Effects Of Non-periodized And Linear Periodized Combined Exercise Training On Insulin Resistance Indicators In Adults With Obesity: A Randomized Controlled Trial

Abstract

Background The aim was to verify the effect of non-periodized and linear periodized combined (aerobic more resistance) exercise training on insulin resistance markers in adults with obesity. Methods Was conducted a blinded randomized controlled trial with three groups of individuals with obesity (BMI, 30–39.9 kg/m²): control group (CG, n = 23), non-periodized group (NG, n = 23), and periodized group (PG, n = 23). The NG and PG performed aerobic and resistance exercises in the same session in aerobic-resistance order for 16 weeks. Both intervention groups trained three sessions weekly, with total duration of 60 minutes each. The aerobic training of the NG had duration of 30 min always between 50–59% of the reserve heart rate (HRres), while resistance part was compost of 6 exercise, performed always in 2 × 10–12 maximum repetitions (RM). The PG progressed the aerobic and resistance training from 40–49% to 60–69% (HRres) and from 2 × 12–14 to 2 × 8–10 RM, respectively, along intervention period. The evaluated indicators of insulin resistance included fasting glucose, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) collected pre and post intervention. The analyses to verify the exercise training effect were performed using generalized estimating equations. Results After 16 weeks of training, per protocol analysis (n = 39) showed significant reductions in HOMA-IR only in the training groups (NG: ∆=-1.6, PG: ∆=-0.6; p = 0.094). Intention-to-treat analysis demonstrated significant reductions in fasting insulin levels (NG: ∆=-1.4, PG: ∆=-1.0; p = 0.004) and HOMA-IR (NG: ∆=-5.5, PG: ∆=-3.8; p = 0.002). Conclusion Periodized and non-periodized combined exercise training reduces similarly insulin resistance markers in adults with obesity.