Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli- and Salmonella Typhimurium-induced secretion in the porcine small intestine

Grøndahl, Marie Louise; Unmack, Martin Andreas; Ragnarsdóttir, Helga Berglind; Hansen, Mark Berner; Olsen, John Elmerdahl; Skadhauge, Erik

doi:10.1016/j.cbpb.2005.07.001

Cited by 7 publications

(6 citation statements)

References 48 publications

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“…The role of SPI-1 in the intestinal phase of infection has been shown earlier for Salmonella choleraesuis in pigs [24] and for Salmonella Typhimurium and Salmonella Dublin in calves [25,26]. Recently, Grondahl and coworkers [27] found that an invH mutant strain, although not impaired for invasion, was attenuated for the induction of an inflammatory response in pigs.…”

Section: Discussionmentioning

confidence: 96%

Salmonella Typhimurium SPI-1 genes promote intestinal but not tonsillar colonization in pigs

Boyen

Pasmans

Immerseel

et al. 2006

Microbes and Infection

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Section: Discussionmentioning

confidence: 96%

Salmonella Typhimurium SPI-1 genes promote intestinal but not tonsillar colonization in pigs

Boyen

Pasmans

Immerseel

et al. 2006

Microbes and Infection

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“…62 As a consequence, serotonin receptors on enterocytes and on intrinsic and extrinsic, primary nerve endings are activated in a paracrine fashion. 63,64 Activation of intrinsic afferents results in neural reflexes that enhance the release of chloride ions and water into the intestinal lumen. 65 This increase in luminal fluid in turn stimulates bowel motility, which ultimately helps remove intestinal contents, including pathogenic bacteria.…”

Section: Enterochromaffin Cells As Signal Transducersmentioning

confidence: 99%

Principles and clinical implications of the brain–gut–enteric microbiota axis

Rhee¹,

Pothoulakis²,

Mayer

2009

Nat Rev Gastroenterol Hepatol

1,056

789

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While bidirectional brain–gut interactions are well known mechanisms for the regulation of gut function in both healthy and diseased states, a role of the enteric flora—including both commensal and pathogenic organisms—in these interactions has only been recognized in the past few years. The brain can influence commensal organisms (enteric microbiota) indirectly, via changes in gastrointestinal motility and secretion, and intestinal permeability, or directly, via signaling molecules released into the gut lumen from cells in the lamina propria (enterochromaffin cells, neurons, immune cells). Communication from enteric microbiota to the host can occur via multiple mechanisms, including epithelial-cell, receptor-mediated signaling and, when intestinal permeability is increased, through direct stimulation of host cells in the lamina propria. Enterochromaffin cells are important bidirectional transducers that regulate communication between the gut lumen and the nervous system. Vagal, afferent innervation of enterochromaffin cells provides a direct pathway for enterochromaffin-cell signaling to neuronal circuits, which may have an important role in pain and immune-response modulation, control of background emotions and other homeostatic functions. Disruption of the bidirectional interactions between the enteric microbiota and the nervous system may be involved in the pathophysiology of acute and chronic gastrointestinal disease states, including functional and inflammatory bowel disorders.

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“…However, species and segmental differences also exist for these mechanisms (Grondahl et al 1996, Hardcastle & Hardcastle 1997. Nitric oxide is involved in 5-HT-induced secretion in rat and pig, but not in murine intestines (Kadowaki et al 1996, Beubler & Schirgi-Degen 1997, Stoner et al 2000, Tuo & Isenberg 2003, Grondahl et al 2005). Nitric oxide is involved in 5-HT-induced secretion in rat and pig, but not in murine intestines (Kadowaki et al 1996, Beubler & Schirgi-Degen 1997, Stoner et al 2000, Tuo & Isenberg 2003, Grondahl et al 2005).…”

Section: Serotonin Receptors In Intestinal Secretionmentioning

confidence: 99%

“…This can be exemplified by the involvement of nitric oxide in 5-HT-induced intestinal secretions, which has been investigated based on the effects of the nitric oxide synthase inhibitor, N x -nitro-l-arginine methyl ester. Nitric oxide is involved in 5-HT-induced secretion in rat and pig, but not in murine intestines (Kadowaki et al 1996, Beubler & Schirgi-Degen 1997, Stoner et al 2000, Tuo & Isenberg 2003, Grondahl et al 2005).…”

Section: Serotonin Receptors In Intestinal Secretionmentioning

confidence: 99%

The role of serotonin in intestinal luminal sensing and secretion

2008

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This mini-review addresses the role of the neuroendocrine substance serotonin (5-hydroxytryptamine, 5-HT) in intestinal luminal sensing and secretion. Intestinal sensory neurones are activated by several mechanisms, in particular following stimulation of 'specialized' cells in the mucosa. These specialized cells are the enteroendocrine cells, which contain a wide variety of neuroendocrine transmitters. One of these enteroendocrine cells is the enterochromaffin (EC) cell, which is present throughout the intestines and contains large amounts of serotonin, predominantly in the duodenum in humans. The EC cells act as mucosal sensory transducers and secrete serotonin in response to various physiological and pathological luminal stimuli. Following release, serotonin participates in several mucosal protecting processes, one being secretion. Serotonin stimulates active ion, mucus and fluid secretion. Epithelial 5-HT(2) receptors and neuronal 5-HT(1P), 5-HT(3) and 5-HT(4) receptors mediate the secretory effect of serotonin. A transmembrane serotonin transporter terminates epithelial serotonergic signalling. The transient receptor potential ion channel family is important for processing intestinal luminal sensory signalling. Accumulating evidence suggests a significant interaction between serotonin and one of the transient receptor potential ion channels, the capsaicin-sensitive transient receptor potential vanilloid type 1. Accordingly, EC cells, serotonergic receptors and transporter(s), and transient receptor potential vanilloid type-1 ion channels are all explored as pharmacological targets for treatment of some intestinal functional disorders.

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Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli- and Salmonella Typhimurium-induced secretion in the porcine small intestine

Cited by 7 publications

References 48 publications

Salmonella Typhimurium SPI-1 genes promote intestinal but not tonsillar colonization in pigs

Salmonella Typhimurium SPI-1 genes promote intestinal but not tonsillar colonization in pigs

Principles and clinical implications of the brain–gut–enteric microbiota axis

The role of serotonin in intestinal luminal sensing and secretion

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