Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review

Sanada, Kenji; López, Marta Díez; Valero, Montserrat Salas; Pérez-Yus, María C.; Demarzo, Marcelo; Garcı́a-Toro, Mauro; Garcı́a-Campayo, Javier

doi:10.1186/s13075-015-0789-9

Cited by 32 publications

(27 citation statements)

References 36 publications

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“…Combined, these results indicate that an exercise intervention may reduce systemic IL-8, but increase IL-10. Available evidence from a systematic review (mainly based on the studies above) suggests that exercise interventions may reduce systemic IL-6 and IL-8 levels [ 30 ]. Thus, these results differ from the results of the present study regarding muscle levels of pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, while short-term exercise seems to increase cytokine levels, a few recent reports have shown reductions in pro-inflammatory cytokine levels in response to long-term exercise in FMS. A systematic review based on nine articles concluded that, despite minimal evidence, exercise interventions might act as an anti-inflammatory treatment in FMS patients by reducing circulating IL-6 and IL-8 levels [ 30 ]. Further, in FMS patients subjected to 15 weeks of Nordic walking, changes of insulin growth factor-1 (IGF-1) correlated positively to changes of pain threshold, indicating a possible beneficial role for IGF-1 during exercise [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia

et al. 2016

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BackgroundThis study aimed at investigating the effect of a resistance exercise intervention on the interstitial muscle levels of pro-inflammatory cytokines in fibromyalgia (FMS) and healthy controls (CON).MethodsTwenty-four female patients with FMS (54 ± 8 years) and 27 female CON (54 ± 9 years) were subjected to intramuscular microdialysis of the most painful vastus lateralis muscle before and after 15 weeks of progressive resistance exercise twice per week. Baseline dialysates were sampled in the resting muscle 140 min after insertion of the microdialysis catheter. The participants then performed repetitive dynamic contractions (knee extension) for 20 min, followed by 60 min rest. Pain intensity was assessed with a 0–100 mm visual analogue scale (VAS), and fatigue was assessed with Borg’s RPE throughout microdialysis. Dialysates were sampled every 20 min and analyzed with Luminex for interleukin (IL)-1β, tumor necrosis factor (TNF) alpha, IL-6, and IL-8.ResultsAt both sessions and for both groups the dynamic contractions increased pain (P < 0.012) and fatigue (P < 0.001). The levels of TNF were lower in the FMS group than the CON group at both sessions (P < 0.05), but none of the other cytokines differed between the groups. IL-6 and IL-8 increased after the dynamic contractions in both groups (P < 0.010), while TNF increased only in CON (P < 0.05) and IL-1β did not change. Overall pain intensity was reduced after the 15 weeks of resistance exercise in FMS (P < 0.05), but there was no changes in fatigue or cytokine levels.ConclusionProgressive resistance exercise for 15 weeks did not affect the interstitial levels of IL-1β, TNF, IL-6, and IL-8 in the vastus lateralis muscle of FMS patients or CON.Trial registrationClinicaltrials.gov NCT01226784, registered 21 October 2010.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia

et al. 2016

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“…However, this is not a general finding since one study indicates that the higher levels of IL-8 are not correlated with pain [ 33 ]. Several studies have shown an increased level in serum and/or plasma for IL-1, IL-6, IL-8 as well as TNF in patients with FM compared to healthy controls [ 29 , 32 , 35 – 40 ], although this is not a general finding [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

“…Based on previous research we hypothesized that there are differences in the levels of pro-inflammatory cytokines in patients with FM compared to healthy controls [ 32 , 55 ] and that there is a correlation between the level of pro-inflammatory cytokines and the level of induced pain as well as fatigue during a low-force muscle exercise. Hence, the primary aim of this study was to investigate the levels of pro-inflammatory cytokines released in the vastus lateralis muscle during repetitive dynamic contractions of the quadriceps muscle in patients with FM and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Levels of Pro-Inflammatory Cytokines Released in the Vastus Lateralis Muscle of Patients with Fibromyalgia and Healthy Controls during Contractions of the Quadriceps Muscle – A Microdialysis Study

et al. 2015

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ObjectiveFibromyalgia is associated with central hyperexcitability, but it is suggested that peripheral input is important to maintain central hyperexcitability. The primary aim was to investigate the levels of pro-inflammatory cytokines released in the vastus lateralis muscle during repetitive dynamic contractions of the quadriceps muscle in patients with fibromyalgia and healthy controls. Secondarily, to investigate if the levels of pro-inflammatory cytokines were correlated with pain or fatigue during these repetitive dynamic contractions.Material and Methods32 women with fibromyalgia and 32 healthy women (controls) participated in a 4 hour microdialysis session, to sample IL-1β, IL-6, IL-8, and TNF from the most painful point of the vastus lateralis muscle before, during and after 20 minutes of repeated dynamic contractions. Pain (visual analogue scale; 0–100) and fatigue Borg’s Rating of Perceived Exertion Scale; 6–20) were assessed before and during the entire microdialysis session.ResultsThe repetitive dynamic contractions increased pain in the patients with fibromyalgia (P < .001) and induced fatigue in both groups (P < .001). Perceived fatigue was significantly higher among patients with fibromyalgia than controls (P < .001). The levels of IL-1β did not change during contractions in either group. The levels of TNF did not change during contractions in patients with fibromyalgia, but increased in controls (P < .001) and were significantly higher compared to patients with fibromyalgia (P = .033). The levels of IL-6 and IL-8 increased in both groups alike during and after contractions (P’s < .001). There were no correlations between pain or fatigue and cytokine levels after contractions.ConclusionThere were no differences between patients with fibromyalgia and controls in release of pro-inflammatory cytokines, and no correlations between levels of pro-inflammatory cytokines and pain or fatigue. Thus, this study indicates that IL-1β, IL-6, IL-8, and TNF do not seem to play an important role in maintenance of muscle pain in fibromyalgia.

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“…De hecho, evidencias previas indican que el ejercicio físico desencadena un proceso análgesico sobre el estado álgico (353).…”

Section: Tratamiento Farmacológicounclassified

Eficacia analgésica del tratamiento invasivo miofascial (punción seca) en fibromialgia

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Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review

Cited by 32 publications

References 36 publications

Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia

Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia

Comparison of the Levels of Pro-Inflammatory Cytokines Released in the Vastus Lateralis Muscle of Patients with Fibromyalgia and Healthy Controls during Contractions of the Quadriceps Muscle – A Microdialysis Study

Eficacia analgésica del tratamiento invasivo miofascial (punción seca) en fibromialgia

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