Effects of Noninvasive Brain Stimulation (NIBS) on Cognitive Impairment in Mild Cognitive Impairment and Alzheimer Disease

Wang, Tao; Du, Yong; Xiong, Momiao; Yang, Zhengcong; Ren, Long; He, Lin; Jiang, Yiguo; McClure, Morgan A.; Mu, Qiwen

doi:10.1097/wad.0000000000000464

Cited by 18 publications

(18 citation statements)

References 63 publications

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“…[114][115][116] In addition, the beneficial effect of tDCS treatment on cognitive performance has also been demonstrated in patients with mild cognitive impairment and Alzheimer's disease. 69,117 Furthermore, stimulation with tDCS in aging individuals improved performance on semantic word generation task, 111 naming, 118 associative learning task, 119 and delayed episodic memory tasks. [120][121][122]…”

Section: Cognitive and Memory Deficitsmentioning

confidence: 96%

“…A systematic review found that eight of 12 studies using rTMS application over DLPFC in elderly people showed significant cognitive improvements, 65 and a meta‐analysis study concluded that rTMS has positive effect on cognitive improvement in healthy aging and Alzheimer's disease. 66 In addition, numerous meta‐analysis studies have shown that the application of rTMS produces precognitive effects in patients with mild cognitive impairment and Alzheimer's disease 67 , 68 , 69 , 70 and in patients with cognitive deficits and dementia. 71 , 72 , 73 The beneficial effect of rTMS treatment has also been shown in improving episodic memory in cognitively deficient individuals 74 and in reverting cognitive impairments in celiac disease patients.…”

Section: Noninvasive Brain Stimulationmentioning

confidence: 99%

“…Systematic reviews and meta‐analysis studies have shown that treatment with tDCS in elderly people caused slowdown in the progression of cognitive deterioration 113 and improved performance across the wide range of cognitive and memory tasks 114–116 . In addition, the beneficial effect of tDCS treatment on cognitive performance has also been demonstrated in patients with mild cognitive impairment and Alzheimer's disease 69,117 . Furthermore, stimulation with tDCS in aging individuals improved performance on semantic word generation task, 111 naming, 118 associative learning task, 119 and delayed episodic memory tasks 120–122 …”

Section: Noninvasive Brain Stimulationmentioning

confidence: 99%

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Therapeutic potential of brain stimulation techniques in the treatment of mental, psychiatric, and cognitive disorders

et al. 2022

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Treatment for brain diseases has been disappointing because available medications have failed to produce clinical response across all the patients. Many patients either do not respond or show partial and inconsistent effect, and even in patients who respond to the medications have high relapse rates. Brain stimulation has been seen as an alternative and effective remedy. As a result, brain stimulation has become one of the most valuable therapeutic tools for combating against brain diseases. In last decade, studies with the application of brain stimulation techniques not only have grown exponentially but also have expanded to wide range of brain disorders. Brain stimulation involves passing electric currents into the cortical and subcortical area brain cells with the use of noninvasive as well as invasive methods to amend brain functions. Over time, technological advancements have evolved into the development of precise devices; however, at present, most used noninvasive techniques are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), whereas the most common invasive technique is deep brain stimulation (DBS). In the current review, we will provide an overview of the potential of noninvasive (rTMS and tDCS) and invasive (DBS) brain stimulation techniques focusing on the treatment of mental, psychiatric, and cognitive disorders.

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Section: Cognitive and Memory Deficitsmentioning

confidence: 96%

Section: Noninvasive Brain Stimulationmentioning

confidence: 99%

Section: Noninvasive Brain Stimulationmentioning

confidence: 99%

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Therapeutic potential of brain stimulation techniques in the treatment of mental, psychiatric, and cognitive disorders

et al. 2022

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“…Anodal stimulation in MCI patients also shows improved performance on immediate verbal memory ( Fileccia et al, 2019 ). Several meta-analyses ( Wang et al, 2021 ; Majdi et al, 2022 ) have confirmed the efficacy of anodal stimulation on the DLPFC in MCI and AD patients on memory tests. However, a recent review ( Ciullo et al, 2021 ) reported that evidence of a positive effect on memory is inconclusive in AD and weak in MCI.…”

