Effects of Nonsystemic Ventricular Pacing in Patients with Transposition of the Great Arteries and Atrial Redirection

Horovitz, Alice; Guillebon, Maxime De; Geldorp, Irene E. van; Bordachar, Pierre; Roubertie, François; Iriart, Xavier; Douard, H.; Haı̈ssaguerre, Michel; Thambo, Jean-Benoît

doi:10.1111/j.1540-8167.2011.02271.x

Cited by 20 publications

(7 citation statements)

References 36 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yeo et al demonstrated that chronic univentricular subpulmonary LV pacing in CCTGA patients predicted long-term deterioration of SRV function and NYHA class [19]. In a similar study, Horovitz et al evaluated the longterm effects of chronic LV pacing in DTGA patients on cardiac function, ventricular dyssynchrony and functional status [34]. Again, long-term chronic LV pacing was associated with decreased functional status, impaired SRV function and enhanced inter-and intraventricular dyssynchrony.…”

Section: Systemic Right Ventriclementioning

confidence: 99%

“…More recently, Karpawich et al used an invasive measure of contractility (dP/dt-max) with a catheter within the SRV as a pre-implant screening tool in CHD patients [22]. Six DTGA and 2 CCTGA adult patients (age 25 [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]) showed an initial dP/dt-max improvement of ≥15% and received CRT. During a median follow-up time of 2.7 years, hemodynamic benefits of CRT persisted in all patients.…”

Section: Single Center Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Cardiac resynchronization therapy for the failing systemic right ventricle: A systematic review

Kharbanda

Moore²,

Taverne

et al. 2020

International Journal of Cardiology

View full text Add to dashboard Cite

Patients with a systemic right ventricle (SRV) are at high risk for development of heart failure early in life. An SRV is encountered in patients with congenitally corrected transposition of the great arteries (CCTGA) or dextrotransposition of the great arteries (DTGA) with previous atrial switch repair (Mustard or Senning procedure). Progressive heart failure is one of the leading cause of mortality in these patients. Therefore, cardiac resynchronization therapy (CRT) has gained increasing momentum for use in this challenging congenital heart disease (CHD) population. However, current guidelines differ in recommendations for CRT in patients with an SRV as evidence supporting CRT has thus far only been described in case reports and retrospectively in relatively small study populations. In fact, the European Society of Cardiology Guideline for the management of grown-up congenital heart disease consider CRT to be 'experimental' in this population. This systematic review critically summarizes current literature on CRT in SRV patients and provides future perspectives for further research in this challenging and growing CHD population.

show abstract

Section: Systemic Right Ventriclementioning

confidence: 99%

Section: Single Center Studiesmentioning

confidence: 99%

Cardiac resynchronization therapy for the failing systemic right ventricle: A systematic review

Kharbanda

Moore²,

Taverne

et al. 2020

International Journal of Cardiology

View full text Add to dashboard Cite

show abstract

“…Medical therapy and routine surveillance may also extend survival. [57][58][59][60] New drugs may provide selective pulmonary arterial vasodilation. Incorporation of lifestyle changes can minimize systemic hypertension, avoidance of obesity can lessen the effects of higher pulmonary resistance, and exercise walking regimens can help to augment systemic venous return.…”

Section: Lessons Learned Over the Last 20 Yearsmentioning

confidence: 99%

Fontan Conversion

Mavroudis

Deal

2016

World J Pediatr Congenit Heart Surg

View full text Add to dashboard Cite

Early survival after the Fontan operation has improved significantly leading to a lifetime of Fontan circulation for patients. There is a natural progression of pulmonary artery pressure during the human lifetime that is easily tolerated in two-ventricle physiology but is deleterious for single-ventricle physiology. Obstructions in the venous to pulmonary artery pathway and pulmonary venous return or ventricular outflow, atrioventricular valve dysfunction (regurgitation), pulmonary arteriovenous malformations, venous thrombosis, and the development of atrial arrhythmias can lead to reduced functional status. These complications have been demonstrated in older patients with largely atriopulmonary connections owing to time accrual and unfavorable flow characteristics. Various surgical and catheter interventions aimed at reducing morbidity and mortality have been attempted to treat these identifiable abnormalities. The purpose of this article is to review the extant literature on Fontan Conversion and to assess the lessons learned over 20 years.

show abstract

“…[24][25][26] Shortly after BiV pacing has been approved for clinical application (United States Food and Drug Administration in 2001), CRT has been recommended as an additional therapy for the treatment of patients with heart failure in the 2002 update of the American College of Cardiology/American Heart Association/North American Society of Pacing and Electrophysiology (ACC/AHA/NASPE). 27 Chapter 2 (1): [75][76][77][78][79][80][81][82]., with permission). 57 Nowadays, CRT constitutes an established way of treatment for patients suffering from severe heart failure associated with conduction disturbances.…”

Section: Toward Treatment Of Dyssynchrony: Cardiac Resynchronization Therapymentioning

confidence: 99%

“…In this group of patients LV pacing (i.e., non-systemic ventricular pacing) is associated with lower functional and exercise capacity, lower systemic ventricular function and higher degree of inter-and intraventricular dyssynchrony. 79 Adverse effects induced by pacing the non-systemic ventricle may be of major clinical importance since they may induce additional risk for dysfunction of the systemic RV in these patients who do already have high risk for cardiac dysfunction. We found in patients with status post Senning or Mustard procedure for transposition of the great arteries that acute hemodynamic effects of endocardial systemic ventricular pacing and biventricular pacing were significantly and equally better than those of non-systemic ventricular pacing (chapter 8).…”

Section: Optimal Pacing In Congenital Heart Diseasementioning

confidence: 99%

Improving ventricular pacing in adults and children : to treat or to avoid dyssynchrony-induced cardiac failure

Geldorp

View full text Add to dashboard Cite

People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

show abstract

Effects of Nonsystemic Ventricular Pacing in Patients with Transposition of the Great Arteries and Atrial Redirection

Abstract: Long-term pacing of the nonsystemic ventricle in patients with atrial switch for TGA was associated with significantly impaired functional status, exercise capacity, and systemic ventricular function.

Cited by 20 publications

References 36 publications

Cardiac resynchronization therapy for the failing systemic right ventricle: A systematic review

Cardiac resynchronization therapy for the failing systemic right ventricle: A systematic review

Fontan Conversion

Improving ventricular pacing in adults and children : to treat or to avoid dyssynchrony-induced cardiac failure

Contact Info

Product

Resources

About