Effects of Noise Exposure and Aging on Behavioral Tone Detection in Quiet and Noise by Mice

Burke, Kali; Screven, Laurel A.; Kobrina, Anastasiya; Charlton, Payton E; Schrode, Katrina M.; Villavisanis, Dillan F.; Dent, Micheal L.; Lauer, Amanda M.

doi:10.1523/eneuro.0391-21.2022

Cited by 11 publications

(14 citation statements)

References 57 publications

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“…Compensatory plasticity in the A1 after peripheral damage supports the recovery of the perceptual sound-detection threshold but does not support sound processing encoded by precise spike timing, such as modulated noise or speech and restricts hearing in a noisy environment 10,11,15,84,85 . Interestingly, A1 SOM neurons, which are critically important for sound processing encoded by precise spike timing of neuronal firing 43,44,86,87 , showed reduced sound-evoked activity after NIHL (Fig.…”

Section: Discussionmentioning

confidence: 92%

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Cell-type-specific roles of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage

Kumar

Handy

Kouvaros

et al. 2022

Preprint

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Peripheral sensory organ damage leads to compensatory cortical plasticity that supports a remarkable recovery of perceptual capabilities. A major knowledge gap is the lack of precise mechanisms that explain how this plasticity is implemented and distributed over a diverse collection of excitatory and inhibitory cortical neurons. Here, we explored these mechanisms in mouse A1. After peripheral damage, we found recovered sound-evoked activity of excitatory principal neurons (PNs) and parvalbumin (PVs) interneurons (INs), reduced activity in somatostatin-INs (SOMs), and recovered activity in vasoactive intestinal peptide-INs (VIPs). Given the sequentially organized cortical network where VIPs inhibit INs, SOMs inhibit PVs and PNs, and PVs inhibit PNs, our results suggest that PVs contribute to PN stability, SOMs allow for increased PN and PV activity, and VIPs enable the PN and PV recovery by inhibiting SOMs. These results highlight a strategic, cooperative, and cell-type-specific plasticity program that restores cortical sound processing after peripheral damage.

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Section: Discussionmentioning

confidence: 92%

Section: Maladaptive Aspects Of Cortical Plasticitymentioning

confidence: 93%

Cell-type-specific roles of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage

Kumar

Handy

Kouvaros

et al. 2022

Preprint

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“…Operant assays for behavioral reporting of conscious sound awareness represent the gold standard for hearing assessments. However, training animals to perform operant tasks can take weeks, which makes measurements of complex sound processing difficult in most animal models and prohibitive for models of disordered sound perception that also have generalized motor, vestibular or cognitive impairments [45][46][47][48]. Alternatively, physiological proxies for hearing, such as the auditory brainstem response (ABR) can be measured in minutes but, as gross electrical potentials generated in the brainstem of anesthetized animals, these measures are not interchangeable with hearing assessments.…”

Section: Facial Videography Is a Sensitive Readout Of Behavioral Regi...mentioning

confidence: 99%

Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities

Clayton,

Stecyk,

Guo

et al. 2023

Preprint

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SUMMARYSound elicits rapid movements of muscles in the face, ears, and eyes that protect the body from injury and trigger brain-wide internal state changes. Here, we performed quantitative facial videography from mice resting atop a piezoelectric force plate and observed that broadband sounds elicit rapid, small, and highly stereotyped movements of a facial region near the vibrissae array. Facial motion energy (FME) analysis revealed sensitivity to far lower sound levels than the acoustic startle reflex and greater reliability across trials and mice than sound-evoked pupil dilations or movement of other facial and body regions. FME tracked the low-frequency envelope of sounds and could even decode speech phonemes in varying levels of background noise with high accuracy. FME growth slopes were disproportionately steep in mice with autism risk gene mutations and noise-induced sensorineural hearing loss, providing an objective behavioral measure of sensory hyper-responsivity. Increased FME after noise-induced cochlear injury was closely associated with the emergence of excess gain in later waves of the auditory brainstem response, suggesting a midbrain contribution. Deep layer auditory cortex units were entrained to spontaneous facial movements but optogenetic suppression of cortical activity facilitated – not suppressed – sound-evoked FME, suggesting the auditory cortex is a modulator rather than a mediator of sound-evoked facial movements. These findings highlight a simple involuntary behavior that is more sensitive and integrative than other auditory reflex pathways and captures higher-order changes in sound processing from mice with inherited and acquired hearing disorders.

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“…In everyday life, speech stimuli are often encoded in the presence of other auditory distractors (i.e., background noise) that mask or reduce the saliency of the stimuli of interest. Previously, animal studies revealed that prolonged exposure to noise can result in tonotopic map reorganization in auditory areas of the brain‚ which results in poor auditory perception outcomes (Burke et al 2022; Noreña & Eggermont 2005). However, enriched auditory environments (enhanced relevant auditory signals) might prevent such adverse effects (Noreña & Eggermont 2005).…”

Section: Introductionmentioning

confidence: 99%

Plasticity Changes in Central Auditory Systems of School-Age Children Following a Brief Training With a Remote Microphone System

et al. 2023

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Objectives:The objective of this study was to investigate whether a brief speech-in-noise training with a remote microphone (RM) system (favorable listening condition) would contribute to enhanced post-training plasticity changes in the auditory system of school-age children. Design:Before training, event-related potentials (ERPs) were recorded from 49 typically developing children, who actively identified two syllables in quiet and in noise (+5 dB signal-to-noise ratio [SNR]). During training, children completed the same syllable identification task as in the pre-training noise condition, but received feedback on their performance. Following random assignment, half of the sample used an RM system during training (experimental group), while the other half did not (control group). That is, during training‚ children in the experimental group listened to a more favorable speech signal (+15 dB SNR) than children from the control group (+5 dB SNR). ERPs were collected after training at +5 dB SNR to evaluate the effects of training with and without the RM system. Electrical neuroimaging analyses quantified the effects of training in each group on ERP global field power (GFP) and topography, indexing response strength and network changes, respectively. Behavioral speech-perception-in-noise skills of children were also evaluated and compared before and after training. We hypothesized that training with the RM system (experimental group) would lead to greater enhancement of GFP and greater topographical changes post-training than training without the RM system (control group). We also expected greater behavioral improvement on the speech-perception-in-noise task when training with than without the RM system.Results: GFP was enhanced after training only in the experimental group. These effects were observed on early time-windows corresponding to traditional P1-N1 (100 to 200 msec) and P2-N2 (200 to 400 msec) ERP components. No training effects were observed on response topography. Finally, both groups increased their speech-perception-in-noise skills post-training.Conclusions: Enhanced GFP after training with the RM system indicates plasticity changes in the neural representation of sound resulting from listening to an enriched auditory signal. Further investigation of longer training or auditory experiences with favorable listening conditions is needed to determine if that results in long-term speech-perception-innoise benefits.

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Effects of Noise Exposure and Aging on Behavioral Tone Detection in Quiet and Noise by Mice

Abstract: Visual Abstract

Cited by 11 publications

References 57 publications

Cell-type-specific roles of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage

Cell-type-specific roles of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage

Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities

Plasticity Changes in Central Auditory Systems of School-Age Children Following a Brief Training With a Remote Microphone System

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