Effects of nitric oxide in orthodontic tooth movement in rats

Akın, Erol; Gurton, Arif Umit; Ölmez, Hüseyin

doi:10.1016/j.ajodo.2003.08.032

Cited by 48 publications

(39 citation statements)

References 38 publications

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“…Another interesting fact is that the absence of this cytokine impairs PGE2 and NO production (Hurwitz et al, 1997;Ralston & Grabowski, 1996), which favors anabolic activity in the bone mechanotransduction pathway mentioned in the previous section. Nitric oxide (NO) increases root and bone resorption in orthodontics (Akin, Gurton & Olmez, 2004;Leitao et al, 2005;Leitao et al, 2004), an effect opposite to that in orthopedic reactions. Currently, there is no proven explanation for these contradictions.…”

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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“…[1][2][3] Because the short cycle in female rats causes hormonal variations, our study was carried out with male rats. 28,29 In previous studies, orthodontic force was exerted by closed coil springs between the molars and incisors or elastics between the first and second molars of the rat.…”

Section: Discussionmentioning

confidence: 99%

“…The principal cytokines that have been shown to affect skeletal tissues include factors previously described as monokines or lymphokines, colony-stimulating factors, prostaglandins, and differentiation factors. [1][2][3] The T helper 1 cytokine interferon-gamma (IFN-␥) is one of them.…”

Section: Introductionmentioning

confidence: 99%

Effects of Interferon-Gamma on Bone Remodeling during Experimental Tooth Movement

Mermut

Bengi

Akın

et al. 2007

The Angle Orthodontist

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“…Alveolar bone and the periodontal ligament (PDL) are compressed on one side, while on the opposite side, the PDL is stretched. Mechanical stress on the stretched PDL induces alveolar bone modeling (surface apposition of bone), while mechanical compression gives rise to bone remodeling (the turnover of bone in small pockets (1,2). Orthodontic tooth movement is an inflammation-like process, in which inflammatory mediators play an important role.…”

Section: Introductionmentioning

confidence: 99%

Effect of psychological stress on orthodontic tooth movement in rats

Mirzakouchaki

Firoozi²,

Shahrbaf³

2011

Med Oral

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Introduction: The purpose of this study was to investigate the effect of psychological stress on orthodontic tooth movement in Wistar rats. Materials and methods: Forty-eight female ten-week old Wistar rats with an average weight of 188 ±12 gr were selected and randomly divided into two experimental and control groups. The experimental group received crowded environment-induced and cat odour stresses 4 weeks before spring insertion. On the 29th day in both groups, maxillary incisors were moved by the insertion of springs and exactly after 7 days, 9 rats from each group and after 14 days the remaining rats were sacrificed. Then the mesioincisal distance between maxillary incisors was measured. Afterwards, histological sections were prepared to count osteoclasts under a light microscope. The data on the extent of orthodontic tooth movement and the number of osteoclasts were analyzed by independent sample t-test. Results: The results indicated that on the 7th day after spring placement the orthodontic tooth movement was significantly higher in the control group compared to the experimental group (p<0.05). The number of osteoclasts at a significance level of α=0.1 in the control group was higher compared to the experimental group. On the 14th day after spring placement, the orthodontic tooth movement in the control group was significantly higher compared to the experimental group (p<0.05). However, there were no significant differences in the number of osteoclasts between the two groups. The rats experienced weight loss in the experimental group (p<0.05). Conclusions: Psychological stress led to a decrease in orthodontic tooth movement and in the number of osteoclasts around the root in the movement direction in rats, but a decrease in osteoclast counts was not parallel with time and demonstrated a nonlinear pattern. In addition, psychological stress led to weight loss in rats.

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Effects of nitric oxide in orthodontic tooth movement in rats

Cited by 48 publications

References 38 publications

Orthodontic mechanotransduction and the role of the P2X7 receptor

Orthodontic mechanotransduction and the role of the P2X7 receptor

Effects of Interferon-Gamma on Bone Remodeling during Experimental Tooth Movement

Effect of psychological stress on orthodontic tooth movement in rats

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