Effects of non-steroidal anti-inflammatory drug (NSAID) diclofenac exposure in mussel Mytilus galloprovincialis

González-Rey, María; Bebianno, Maria João

doi:10.1016/j.aquatox.2014.01.011

Cited by 172 publications

(34 citation statements)

References 80 publications

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“…AChE is a key enzyme commonly inhibited by xenobiotic compounds such as organophosphate, carbamate pesticides, polycyclic aromatic hydrocarbon, metals and surfactants (Lionetto et al, 2003;Sole et al, 2010;Gonzalez-Rey and Bebianno, 2014). In the present study, significant inhibition of AChE activity was observed in oysters from XZ, which was coincided with the elevated metal concentrations.…”

Section: Discussionmentioning

confidence: 52%

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

Tian

Song

et al. 2016

Marine Pollution Bulletin

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a b s t r a c t a r t i c l e i n f oArticle history: Received 9 January 2016 Received in revised form 26 July 2016 Accepted 29 July 2016 Available online xxxx An integrative biomarker approach was employed to evaluate the environmental quality of the north coast of Shandong Peninsula along the southern Bohai Sea of China, where pollution is an imminent threat due to rapid urbanization and industrialization. A battery of biomarkers and the metal bioaccumulation in tissues of native oyster Crassostrea gigas were measured under field conditions. Integrative biomarker index (IBR) and metal body burden were calculated to differentiate the pollution status of seven sampling sites. According to our results, Xinzhuang (XZ) site was the most severely contaminated, with the highest IBR value of 3.58, while the lowest IBR value (0.04) was obtained at Penglai (PL). Such an integrated biomarker approach was proved as a useful method for environmental quality assessment in the study area.

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Section: Discussionmentioning

confidence: 52%

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

Tian

Song

et al. 2016

Marine Pollution Bulletin

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“…As suggested by the authors, alterations induced by diclofenac in terms of AChE activity can be modulated by SOD activity in digestive gland, and by the vitellogenin-like protein levels expressed by female of M. galloprovincialis. Rather than being a mere interference in cholinergic neurotransmission function, Gonzalez-Rey and Bebiano (2014) suggested that these results implicate the alteration of estrogenic activity in diclofenac's neurotoxicity. This work confirmed that diclofenac, at a concentration often observed in surface waters, may induce tissue-specific biomarker responses, including impairment of cholinesterasic activity.…”

Section: Diclofenacmentioning

confidence: 95%

Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers

Oliveira

Antunes

Gonçalves

et al. 2015

Ecotoxicology and Environmental Safety

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“…[101], transient tissue-specific changes were reported after a 7 day exposure to 0.25 mg l 21 diclofenac [98], a concentration well within the range reported in seawater (table 1). Pharmaceuticals are present in marine ecosystems as mixtures complicating risk assessments.…”

mentioning

confidence: 88%

“…Examples of reported adverse effects for analgesics include reduced feeding rates [96], impacts on survival [97], reduced mussel byssus strength [90] and changes in immune response [96] and biochemical markers [98]. Studies have tended to focus on endpoints related to the therapeutic mode of action of the pharmaceutical.…”

Section: Biological Impacts In Marine Organisms (A) Marine Ecotoxicolmentioning

confidence: 99%

Sources, impacts and trends of pharmaceuticals in the marine and coastal environment

Gaw

Thomas

Hutchinson

2014

Phil. Trans. R. Soc. B

380

149

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There has been a significant investment in research to define exposures and potential hazards of pharmaceuticals in freshwater and terrestrial ecosystems. A substantial number of integrated environmental risk assessments have been developed in Europe, North America and many other regions for these situations. In contrast, comparatively few empirical studies have been conducted for human and veterinary pharmaceuticals that are likely to enter coastal and marine ecosystems. This is a critical knowledge gap given the significant increase in coastal human populations around the globe and the growth of coastal megacities, together with the increasing importance of coastal aquaculture around the world. There is increasing evidence that pharmaceuticals are present and are impacting on marine and coastal environments. This paper reviews the sources, impacts and concentrations of pharmaceuticals in marine and coastal environments to identify knowledge gaps and suggests focused case studies as a priority for future research.

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Effects of non-steroidal anti-inflammatory drug (NSAID) diclofenac exposure in mussel Mytilus galloprovincialis

Cited by 172 publications

References 80 publications

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers

Sources, impacts and trends of pharmaceuticals in the marine and coastal environment

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