Effects of normal pregnancy on maternal EEG, TCD, and cerebral cortical volume

Luo, Huijuan; Liang, Xinyuan; Cheng, Zhong‐Yuan; Cai, Xiang‐Ran; Feng, Fengling; Zhou, Huan; Tang, Xiaomei; Zhou, Juan; Wang, Dongju; Xiao, Xiaomin

doi:10.1016/j.bandc.2020.105526

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…Consistent with the longitudinal findings described above, cross-sectional studies examining brain structure in mothers compared to non-mothers have shown smaller regional volumes or cortical thickness in various stages of the postpartum period Luo and colleagues observed a thinner cortex in various regions, including the frontal lobe and cingulate gyrus, in nine mothers scanned within 24 hours after delivery compared to a control group of eight nonpregnant women (Luo et al, 2020). These regions corresponded to areas of cerebral blood flow increases and changes in electroencephalography (EEG) measured during the third trimester of pregnancy (Luo et al, 2020). Smaller volumes were also observed in the left striatum of 30 primiparous mothers scanned within the first two months after delivery when compared to 30 nulliparous women (Lisofsky et al, 2016).…”

Section: J O U R N a L P R E -P R O O Fsupporting

confidence: 64%

“…For women pregnant with their first child compared to 33 multiparous pregnant women (Rutherford et al, 2019). Differences in electrophysiological responses have been observed in pregnant women when compared to non-pregnant women in a number of tasks (Fiterman and Raz, 2019;Luo et al, 2020), including a stop-signal task in which pregnant women showed improved performance as well as altered amplitudes of P1, N2 and P3 during stop signals (Fiterman and Raz, 2019).…”

Section: Functional Neuroimagingmentioning

confidence: 99%

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Less can be more: Fine tuning the maternal brain

Pawluski

Hoekzema

Leuner

et al. 2022

Neuroscience & Biobehavioral Reviews

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Section: J O U R N a L P R E -P R O O Fsupporting

confidence: 64%

Section: Functional Neuroimagingmentioning

confidence: 99%

Less can be more: Fine tuning the maternal brain

Pawluski

Hoekzema

Leuner

et al. 2022

Neuroscience & Biobehavioral Reviews

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“…Our results confirm the findings of previous studies in which the MCA CBFV was evaluated by TCD 2,10,14,16,17 . Recording the TCD measurements of all participants by only 2 physicians strengthens the accuracy of the results of this study by eliminating possible biases.…”

Section: Discussionsupporting

confidence: 90%

Middle Cerebral Artery Blood Flow Velocity During Normal Pregnancy

Erkoç Ataoğlu,

Batur Çağlayan,

Nazliel

et al. 2023

The Neurologist

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Background: The present study aimed to evaluate resting middle cerebral artery (MCA) blood flow velocities using transcranial Doppler ultrasound (TCD) in healthy women at different stages of pregnancy, and to compare these velocities with those of normal controls. Methods: A total of 105 healthy normotensive pregnant women and 25 non-pregnant healthy controls were included in the study. We formed 3 groups according to gestational age: first trimester (7 to 13 wk pregnant), second trimester (14 to 28 wk pregnant), and third trimester (29 to 42 wk pregnant). Age, body mass index, heart rate, arterial blood pressure, and hematological data were recorded and TCD was performed on the subjects. Regarding TCD, we evaluated the mean cerebral blood flow velocity, the peak systolic velocity, the end-diastolic flow velocity, S/D ratio, the pulsatility Index (PI) and the resistance Index (RI). Results: The MCA mean blood flow velocities differed significantly among the groups (P<0.001) and were higher in the controls than those of the first trimester, second trimester, and third trimester groups (P<0.01, P<0.001, P<0.001 respectively). The MCA mean and peak blood flow velocities, and the PI and RI decreased significantly with advancing gestation. Conclusions: TCD is a noninvasive and non-toxic method of monitoring the adaptation of the maternal cerebral blood flow in pregnancy. The progressive decreases in the MCA mean and peak blood flow velocities, PI, and RI during gestation may be the result of chemical and neuronal factors. This study supports the need for additional studies using TCD to establish normative cerebral blood flow volumes throughout pregnancy.

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“…Cognitive recombination in pregnant women is related to changes in brain structure and function during pregnancy. Shrinking of the cerebral cortex and changes on electroencephalogram and in cerebral blood flow have been found in pregnant women [17][18][19]. These changes are closely related to intestinal flora and metabolites, of which SCFAs-the major metabolites of intestinal flora-play an important role in the gut-brain axis [20].…”

Section: Discussionmentioning

confidence: 99%

Differences in cognition, short-chain fatty acids and related metabolites in pregnant versus non-pregnant women: a cross-sectional study

Luo

et al. 2022

BMC Pregnancy Childbirth

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Background Pregnancy induces cognitive reorganization which can lead to mental disorders. The aim of this study is to determine differences in cognitive scores, short-chain fatty acids (SCFAs) and related metabolites between pregnant and non-pregnant participants. Methods This cross-sectional study included 67 full-term pregnant women and 31 non-pregnant women. We compared scores of mental state and cognitive assessment tests, as well as serum concentrations of SCFAs, hormones, inflammatory factors, and neurotransmitters between these groups. Results Scores for information processing speed, immediate visual memory, motor response speed and accuracy, execution ability and verbal use ability in the pregnant group were lower than those in the non-pregnant group (p < 0.05 for all tests). Total serum SCFAs in the pregnant group were significantly lower than those in the non-pregnant group (P = 0.031). Among them, acetate and propionate were significantly decreased (P = 0.013 and 0.037, respectively) whereas butyrate was significantly increased (P = 0.035). Serum peptide YY, glucagon-like peptide-1, γ-aminobutyric acid, and dopamine showed no differences between the two groups. However, cortisol, adrenocorticotropic hormone, and acetylcholine were significantly increased in the pregnant group as compared with the non-pregnant group (P = 0.039, 0.016, and 0.012, respectively). Tumor necrosis factor-α was increased and interleukin-10 significantly decreased in the pregnant group (P = 0.045 and 0.019, respectively). Conclusion According to our study findings, cognitive reorganization in the third trimester of pregnancy showed that both the passive storage capacity of working memory and the executive function of online information processing were decreased to varying degrees. At the same time, the changes in total SCFAs, the proportions of SCFAs and related metabolites were also detected. These changes in the internal environment may be increasing the risk of perinatal mental illness.

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Effects of normal pregnancy on maternal EEG, TCD, and cerebral cortical volume

Cited by 7 publications

References 23 publications

Less can be more: Fine tuning the maternal brain

Less can be more: Fine tuning the maternal brain

Middle Cerebral Artery Blood Flow Velocity During Normal Pregnancy

Differences in cognition, short-chain fatty acids and related metabolites in pregnant versus non-pregnant women: a cross-sectional study

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