Effects of non-ionic iodinated contrast media on patient heart rate and pressures during intra-cardiac or intra-arterial injection

Schmid, Isabelle; Didier, Dominique; Pfammatter, Thomas; Garachemani, Ali; Fleisch, Martin; Kirchin, Miles A.; Meier, Bernhard

doi:10.1016/j.ijcard.2006.12.011

Cited by 21 publications

(8 citation statements)

References 28 publications

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“…We used one type of compound and iodine concentration (iomeprol 400 mg I/ml) for all patients in our series. This compound is characterised by high iodine concentration/osmolality and there are claims that a higher osmolality may determine an increase in heart rate; however, the reports are not univocal on this finding [28][29][30]. We do not know if this effect can be related to the contrast material itself and/or to the warm sensation determined by contrast material.…”

Section: Discussionmentioning

confidence: 89%

“In-house” pharmacological management for computed tomography coronary angiography: heart rate reduction, timing and safety of different drugs used during patient preparation

et al. 2009

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We retrospectively evaluated the effect, timing and safety of different pharmacological strategies during 64-slice CT coronary angiography (CT-CA). From the institutional database of CT-CAwe enrolled 560 consecutive patients with suspected coronary artery disease. The type of drug preparation (group 1 = no treatment; group 2 = oral metoprolol; group 3 = other; group 4 = intravenous (IV) atenolol; group 5 = IV atenolol + nitrates; NR = non-responders), timing, and adverse effects were recorded. Heart rate (HR) during different preparation phases was recorded. Four adverse effects were recorded, none of which was attributable to pharmacological treatment. In all groups, except group 1, the HR on arrival was significantly reduced by the pharmacological treatment (p<0.01). Group 4 showed the best (-16±8 bpm) HR reduction. There was no significant effect on HR due to nitrates (p = 0.49), while a slight increase due to contrast material was noted (p<0.05). Average time required for preparation was 44±25min. Groups 4 and 5 showed the most effective timing (8±9 min and 8±8 min, respectively; p<0.01). Pharmacological preparation in patients undergoing CT-CA is safe and effective. Best results in terms of HR reduction and fast preparation are obtained with IV administration of beta-blockers.

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Section: Discussionmentioning

confidence: 89%

“In-house” pharmacological management for computed tomography coronary angiography: heart rate reduction, timing and safety of different drugs used during patient preparation

et al. 2009

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“…13,14, Overall, 7166 patients; 3672 patients received iodixanol and 3494 patients received LOCM (Tables 1 and 2). Although several definitions of CIN were used, as listed in Table 1, most studies measured the postprocedure creatinine value at 1, 2, or 3 days (nϭ24).…”

Section: Resultsmentioning

confidence: 99%

“…11,12 Since the publication of this study, several new randomized trials have been performed to better elucidate the role of iodixanol in radiographic procedures. [13][14][15] The goal of our meta-analysis was to assess the efficacy of iodixanol compared with LOCM for prevention of CIN. We hypothesized that in a large analysis without exclusion of trials based on procedure type or population studied, the incidence of CIN would be reduced by iodixanol when compared with LOCM.…”

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confidence: 99%

Iodixanol Versus Low-Osmolar Contrast Media for Prevention of Contrast Induced Nephropathy

From

Badarin

McDonald

et al. 2010

Circ: Cardiovascular Interventions

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Background-Contrast-induced nephropathy (CIN) is associated with significant morbidity and mortality. The objective of our meta-analysis was to assess the efficacy of iodixanol compared with low-osmolar contrast media (LOCM) for prevention of CIN. Methods and Results-We searched MEDLINE, the Cochrane Central Register of Controlled Trials, and internet sources of cardiology trial results for individual and relevant reviews of randomized, controlled trials, for the terms contrast media, contrast nephropathy, renal failure, iodixanol, Visipaque, and low-osmolar contrast media. All studies reported an incidence rate of CIN for each study group; there was no restriction on the definition of CIN. There were no restrictions on journal type or patient population. Overall, 36 trials were identified for analysis of aggregated summary data on 7166 patients; 3672 patients received iodixanol and 3494 patients received LOCM. Overall, iodixanol showed no statistically significant reduction in CIN incidence below that observed with heterogeneous comparator agents (Pϭ0.11). Analysis of patient subgroups revealed that there was a significant benefit of iodixanol when compared with iohexol alone (odds ratio, 0.25; 95% confidence interval, 0.11 to 0.55; PϽ0.001) but not when compared with LOCM other than iohexol or with other ionic dimers or among patients receiving intra-arterial contrast injections or among patients undergoing coronary angiography with or without percutaneous intervention. Conclusions-Analysis

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“…A total of 13 investigations were reported in the 2 prospective cross-sectional studies [2,3] and 11 randomized controlled trials (RCTs) [1,[7][8][9][12][13][14][15][16][17][18]. The study quality was generally excellent for the RCTs included, overall, two trials had a Jadad score of 5, five scored 4, two scored 3, and the remaining two scored 2.…”

Section: Study Characteristicsmentioning

confidence: 99%

A meta-analysis of the risk of total cardiovascular events of isosmolar iodixanol compared with low-osmolar contrast media

Zhang

Wang

et al. 2014

Journal of Cardiology

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Effects of non-ionic iodinated contrast media on patient heart rate and pressures during intra-cardiac or intra-arterial injection

Cited by 21 publications

References 28 publications

“In-house” pharmacological management for computed tomography coronary angiography: heart rate reduction, timing and safety of different drugs used during patient preparation

“In-house” pharmacological management for computed tomography coronary angiography: heart rate reduction, timing and safety of different drugs used during patient preparation

Iodixanol Versus Low-Osmolar Contrast Media for Prevention of Contrast Induced Nephropathy

A meta-analysis of the risk of total cardiovascular events of isosmolar iodixanol compared with low-osmolar contrast media

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