets. New drug targets have been identified in brown adipose tissue with the aim of not only activating thermogenesis but also increasing the capacity for thermogenesis in this tissue. Attempts are being made to match the efficacy of bariatric surgery by mimicking multiple gut hormones. Unapproved pharmacotherapies are tempting for some patients. Others remain optimistic about more conventional routes to pharmacotherapy.3

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“…They were ineffective in reducing body fat in a 6-week study [87], but reduced abdominal fat in a 12-week study [89].…”

Section: Cold Capsaicin and Nicotinementioning

confidence: 91%

Horizons in the Pharmacotherapy of Obesity

Arch

2015

Curr Obes Rep

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“…Our group recently (6) reported that a non-pungent capsaicin analog (capsinoids) increases EE through the activation of BAT in humans. Slight but significant fat-reducing effects of capsinoids are also reported in mildly obese human subjects (7)(8)(9). Significantly, the effects of capsaicin and capsinoids are much attenuated in mice lacking the transient receptor potential vanilloid 1 (TRPV1) (10), a capsaicin receptor.…”

mentioning

confidence: 99%

Daily Ingestion of Grains of Paradise (Aframomum melegueta) Extract Increases Whole-Body Energy Expenditure and Decreases Visceral Fat in Humans

Sugita

Yoneshiro

Sugishima

et al. 2014

J Nutr Sci Vitaminol

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The global increase in obesity and associated metabolic disorders underscores the need for effective treatments. In principle, obesity can be treated by reducing energy intake and/or increasing energy expenditure (EE). Some food ingredients have been proposed as tools for increasing EE and decreasing body fat. A prominent example is capsaicin, a pungent principle of hot pepper that activates the adreno-sympathetic nervous system and brown adipose tissue (BAT) thermogenesis, increases EE and fat oxidation, and reduces body fat (1-5). Our group recently (6) reported that a non-pungent capsaicin analog (capsinoids) increases EE through the activation of BAT in humans. Slight but significant fat-reducing effects of capsinoids are also reported in mildly obese human subjects (7-9). Significantly, the effects of capsaicin and capsinoids are much attenuated in mice lacking the transient receptor potential vanilloid 1 (TRPV1) (10), a capsaicin receptor. This suggests that the thermic and fat-reducing effects of capsaicin and capsinoids are elicited by activation of the pathway of TRPV1, the sympathetic nervous system, and BAT.Grains of paradise (Aframomumu melegueta [Rosco] K. Schum.) (GP), also known as Guinea pepper or Alligator pepper, belong to the Zingiberaceae family native to west Africa. GP seeds are used as a spice for food and as an agent for wide-ranging ethnobotanical uses, for example, as a remedy for treating stomachache, diarrhea, and snakebite (11). GP seeds are very rich in nonvolatile pungent compounds such as 6-paradol, 6-gingerol, 6-shogaol and related compounds (12-14). These compounds share an important structural feature with capsaicin, namely, a vanilloid moiety. This feature may equip them with the power to activate the pathway of TRPV1 (15, 16), the sympathetic nervous system, and BAT, and thereby to increase EE. In fact, Iwami et al. found that the intragastric administration of an alcohol extract of GP and 6-paradol to rats enhanced the efferent discharges of sympathetic nerves to BAT and induced a significant rise in BAT temperature (17). In a previous study by our group, a single ingestion of GP extract increased EE through the activation of BAT in men (18). We can thus speculate that a repeated ingestion of GP extract will result in a sustained elevation of EE and a consequent reduction of body fat. In the present study we tested this hypothesis by examining the effects of a daily ingestion of GP extract on EE and body composition, particularly the subcutaneous and visceral fat content, in healthy human volunteers. Daily Ingestion of Grains of Paradise (Aframomum melegueta)Extract Summary We reported previously that a single ingestion of an alcohol extract of grains of paradise (GP, Aframomum melegueta), a species of the ginger family, increases energy expenditure (EE) through the activation of brown adipose tissue, a site of sympathetically mediated metabolic theromogenesis. The present study aimed to examine a daily ingestion of GP extract on whole-body EE and body fat in humans. Whole-b...

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“…One of these natural compounds with similar properties to capsaicin is capsiate. Its supplementation in daily dose of 6 mg for 12 weeks causes decrease of abdominal adipose tissue [59]. Studies on animal experimental model confirmed that administration of 5 ml/kg b.w.…”

Section: Antiobesity Activitymentioning

confidence: 68%

Health-promoting properties of compounds derived from Capsicum sp. A review

Szydełko

Boguszewska-Czubara

2017

Herba Polonica

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S u m m a r yThis article presents multidirectional effects of capsaicin and its natural derivatives as well as natural and synthetic analogs in term of their therapeutic properties. Active agents present in various Capsicum genus plants exert analgesic, anti-inflammatory, antibacterial, antioxidant and gastroprotective effects. Furthermore, capsaicin positively influences the metabolism of lipids. Numerous research show that capsaicinoids inhibit proliferation and migration process of cancer cells, what makes them molecules of high interest in oncology. Among broad range of positive activities, we have focused only on those properties that have already found application in medicine or seemed to be the most probably used in the near future. Even if in low or single doses this compound has been reported successful in numerous therapies, the negative consequences of high doses or prolonged administration is also discussed in the review.

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Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications

Abstract: Treatment with 6 mg/d capsinoids orally appeared to be safe and was associated with abdominal fat loss. Capsinoid ingestion was associated with an increase in fat oxidation that was nearly significant. We identified 2 common genetic variants that may be predictors of therapeutic response.

Cited by 239 publications

References 28 publications

Horizons in the Pharmacotherapy of Obesity

Horizons in the Pharmacotherapy of Obesity

Daily Ingestion of Grains of Paradise (Aframomum melegueta) Extract Increases Whole-Body Energy Expenditure and Decreases Visceral Fat in Humans

Health-promoting properties of compounds derived from Capsicum sp. A review

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