Section: Introductionmentioning

confidence: 96%

Home-based transcranial direct current stimulation in mild neurocognitive disorder due to possible Alzheimer’s disease. A randomised, single-blind, controlled-placebo study

et al. 2023

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IntroductionMild neurocognitive disorder (mNCD), a pre-dementia stage close to Mild Cognitive Impairment, shows a progressive and constant decline in the memory domain. Of the non-pharmacological therapeutic interventions that may help to decelerate the neurodegenerative progress, transcranial direct current stimulation (tDCS) shows beneficial effects on the learning curve, immediate recall, immediate verbal memory and executive functions. The purpose of this research was to study the effect of tDCS on general cognition, immediate and delayed memory and executive functions by comparing an active group with a placebo group of mNCD patients.MethodsParticipants were 33 mNCD due to possible AD, randomly assigned to two groups: 17 active tDCS and 16 placebo tDCS. Ten sessions of tDCS were conducted over the left dorsolateral prefrontal cortex. Several neuropsychological scales were administered to assess the primary outcome measures of general cognitive function, immediate and delayed memory and learning ability, whereas the secondary outcome measures included executive function tests. All participants were evaluated at baseline and at the end of the intervention. Mixed ANOVAs were performed.ResultsSignificant effects were obtained on general cognitive function, immediate and delayed memory and learning ability, with increases in scores in the active tDCS group. However, there were no significant effects on executive function performance.ConclusionThe present study demonstrated the effectiveness of tDCS in an active tDCS group, compared to a placebo group, in improving general cognition and immediate and delayed memory, as previous studies found. Taken together, our data suggest that tDCS is a simple, painless, reproducible and easy technique that is useful for treating cognitive alterations found in neurodegenerative diseases.

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“…Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique which has been considered as a well-tolerated and adjustable technology without serious adverse effects 7 . It has been widely applied to improve cognitive impairment in MCI research in recent years.…”

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confidence: 99%

High-Frequency rTMS Could Improve Impaired Memory in Mild Cognitive Impairment Patients in China

Wang,

Guo,

et al. 2023

Alzheimer Disease &Amp; Associated Disorders

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Objective: The purpose of this study was to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on improving memory deficits in mild cognitive impairment (MCI), as well as to provide visualized evidence for neuronal specificity by using resting-state functional magnetic resonance imaging. Materials and Methods: Forty MCI patients were enrolled to receive 10-session and sham-controlled 10Hz-rTMS over the left dorsolateral prefrontal cortex. The resting-state functional magnetic resonance imaging combined with memory scales assessment were performed before and after the intervention. To elucidate the therapeutic mechanism of rTMS, amplitude of low-frequency fluctuations (ALFF) and functional connectivity were calculated. The Pearson correlation was used to measure the relationship between ALFF and memory performance. Results: Compared with the sham group, ALFF significantly increased in the right insula, right inferior frontal gyrus-opercular part, and decreased in the left middle occipital gyrus, left angular gyrus, and left lingual gyrus after rTMS. The change in Auditory Verbal Learning Test scores were negatively correlated with ALFF decreases in the left lingual gyrus. Functional connectivity significantly increased between the posterior cingulate cortex and right supramarginal gyrus, and decreased between the right frontoinsular cortex and right supramarginal gyrus after intervention. Conclusion: High-frequency rTMS over the left dorsolateral prefrontal cortex could facilitate improvement on impaired memory in patients with MCI via modulating the neuronal activity and brain network.

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Effects of Noninvasive Brain Stimulation (NIBS) on Cognitive Impairment in Mild Cognitive Impairment and Alzheimer Disease

Cited by 18 publications

References 63 publications

Therapeutic potential of brain stimulation techniques in the treatment of mental, psychiatric, and cognitive disorders

Therapeutic potential of brain stimulation techniques in the treatment of mental, psychiatric, and cognitive disorders

Home-based transcranial direct current stimulation in mild neurocognitive disorder due to possible Alzheimer’s disease. A randomised, single-blind, controlled-placebo study

High-Frequency rTMS Could Improve Impaired Memory in Mild Cognitive Impairment Patients in China

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