Abstract:Clostridium difficile (C.diff) is a leading cause of infectious colitis in humans. C.diff toxins disrupt the intestinal epithelial barrier and induce the release of proinflammatory mediators. The hypoxia‐inducible factor‐1 (HIF‐1α) is a stress‐induced transcription factor that mediates mucosal and barrier protective genes. Nitric oxide (NO) and the factor‐inhibiting HIF‐1α (FIH‐1) modulate HIF‐1α expression and signaling, respectively. We hypothesize that NO produced during C.diff toxin‐induced intestinal inju… Show more
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