Effects of noradrenaline on interstitial fluid pressure in induced rat mammary tumours

Tveit, Egil; Hultborn, Ragnar; Weiss, Lilian

doi:10.1016/0304-3835(85)90181-8

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…This was predicted, according to authors, by the Starling principles, as the vascular volume is decreased by vasopressors (thereby increasing relative V i ). These results could also be explained by a decreased capillary flow due to extreme vasoconstriction [ 60 ].…”

Section: Interstitial Pressure (And Transcapillary Flow) Regulation D...mentioning

confidence: 99%

Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?

Dargent,

Dumargne,

Labruyère

et al. 2023

j intensive care

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Background While not traditionally included in the conceptual understanding of circulation, the interstitium plays a critical role in maintaining fluid homeostasis. Fluid balance regulation is a critical aspect of septic shock, with a well-known association between fluid balance and outcome. The regulation of transcapillary flow is the first key to understand fluid homeostasis during sepsis. Main text Capillary permeability is increased during sepsis, and was classically considered to be necessary and sufficient to explain the increase of capillary filtration during inflammation. However, on the other side of the endothelial wall, the interstitium may play an even greater role to drive capillary leak. Indeed, the interstitial extracellular matrix forms a complex gel-like structure embedded in a collagen skeleton, and has the ability to directly attract intravascular fluid by decreasing its hydrostatic pressure. Thus, interstitium is not a mere passive reservoir, as was long thought, but is probably major determinant of fluid balance regulation during sepsis. Up to this date though, the role of the interstitium during sepsis and septic shock has been largely overlooked. A comprehensive vision of the interstitium may enlight our understanding of septic shock pathophysiology. Overall, we have identified five potential intersections between septic shock pathophysiology and the interstitium: 1. increase of oedema formation, interacting with organ function and metabolites diffusion; 2. interstitial pressure regulation, increasing transcapillary flow; 3. alteration of the extracellular matrix; 4. interstitial secretion of inflammatory mediators; 5. decrease of lymphatic outflow. Conclusions We aimed at reviewing the literature and summarizing the current knowledge along these specific axes, as well as methodological aspects related to interstitium exploration.

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Section: Interstitial Pressure (And Transcapillary Flow) Regulation D...mentioning

confidence: 99%

Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?

Dargent,

Dumargne,

Labruyère

et al. 2023

j intensive care

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“…Pharmacological as well as anatomical abnormalities have been documented in tumour blood vessels, though the situation is far from clear-cut. Thus, experimental studies have suggested either increased (Young et al, 1979;Tveit et al, 1981), similar (Mattsson et al, 1982) or decreased (Wickersham et al, 1977) sensitivity to vasoactive stimuli in the tumour vascular bed compared to normal tissue. These differences have been attributed to the transplantation area of the tumour, the type of tumour and the different techniques used for measuring blood flow (Suzuki et al, 1984).…”

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confidence: 99%

Effects of tumour cells on angiogenesis and vasoconstrictor responses in sponge implants in mice

Andrade¹,

Bakhle²,

Hart³

et al. 1992

Br J Cancer

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SummaryThe effects of tumour cells (Colon 26) on the development and response of new blood vessels to different vasoconstrictors (platelet activating factor; PAF, endothelin-1, angiotensin II, adrenalin and 5-hydroxytryptamine) have been investigated. Sponge implants in mice were used to host tumour cells while washout of '33Xe was employed to assess local blood flow in the implanted sponges.By 14 days after implantation the response of vessels in tumour-bearing implants to the various vasoconstrictors generally was decreased compared to that obtained in control sponge implants or adjacent normal skin. Thus at this time point the tl/2 for '33Xe washout from control sponges treated with adrenalin (0.5 pg) was 30 ± 4 min whereas in tumour-bearing sponges it was 5 ± 1 min.This decreased sensitivity in tumour vessels was probably not due to a complete lack of contractile elements since actin was demonstrated by immunohistochemistry around blood vessels in both types of implant.The results of the present study have shown that the pharmacological responses of blood vessels in a growing tumour, Colon 26, differed from the responses of vessels of a similar age in non-neoplastic tissue. These results appear to suggest that the different angiogenic stimuli released from tumour tissue may markedly influence pharmacological reactivity of newly formed blood vessels.Tumour angiogenesis, the formation of capillary vessels induced by neoplastic cells with eventual development of a functional microcirculatory network within the growing mass, is a process analogous to the formation of capillary vessels in granulation tissue during wound repair (Warren, 1979). Morphological abnormalities in vessels in either situation have frequently been reported (Schoelfl, 1963;Warren, 1979;Jain 1988;Vaupel et al., 1989). However, compared to other angiogenic stimuli, tumours induce a very intense and persistent response (Folkman & Klagsbrun, 1987) so that more severe abnormalities may be observed in tumour vessels; this tendency is accentuated in rapidly growing neoplasms (Vaupel et al., 1989). Pharmacological as well as anatomical abnormalities have been documented in tumour blood vessels, though the situation is far from clear-cut. Thus, experimental studies have suggested either increased (Young et al., 1979;Tveit et al., 1981), similar (Mattsson et al., 1982) or decreased (Wickersham et al., 1977) sensitivity to vasoactive stimuli in the tumour vascular bed compared to normal tissue. These differences have been attributed to the transplantation area of the tumour, the type of tumour and the different techniques used for measuring blood flow (Suzuki et al., 1984). The washout of locally injected radioactive '33Xe (Peterson, 1979) has been shown to be a reliable index of tumour blood flow when applied to relatively small, superficially located cancers (Kallman et al., 1972). This technique has also been used for examining the influence of vasoactive drugs on local blood flow in tumours and normal subcutaneous tissue (Mattsson et al., 1980;198...

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Microanalysis of platinum in tumor nodules after cisplatin treatment with different modes of local administration

Moretto

Duvillard²,

Beaugerie³

et al. 1999

Nuclear Instruments and Methods in Physics Research Section B:

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Effects of noradrenaline on interstitial fluid pressure in induced rat mammary tumours

Cited by 4 publications

References 10 publications

Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?

Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?

Effects of tumour cells on angiogenesis and vasoconstrictor responses in sponge implants in mice

Microanalysis of platinum in tumor nodules after cisplatin treatment with different modes of local administration

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