Effects of non‐rapid eye movement sleep on the cortical synaptic expression of GluA1‐containing AMPA receptors
Fabio Squarcio,
Giulio Tononi,
Chiara Cirelli
Abstract:Converging electrophysiological, molecular and ultrastructural evidence supports the hypothesis that sleep promotes a net decrease in excitatory synaptic strength, counteracting the net synaptic potentiation caused by ongoing learning during waking. However, several outstanding questions about sleep‐dependent synaptic weakening remain. Here, we address some of these questions by using two established molecular markers of synaptic strength, the levels of the AMPA (alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole prop… Show more
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