Effects of Noradrenaline and Dopamine on Supraspinal Fatigue in Well-Trained Men

Klass, Malgorzata; Roelands, Bart; Lévénez, Morgan; Fontenelle, Vinciane; Pattyn, Nathalie; Meeusen, Romain; Duchateau, Jacques

doi:10.1249/mss.0b013e318265f356

Cited by 65 publications

(66 citation statements)

References 40 publications

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“…For example, several of the modulating factors that contribute to perceived fatigability, including the levels of blood glucose (49), core temperature (50), arousal (36), and mood (64), can all modulate the capacity of the individual to generate the required amount of voluntary activation, which is a factor that influences performance fatigability. Similarly, afferent feedback generated during high-intensity exercise can influence the adjustments required to maintain homeostasis and thereby contribute to perceived fatigability (33,59).…”

Section: Proposed Taxonomymentioning

confidence: 99%

“…As one example of such a mechanistic study, Klass et al (36) compared the influence of three drug conditions on the performance of 10 cyclists and triathletes on a time trial. The drug conditions, one of which was administered in each experimental session, comprised a placebo or a reuptake inhibitor for either noradrenaline (reboxetine) or dopamine (methylphenidate).…”

Section: Human Performance and Fatiguementioning

confidence: 99%

“…Given a specific critical power capability, however, performance during an individual time trial may be limited by factors that contribute to perceived fatigability, such as those that establish the performer's psychological state. Power production can be modulated, for example, by interventions that manipulate homeostasis and thereby alter ratings of perceived exertion (36,44). Future studies are needed to determine the relative significance of the various adjustments that influence ratings of perceived exertion.…”

Section: Translating Fatigue To Performancementioning

confidence: 99%

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Translating Fatigue to Human Performance

Enoka

Duchateau

2016

Medicine &Amp; Science in Sports &Amp; Exercise

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608

582

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Despite flourishing interest in the topic of fatigue—as indicated by the many presentations on fatigue at the 2015 annual meeting of the American College of Sports Medicine—surprisingly little is known about its impact on human performance. There are two main reasons for this dilemma: (1) the inability of current terminology to accommodate the scope of the conditions ascribed to fatigue, and (2) a paucity of validated experimental models. In contrast to current practice, a case is made for a unified definition of fatigue to facilitate its management in health and disease. Based on the classic two-domain concept of Mosso, fatigue is defined as a disabling symptom in which physical and cognitive function is limited by interactions between performance fatigability and perceived fatigability. As a symptom, fatigue can only be measured by self-report, quantified as either a trait characteristic or a state variable. One consequence of such a definition is that the word fatigue should not be preceded by an adjective (e.g., central, mental, muscle, peripheral, and supraspinal) to suggest the locus of the changes responsible for an observed level of fatigue. Rather, mechanistic studies should be performed with validated experimental models to identify the changes responsible for the reported fatigue. As indicated by three examples (walking endurance in old adults, time trials by endurance athletes, and fatigue in persons with multiple sclerosis) discussed in the review, however, it has proven challenging to develop valid experimental models of fatigue. The proposed framework provides a foundation to address the many gaps in knowledge of how laboratory measures of fatigue and fatigability impact real-world performance.

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Section: Proposed Taxonomymentioning

confidence: 99%

Section: Human Performance and Fatiguementioning

confidence: 99%

Section: Translating Fatigue To Performancementioning

confidence: 99%

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Translating Fatigue to Human Performance

Enoka

Duchateau

2016

Medicine &Amp; Science in Sports &Amp; Exercise

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608

582

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“…The NA reuptake inhibitor reboxetine has been shown to exert no effect or negative effects on endurance exercise performance in normal ambient temperature (52, 72, 79). However, it is not certain that this is solely through central mechanisms, as reboxetine can also have peripheral effects through the sympathetic system, such as vasodilatation and increased heart rate, and an influence of these on peformance cannot be ruled out.…”

Section: Brain Changes Associated With Performancementioning

confidence: 99%

Neural Contributions to Muscle Fatigue

Taylor

Amann

Duchateau

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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375

198

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During exercise, there is a progressive reduction in the ability to produce muscle forces. Processes within the nervous system, as well as within the muscles contribute to this fatigue. In addition to impaired function of the motor system, sensations associated with fatigue, and impairment of homeostasis can contribute to impairment of performance during exercise. This review discusses some of the neural changes that accompany exercise and the development of fatigue. The role of brain monoaminergic neurotransmitter systems in whole-body endurance performance is discussed, particularly with regard to exercise in hot environments. Next, fatigue-related alterations in the neuromuscular pathway are discussed in terms of changes in motor unit firing, motoneuron excitability and motor cortical excitability. These changes have mostly been investigated during single-limb isometric contractions. Finally, the small-diameter muscle afferents that increase firing with exercise and fatigue are discussed. These afferents have roles in cardiovascular and respiratory responses to exercise, and in impairment of exercise performance through interaction with the motor pathway, as well as providing sensations of muscle discomfort. Thus, changes at all levels of the nervous system including the brain, spinal cord, motor output, sensory input and autonomic function occur during exercise and fatigue. The mix of influences and the importance of their contribution varies with the type of exercise being performed.

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“…This might have provided more information on the ratio of peripheral and central fatigue. Certainly since we were already able to show that a noradrenaline reuptake inhibitor induces a greater decrease in voluntary activation compared to a placebo after a cycling effort in normal ambient temperature (Klass et al 2012). It might be interesting to look at how different neurotransmitter systems may influence the onset of fatigue (peripheral vs central/supraspinal) in differing environments.…”

Section: Limitations and Future Perspectivesmentioning

confidence: 99%

The influence of a mild thermal challenge and severe hypoxia on exercise performance and serum BDNF

et al. 2015

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Exercise capacity was significantly reduced due to an increase in altitude (3800 m; -34.3%) or a 10 °C increase in ambient temperature (-3.2%). The combination of both stressors showed to be additive (-38.0 %). Altitude induced an increase in RT and RT variability presenting a deterioration in cognitive functioning during acute hypoxia. Exercise significantly increased BDNF, but no effect of altitude on the BDNF concentration was observed.

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Effects of Noradrenaline and Dopamine on Supraspinal Fatigue in Well-Trained Men

Abstract: These results suggest that noradrenaline, but not dopamine reuptake inhibition, contributes to the development of central/supraspinal fatigue after a prolonged cycling exercise performed in temperate conditions.

Cited by 65 publications

References 40 publications

Translating Fatigue to Human Performance

Translating Fatigue to Human Performance

Neural Contributions to Muscle Fatigue

The influence of a mild thermal challenge and severe hypoxia on exercise performance and serum BDNF

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