Effects of nitroglycerine spray and lignocaine spray on the hemodynamic responses to laryngoscopy and endotracheal intubation: A comparative study

Datla, Sasidhar; Samuel, Mary; Teja, Vishnu; ., Fathima; Kumari, Anshu

doi:10.4103/ijhas.ijhas_19_20

Int J Health Allied Sci

2020

DOI: 10.4103/ijhas.ijhas_19_20

|View full text |Cite

Effects of nitroglycerine spray and lignocaine spray on the hemodynamic responses to laryngoscopy and endotracheal intubation: A comparative study

Sasidhar Datla

Mary Samuel

Vishnu Teja

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Efficacy of Transmucosal Nitroglycerin Spray versus Intravenous Lignocaine for the Attenuation of Hemodynamic Responses to Intubation

Rajan,

Raveendran,

Bhuyan

et al. 2024

Journal of Indian College of Anaesthesiologists

View full text Add to dashboard Cite

Background and Aims: Intravenous (IV) lignocaine and sublingual nitroglycerin (NTG) obtund intubation responses. We aimed to compare heart rate (HR) and mean arterial pressure (MAP) changes following direct laryngoscopy and intubation after transmucosal NTG spray versus IV lignocaine. Methods: Sixty participants were randomized equally into two groups. Group A patients received IV lignocaine 1.5 mg/kg, 90 s before intubation. Oropharynx of Group B patients was sprayed with 800 μg of NTG oral spray just before induction. General anesthesia regimen for induction, intubation, and maintenance was similar for all patients. HR and MAP at predefined time points and incidence of intraoperative hypotension were noted. Results: Intergroup analysis showed comparable HR in both the groups till 10 min. There was no significant difference in baseline MAP in both the groups. MAP was significantly higher in Group A till 10 min after intubation. Intragroup analysis of HR in Group A showed no significant difference from baseline after induction, 1, 3, and 5 min after intubation. HR at different time points was comparable with baseline during the study period in Group B. A significant fall in MAP from baseline was noted in Group A except at 1 min after intubation. In Group B, a significant fall in MAP from baseline was noted till 15 min after intubation. The incidence of intraoperative hypotension was significantly higher in Group B compared with Group A (40% vs. 3.3%). Conclusion: Both IV lignocaine and transmucosal NTG spray attenuated hemodynamic responses to intubation. However, considering a significantly lesser fall in MAP, IV lignocaine 1.5 mg/kg can be considered superior to 800 μg of transmucosal NTG spray for safely attenuating hemodynamic response to intubation.

show abstract

Efficacy of Transmucosal Nitroglycerin Spray versus Intravenous Lignocaine for the Attenuation of Hemodynamic Responses to Intubation

Rajan,

Raveendran,

Bhuyan

et al. 2024

Journal of Indian College of Anaesthesiologists

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effects of nitroglycerine spray and lignocaine spray on the hemodynamic responses to laryngoscopy and endotracheal intubation: A comparative study

Cited by 1 publication

References 16 publications

Efficacy of Transmucosal Nitroglycerin Spray versus Intravenous Lignocaine for the Attenuation of Hemodynamic Responses to Intubation

Efficacy of Transmucosal Nitroglycerin Spray versus Intravenous Lignocaine for the Attenuation of Hemodynamic Responses to Intubation

Contact Info

Product

Resources

About