Effects Of Nimodipinee On Cerebral Hemodynamic And Prognosis Of Diffuse Axonal Injury Patients With Repeated Measurements Design

Abstract

In medical and behavioral researches experimental units, are often the people who are in different social status, physical and other tendency So their responses will be different. In these situations they are required to control the changes in the result of this sources that are potentially variable otherwise the source of variability can increase mean square error significantly and make impossible revealing the real difference between treatments. Appropriate model for such research projects are repeated measurements. This study is a prospective study that accesses the effects of Nimodipinee on Hemodynamic changes of cerebral vessels and the short time prognosis in DAI patients. The study was done in Trauma word of Imam Reza hospital of Tabriz Iran. Forty DAI patients were randomized in two equals groups the case group underwent treatment with Nimodipine drug (every 4 hours after admission) Control groups did not received this treatment. Hemodynamic changes in these patients were measured using transcranial Doppler machine on the first third and tenth days of admission. Using a repeated measurements design fitting model